NEOPLASIA-2

Question 1

◦Symptom complexes in cancer-bearing individuals that cannot readily be explained, either by the local or distant spread of the tumor or by the elaboration of hormones indigenous to the tissue from which the tumor arose

Answer 1

Paraneoplastic Syndromes

Question 2

Identify the neurofilament used to diagnose the following tumor

Carcinoma

Answer 2

Cytokeratin

Question 3

Identify the neurofilament used to diagnose the following tumor

Astrocytomas, ependymomas

Answer 3

Glial fibrillary acid protein (GFAP)

Question 4

1. Identify which cancer exhibits this neuromyopathic paraneoplastic syndrome

gray-black patches of verrucous hyperkeratosis

2. Which benign condition is associated with this skin lesion?

Answer 4

1. Gastric carcinomas
2. obesity and insulin resistance

Question 5

What’s the tumor marker for the following condition?

Small cell cancer of lung

Neuroblastoma

Answer 5

Neuron specific enolase

Question 6

Most common overall cancer due to ionizing radiation

Answer 6

Leukemia especially Acute myeloblastic leukemia (AML) and chronic myelogenous leukemia (CML)

Question 7

Identify the intermediate filament used to diagnose the following tumor

Sarcoma

Answer 7

Vimentin

Question 8

What’s the tumor marker for the following condition?

Trophoblastic tumors

Answer 8

Human chorionic gondatropin

Question 9

1. Factor responsible for paraneoplastic hypercalcemia of malignancy
2. most common lung neoplasm associated with hypercalcemia

Answer 9

1. parathyroid hormone–related protein (PTHRP)
2. Squamous cell carcinoma

Question 10

Bland, small, nonbacterial fibrinous vegetations on the cardiac valve leaflets (more often on left-sided valves), particularly in individuals with advanced mucin-secreting adenocarcinomas.

Answer 10

Nonbacterial thrombotic endocarditis (Marantic endocarditis)

Question 11

What is this sign called?

Which condition is it associated with?

Sudden onset of multiple seborrheic keratoses

Answer 11

Leser-Trélat sign

GI adenocarcinomas and other visceral malignancies

Question 12

Identify the tumor associated with the following microorganism

Schistosoma haematobium

Answer 12

SCC of the urinary bladder

Question 13

List 5 distinguishing features of Myasthenia Gravis and Lambert Eaton Syndrome.

Answer 13

Question 14

1. Identify the cancer resulting from exposure to the following chemical carcinogen

ß-naphthylamine (anniline dyes) and aromatic amines

2. What is the other chemical carcinogen that causes the same cancer?

Answer 14

1. Transitional cell carcinoma
2. Cyclophosphamide

Question 15

Study grading and staging on slide 28-30 of Neoplasia-5 powerpoint

Answer 15

Slide 28-30 of Neoplasia-5 powerpoint

Question 16

most common anemia in malignancy

Answer 16

Anemia of chronic disease (ACD)

Question 17

Identify the tumor associated with the following microorganism

Helicobacter pylori

Answer 17

adenocarcinoma and low-grade malignant lymphoma of the stomach

Question 18

Identify the cancer resulting from exposure to the following chemical carcinogen

Aflatoxin from Aspergillus

Answer 18

Hepatocellular carcinoma

Question 19

Identify the cancer resulting from exposure to the following chemical carcinogen

Diethylstilbestrol (DES)

Answer 19

Clear cell adenocarcinoma of the Cervix

Question 20

Pure red cell aplasia is a form of paraneoplastic syndrome associated with which malignancy?

Answer 20

Thymoma

Question 21

What’s the tumor marker for the following condition?

Hepatocellular carcinoma

Answer 21

Alpha fetoprotein

Question 22

Identify the tumor associated and mechanism of microbial carcinogenesis

HPV 16 AND 18

Answer 22

Tumors- Squamous cell carcinoma of Cervix, vagina, anus, larynx and oropharynx

Mechanism - E6 inhibits p53; E7 inhibits RB1

Question 23

1. Cause of carcinogenity of UV-B light

Answer 23

formation of pyrimidine dimers in DNA.

Question 24

1. Identify which cancer exhibits this neuromyopathic paraneoplastic syndrome

Eaton Lambert Syndrome

2. What is the underlying mechanism?

Answer 24

1. Small cell carcinoma of lung
2. Antibodies directed against presynaptic calcium channels

Question 25

What’s the tumor marker for the following condition?

Prostatic adenocarcinoma

Answer 25

Prostatic acid phosphatase

Prostate specific antigen

Question 26

1. Identify this condition
2. Which cancer is it associated with?
3. List the 3 changes that characterize this condition?

Answer 26

1. Hypertrophic osteoarthropathy
2. Bronchogenic carcinoma

◦Answer to Q3.

(a) periosteal new bone formation, primarily at the distal ends of long bones, metatarsals, metacarpals, and proximal phalanges;

◦(b) arthritis of the adjacent joints

(c) clubbing of the digits

Question 27

List 2 paraneoplastic syndromes resulting from elaboration of tumor products that activate clotting

Answer 27

1. Trousseau Phenomenon (superficial migratory thrombophlebitis) in pancreatic carcinoma
2. DIC- acute promyelocytic anemia

Question 28

Identify the neurofilament used to diagnose the following tumor

Uterine leiomyoma, rhabdomyosarcoma

Answer 28

Desmin

Question 29

List examples of ionizing radiation induced cancers

Answer 29

1. Leukemias
2. Papillary thyroid carcinoma
3. Lung, breast, and salivary gland cancers

Question 30

Name 4 neuromuscular paraneoplastic syndromes assoc with small cell lung cancer

Answer 30

Lambert Eaton Syndrome

Opsoclonus myoclonus ataxia syndrome

Paraneoplastic cerebellar degeneration

Paraneoplastic encephalomyelitis

Question 31

1. progressive loss of body fat and lean body mass accompanied by profound weakness, anorexia, and anemia
2. Factors responsible for cachexia

Answer 31

1. Cachexia
   2a. TNF
   2b. proteolysis-inducing factor(PIF)
   2c. lipid-mobilizing factor(LMF)

Question 32

Mechanism of damage by ionizing radiation

Answer 32

hydroxyl free radical injury of DNA

Question 33

Identify the tumor associated and mechanism of microbial carcinogenesis

HTLV-1

Answer 33

Tumor - Tcell leukemia/lymphoma

Mechanism- Activates TAX gene