Neoplasia Flashcards
What is P-selectin?
Cell adhesion molecule: it marginates neutrophils during acute inflammation
What two cells have abundant telomerase expression?
Cancer cells and germ cells. Somatic cells do not normally express telomerase
What gene is the catalytic subunit of telomerase?
Human telomerase reverse transcriptase
How do DNA viruses cause cancer?
They inactivate tumor suppressor genes
HPV PATHOGENESIS IS/?
E6 and E7 genes of HPV 16 bind p53 and pRb
Carcinoma in situ
Cancers that don’t penetrate the basement b membrane
Koilocytosis
Presence of squamous cells with perinuclear halos and nuclear changes. Indicative of HPV infection
What ion is adhering dependent on?
Calcium
What is function of Lysol hydroxylase?
Post translational modification of collagen
What kind of tumors exhibit Anaplasia?
High. Grade- they lack differentiated features
Papillomatosis
Fond-like structures
Medullary
Soft cellular tumor
Scirrhous or desmoplastlc
Dense fibrous stroma
Colloidal carcinoma
Secretes abundant mucus
What compound is normally seen produced inlung cancers?
Corticotropin (ACTH)