Naloxone

Question 1

Naloxone

Class

Answer 1

Narcotic antagonist

Question 2

Naloxone

Description

Answer 2

Effective in management and reversal of overdoses caused by narcotics or synthetic narcotic agents

Question 3

Naloxone

Presentation

Answer 3

Ampoules 0.4mg in 1mL (400mcg/1mL) or Pre-filled syringe

Question 4

Naloxone

Administration

Answer 4

Intravenous (IV)
Intraosseous (IO)
Intramuscular (IM)
Subcutaneous (SC)
Intranasal (IN)

Question 5

Naloxone

Indications

Answer 5

Inadequate respiration and/or ALoC following known or suspected narcotic overdose

Question 6

Naloxone

Contraindications

Answer 6

KSAR

Question 7

Naloxone

Dosage

Answer 7

Adult:

0. 4mg IV/IO/IM/SC. Repeat after 3min if indicated to Max 2mg.
1. 8mg IN. Repeat x 1 after 3 mins prn

Paed:
0.01mg/Kg (10mcg/Kg) IV/IO/IM/SC.
0.02mg/kg (20mcg/kg) IN
Repeat dose prn to maintain opoid reversal to max 0.1mg/Kg or 2mg

Question 8

Naloxone

Pharmacology

Answer 8

Narcotic antagonist

Reverse the respiratory depression and analgesic effect of narcotics

Question 9

Naloxone

Side Effects

Answer 9

Acute reversal of narcotic effect ranging from nausea & vomiting to agitation & seizures

Question 10

Naloxone

Additional Info

Answer 10

Use with caution in pregnancy
Administer with caution to patients who have taken large dose of narcotics or are physically dependent.
Rapid reversal will precipitate acute withdrawal syndrome.
Prepare to deal with aggressive patients