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Nefrología > Nefropatías intersticiales > Flashcards

Nefropatías intersticiales Flashcards

1
Q

Clasificación general nefritis intersticiales

A

Agudas

Crónicas

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2
Q

Principal causa de NIA

A

Fármacos >75%

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3
Q

Origina FRA

A

NIA

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4
Q

FRA en NIA

A
  1. FRA no oligúrico
  2. No HTA
  3. No afectación glomerular: no proteinuria
  4. No hematuria
  5. SÍ leucocituria: cilindros leucocitarios en orina
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5
Q

Causas de NIA

A
  1. Fármacos >75%
  2. Infecciones 10%
  3. Idiopáticas 10%
  4. Enf sistémicas 10: LES, sarcoidosis, sjögren, IgG4
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6
Q

Fármacos causantes de nefritis intersticial aguda

A

ATB:
AINES: 5-aminosalicilatos
IBP
Checkpoint inhibitors

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7
Q

Fármacos que dan NIA >florida

A

ATB

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8
Q

Hipomagnesemia

A

IBP

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9
Q

Fisiopatogenia de NIA

A

Inmunidad celular: fármacos unidos a MBT activan a linf T autorreactivos
Infil linfocitos macrofagos: cit, Fc: Fibrosis irreversible

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10
Q

Respuesta a fármacos

A

Tras reexposición

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11
Q

Tríada NIAF

A

Fiebre
Rash
Eosinofilia
+aumento urea, cr, leucocituria, cilindros

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12
Q

Síntoma >frec NIAF

A

Artralgias

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13
Q

Confirma diagnóstico NIAF

A

Biopsia

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14
Q

Tx NIAF

A

Retirar fármaco
Corticoides de forma muy PRECOZ!
–choque IV 3 dosis
–oral 4-6 semanas

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15
Q

Fiebre muy lta o mucos neutrofilos

A

NIA por infeccion

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16
Q

Tx NIA infección

A

Tx ATB

CI Corticoides

17
Q

NIA idiopática

A
  • Autoinmune: anticuerpos anti-MBT

- Sdr TINU: corticoides

18
Q

Clínica NIC

A 
-Sdr constitucional
Poliuria, polidipsia, nicturia
Hipotensión: pierde sal
Proteinuria escasa con LEUCOCITURIA
Anemia
Acidosis metabólica
19
Q

Etiología NIC

A
  1. Enf sistémicas: sarcoidosis, sjögren, hipercalcemia crónica, hipopotasemia
  2. Genético: hiperuricemia y gota precoz
  3. Tóxico: plomo, analgésicos
20
Q

NIC por plomo provoca

A

Hiperuricemia

Crisis de gota

21
Q

Principal causa de NIC

A

AINES

22
Q

Exposición a plomo

A

Soldadores
Pinturas
ALcoholes ilegales

23
Q

Quelante de plomo

A

EDTA

24
Q

Litio provoca

A

DI nefrogénica

25
Q

Acido aristolóquico

A

Carcinógeno

Nefrología (13 decks)

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