ENDO 111 Obesity Flashcards
What BMI defines obesity?
30kg/m^2
What BMI defines morbid obesity?
40kg/m^2
What is metabolic syndrome?
Central obesity measured by waist circumference with 2 or more of:
increased [blood TG]
decreased [blood HDL] / increased [LDL]
Increased BP and blood glucose
What does Leptin do?
triggers production of active peptide in the hypothalamus that controls hunger and metabolism - burn calories
What does Ghrelin do?
stimulates appetite
What are the major fuels n the body and where do they arise from?
Glucose and Lactate from carbohydrate/ carb metabolism
FA’s and ketone bodies from fat/FA metabolism
Amino acids from protein
What tissues use fatty acids as a fuel?
Liver, Kidney cortex, cardiac muscle and skeletal muscle
What tissues depend on glucose as a fuel?
RBC, lymphocytes, brain and skeletal muscle
What tissues use ketone bodies?
Cardiac muscles, kidney cortex, skeletal muscle and brain in starvation
What factors raise a persons basal metabolic rate?
hyperthyroidism, cold exposure, regular exercise, disease and fever
What factors lower a persons basal metabolic rate?
hypothyroidism, dieting/starvation, being idle, hypothermia
What does a lesion of the ventromedial hypothalamus produce?
Hyperphagia
What does a lesion in the lateral hypothalamus result in?
decrease in body weight
How does the hypothalamus sense your weight?
Leptin ( an adipostat) produce by fat - more fat = more leptin
Where does leptin act primarily?
In the arcuate nucleus of the hypothalamus
