Nervous System (Lecture) Flashcards
Define function of the nervous system
- Respond to internal and external stimuli
- Coordination
- Higher functioning (learning, behavior, memory, etc)
Central Nervous system components
Brain and spinal cord
Components of peripheral nervous system
Nerves and receptors
Neuron function
- Receive signal
2. Transmit signal
3. Send signal (affect another cell)
Myelin Sheath
- layers of plasma membrane wrapped around axon
- glial cell
Describe saltatory conduction
Action potential jumps between nodes of ranvier
What are glial cells (glia) and what are the different types?
Supporting cells for neurons
- Oligodendrocytes
- Schwann cells
- Astrocytes
- Microglia
Describe oligodendrocytes
- make myelin sheath in the CNS
- Myelinates multiple regions of multiple neurons
What is multiple sclerosis?
- Autoimmune disease that damages oligodendrocytes which results in the loss of myelin sheath of neurons
- degenerative disease
Describe Schwann cells
- make myelin sheath in the PNS
- myelinates one region of one neuron
What is Guillain-Barré syndrome?
- autoimmune disease that attacks Schwann cells which disrupts myelin sheath production of peripheral nerves
- reversible, non-degenerative disease
Define astrocytes
Acts as blood-brain barrier (filters anything going from the blood to neurons)
Define Microglia
Macrophages in brain and spinal cord
Define gray matter (CNS)
- cell bodies, dendrites, etc.
- information processing
White matter (CNS)
- Myelinated axons
- signal transmission
Nerves
collection of axons (PNS)
Tract
Collection of axons (CNS)
Ganglion (Ganglia)
Cell bodies (PNS)
Nucleus
Cell bodies (CNS)
Nerve Plexus
Collection of Nerves
Sensory Neurons
- Afferent neurons
- Carry info to CNS
Interneurons
- association neurons
- neurons in CNS
Motor Neurons
- Efferent Neurons
- leave CNS
Describe the Brain
- Localization of function -> coordinated and integrated function
- contralateral function
- R & L hemispheres
- Connected by Corpus
callosum
- Divided by longitudinal
fissure
- R & L hemispheres
Describe the cerebrum
- higher level functioning
- cerebral cortex (gray matter)
- gyrus sulcus - folds and grooves in brain
Significant gyri of frontal lobe
- separated by central sulcus
- Gyrus (I)
- Precentral (primary motor cortex)
- postcentral (primary somato-sensory cortex)
What makes up the diencephalon?
- Thalamus
- Hypothalamus
- Epithalamus
Describe the thalamus
- Relay center (sensory information, except smell)
- Many nuclei
Describe the hypothalamus
- controls endocrine system through the pituitary gland
- Controls autonomic nervous system
Describe the epithalamus
- pineal gland (circadian rhythm regulation through release of melatonin)
Primary somatosensory cortex
- post central gyrus
- somatosensory association area (parietal lobe)
Primary visual cortex
primary visual association area
Primary auditory cortex
primary association area
Broca’s area function
makes speech
Wernicke’s area function
comprehend speech
Primary motor cortex
primary motor association area
What structures make up the brain stem?
- midbrain
- pons
- medulla oblongata
Midbrain
- visual and auditory reflexes
- corpura quadrigemina
- superior colliculi (visual)
- Inferior colliculi (auditory)
- corpura quadrigemina
Pons
nuclei for cranial nerves
Medulla oblongata
- controls muscles of breathing
- reticular activating system (how awake you are. acted on by melatonin)
- Ex: TBI induced encephalopathy pushes on medulla oblongata leading to coma
Cerebellum
- coordinates movement with basal ganglia through proprioceptors found in joints, tendons, and muscles
- the basal ganglia ensures smooth movement
What is affected by the limbic system?
- smell
- emotions
- behavior
- planning
- memory
- control physiological function
They are all affected by pheromones
Smell is received by the olfactory bulb
Frontal lobe
- prefrontal lobe -> higher level function, behavior emotions
Hippocampus
Converts short term memory to long term memory
What is dementia?
- Brain degeneration
- thinking, memory, and control of body all degrade
- muscular problems
- personality changes
- fatal
Alzheimers
- type of dementia where beta-amyloid plaques are present
Lewy body dementia
- type of dementia where lewy bodies are present (plaques of lewy protein)
Vascular dementia
TIA
Dementia Secondary to Trauma
- most common in athletes
- concussions (significant damage to brain causing syncope)
- CTE
Spinal cord
Comes off medulla oblongata, exits foramen magnum to L1 and L2 vertebrae
two types of Spinal Tracts
Ascending pathway and descending pathway
Ascending pathway; spinal tract
- Dorsal column pathway
- somatic senses
- sends signal to thalamus to postcentral gyrus - Spinocerebellar tract
- from proprioceptors
- send signal to cerebellum
Descending Tract; spinal tract
- corticospinal tract
- from pre-central gyrus - vestibulospinal tract
- from basal ganglia
Falx cerebri
large, crescent-shaped fold of dura mater that descends vertically into the longitudinal fissure between the cerebral hemispheres
Superior Sagittal Sinus
All sinuses drain into internal jugular
Arachnoid Villus
Drain CSF into SSS
What is cerebrospinal fluid
- Allows brain to float (decrease weight of brain and maintain shape)
- Cushions brain
- Drains fluid from CNS (no lymphatic system)
Describe CSF circulation
- Made in choroid plexus
- Fills and travels through ventricles
- central canal of spinal cord
- subarachnoid space
- arachnoid villi
- Supra Sagittal Sinus
Describe travel of CSF through ventricles
2nd lateral ventricles -> 3rd lateral ventricles -> cerebral aqueduct -> 4th ventricle -> central canal of spinal cord
Hydrocephalus
- blockage in cerebral aqueduct (congenital or tumor)
- massive brain damage
- fatality risk lower in Peds because of incomplete skull formation
Tx: - remove blockage
- shunt placed to remove excess fluid
Meningitis
- meninges inflammation; can result in encephalitis
Dx: Lumbar puncture
Initial Sx: headache w/ stiff neck
Tx: medication
Subdural Hemorrhage
- from trauma
- ICP increases pressure on brain
Tx: Drain blood
Epidural Injection
- Epidural space lower than spinal cord
- local anesthetic
Diabetic Peripheral Neuropathy
Elevated BGL
Shingles
- Dormant in dorsal root ganglion
Dx: striated rash
Compare Sympathetic and Parasympathetic functions
Sympathetic
- fight/flight
- increased HR & RR
- slow digestion
dilate pupils
Parasympathetic
- rest and digest
- decreased HR and RR
- speed digestion
- constrict pupils
Referred Pain
Pain felt from organs felt somewhere else due to innervation
Trigeminal Neuralgia
Inflammation of trigeminal nerve (CN V) causing it to get pinched in foramen of the skull
Bells Palsy
Inflammation of Facial nerves (CN VII) causing loss of function in facial movement
Dermatomes
Region of skin innervated by single spinal nerve
CN I
Olfactory Nerve
Sensory nerve for smell
CN II
Optic Nerve
Sensory nerve for vision (from retina)
CN III
Oculomotor nerve
Motor nerve to 4 of 6 extrinsic eye muscles
Parasympathetic nerve to iris and ciliary body
CN IV
Trochlear Nerve
Motor nerve to 1 of 6 extrinsic eye muscles
CN V
V_1 Ophthalmic branch
- Sensory nerve (touch, pain, etc.) from upper third of face
V_2 Maxillary Branch
- Sensory nerve from middle third of face and upper teeth
V_3 Mandibular Branch
- sensory nerve from lower third of face and lower teeth
- motor nerve to muscles of mastication
CN VI
Abducens Nerve
- Motor nerve to 1 of 6 extrinsic eye muscles
CN VII
Facial Nerve
- Sensory Nerve for taste (from taste buds)
- Motor nerve to muscles of facial expression
- Parasympathetic nerves to lacrimal, nasal, and most salivary glands
CN VIII
Vestibulocochlear Nerve
- sensory nerve for hearing and balance (from Inner ear)
CN IX
Glossopharyngeal Nerve
- sensory nerve from posterior tongue (touch, pain, etc.), pharynx, and some taste buds
- motor nerve to muscles involved in swallowing
- Parasympathetic nerve to one salivary gland
CN X
Vagus Nerve
- Sensory nerve from thoracic and abdominal organs
- parasympathetic nerve to thoracic and abdominal organs
CN XI
Accessory Nerve
- Motor Nerve to muscles of larynx and pharynx, trapezius, and sternocleidomastoid
CN XII
Hypoglossal Nerve
- Motor nerve to muscle of the tongue