Breast

Question 1

What is gynectomasia? it s cause?

Answer 1

adult male breast enlargement; increase in the estrogen/amdrogen ratio

Question 2

What metabolic disorders are associated with increased conversion of androstenedione into estrogens? (as seen in males)

Answer 2

Liver disease (Micronodular Cirrhosis- impairs hepatic estrogen metabolism) and Hyperthyroidism

Question 3

What are the classes of non comedo intraductal carcinoma?

Answer 3

Micropapillary, Cribriform, and Solid

Question 4

Which DCIS type is likely to produce a desmoplastic response in surrounding tissue?

Answer 4

Comedo- produces a dense collagenous stroma

Question 5

What is the gene and the protein associated with HER2-neu that can be detected in HER2/neu overexpression in FISH?

Answer 5

c-erbB2 protein and the HER2/neu gene

Question 6

What does colloid carcinoma feature?

Answer 6

Mucin production

Question 7

What is Medullary carcnioma conmposed of ?

Answer 7

sheets of invasive and pleomorphic cells

Question 8

What cells are proliferative in Phyllodes Tumor?

Answer 8

Spindly stromal cells

Question 9

What are 2 major clinical manifestations of inflammation of the breast?

Answer 9

Pain with breast enlargement