NEURO 230 Pain Flashcards
What is pain?
Unpleasant sensory and emotional experience associated with potential or actual tissue damage
What is nociception?
Sensory process providing signals that provide pain
What is congenital insensitivity pain syndrome?
mutation in Na+ channels meaning no pain sensation therefore reducing life expectancy
What is chronic pain?
Pain that persists beyond normal healing time 3-6 months
What is hyperalgaesia?
increased pain response to a noxious stimuli
What is allodynia?
Pain response to a non-noxious stimuli
What is parasthesia?
Pain response in absence of any stimulus
What are nociceptors and give some examples
Free nerve endings with specific receptors on membrane
e.g Thermal: TRPV1 detects temperature and spicy food (capsaicin)
Chemical - inflammation
Mechanical - excessive stretch
What different nociceptive fibres are there?
A-delta, C fibres, A beta fibres and Aalpha fibres
Describe A-delta fibres?
Fast pain fibres - they are unimodal, myeliinated fibres so can only detect one type of pain that is not necessarily distinguishable
Describe C fibres
Slow pain fibres that are unmyelinated but polymodal and can provide further information about the pain
Describe A-beta fibres
detect pressure and tactile sensation and have a slow response - enter spinal cord through same pathway as A-delta and can inhibit them by activating inhibitory interneurones
e.g. rubbing an injury lessens pain
What are A-alpha fibres
Myotatic reflex ! fast fibres detecting stretch in the GTO/muscle spindle
What is the 1st order neurone in pain pathway?
Nociceptors
What is the 2nd order neurone in the pain pathway?
Spinothalamic tract/ Ascending pathways