Neoplasia Flashcards

1
Q

What is P-selectin?

A

Cell adhesion molecule: it marginates neutrophils during acute inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What two cells have abundant telomerase expression?

A

Cancer cells and germ cells. Somatic cells do not normally express telomerase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What gene is the catalytic subunit of telomerase?

A

Human telomerase reverse transcriptase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How do DNA viruses cause cancer?

A

They inactivate tumor suppressor genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

HPV PATHOGENESIS IS/?

A

E6 and E7 genes of HPV 16 bind p53 and pRb

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Carcinoma in situ

A

Cancers that don’t penetrate the basement b membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Koilocytosis

A

Presence of squamous cells with perinuclear halos and nuclear changes. Indicative of HPV infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What ion is adhering dependent on?

A

Calcium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is function of Lysol hydroxylase?

A

Post translational modification of collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What kind of tumors exhibit Anaplasia?

A

High. Grade- they lack differentiated features

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Papillomatosis

A

Fond-like structures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Medullary

A

Soft cellular tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Scirrhous or desmoplastlc

A

Dense fibrous stroma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Colloidal carcinoma

A

Secretes abundant mucus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What compound is normally seen produced inlung cancers?

A

Corticotropin (ACTH)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What would happen to adrenal function in adrenal and pituitary metastases? What disease is this?

A

Adrenal Function would be lost- Addison’ s disease

17
Q

Alpha fetal protein is a tumor marker for what carcinomas?

A

Yolk Sac and Hepatocellular

18
Q

Calretinin is a tumor marker for what cancer?

A

Mesothelioma

19
Q

Synaptophysin is a marker for what tumour?

A

Neuroendocrine- including small cell carcinoma of theking

20
Q

Carcinoembryonic antigen is a marker for what cancer?

A

COLON and many others

21
Q

How do RAD51 and BRA proteins 1&2 work together?

A

brca binds RAD to meditate double strand repair breaks

22
Q

Chondroma

A

Benign cartaliginous tumor

23
Q

Hamartoma

A

Disorganized normal tissue

24
Q

What are three features ofAtaxia Telangiectasia

A
  1. Cellular degeneration
  2. Immunological abnOrmalities
  3. Predisposition to cancer
25
Q

What cancer are albinism patients at risk for?

A

Squamous cell carcinoma of skin.

They do not have a defect in DNA excision repair

26
Q

Describe anemia of a paraneoplastic syndrome.

A

The anemia is Neolithic and normochromic. Fe deficiency anemia normally I seen when the cancer is bleeding into the GI tract.

27
Q

What are some chromosome alterations seen in solid tumors?

A
  1. Homogenous staining regions
    2; abnormal banding regions on fhromoome
    3, double minutes
28
Q

What symptoms are seen in carcinoid syndrome and why?

A

Serotonin, histamine and bradykinin are released and cause flushing, bronchial wheezing, watery diarrhea and abdominal colic

29
Q

Where are carcinoid normally found?

A

Submucosa of the intestine

30
Q

alpha-fetotprotein is a tumor marker for what cancers?

A

Hepatocellular carcinomas

Testicular CArcinomas

31
Q

what is a choristoma?

A

benign mass composed of tissues not from the site of origin

32
Q

what pathway of is activated by APC?

A

WNT signaling