Immunology- Immunodeficiencies

Question 1

Typical pathogens with defective opsonization

Answer 1

Encapsulated bacteria (e.g. step pneumoniae)

Question 2

causes of poor opsonization

Answer 2

Decreased immunoglobulin production

Complement dysfunction

Question 3

Chronic granulomatous disease (CGD)

Answer 3

X-Recessive mutation of NADPH oxidase.
Impaired respiratory burst and decreased superoxide anions inhibit phagocytic degradation.

Infections with catalase positive organisms.

Question 4

Presentation of CGD

Answer 4

Recurrent Lung infections 
Abscesses 
Perirectal infection 
Diffuse Granulomas 
Boys

Question 5

Catalase positive organisms

Answer 5

S. Aureus 
B. Cepacia (pseudomonas)
Serratia marcescens
Nocardia
Aspergillus

Question 6

CVID

Answer 6

Low immunoglobulin levels typically resets in adolescence or adulthood

Question 7

X-links agammaglobulinemia key characteristic

Answer 7

No tonsillar or adenoidal tissue due to lack of mature B cells

Question 8

pattern of inheritance of Kartagener syndrome

Answer 8

AR

Question 9

Mechanism of immune deficiency in asplenia

Answer 9

Encapsulated organisms have an exterior that conceals antigenic epitopes and resists phagocytosis. These organism depend on splenic macrophages for antibody mediated phagocytosis and antibody mediated complement activation