Clopidogrel

Question 1

Clopidogrel Class

Answer 1

Platelet aggregator inhibitor

Question 2

Clopidogrel Description

Answer 2

An inhibitor of platelet function

Question 3

Clopidogrel Administration

Answer 3

Orally (PO)

Question 4

Clopidogrel Indications

Answer 4

STEMI if patient is not for PPCI

Question 5

Clopidogrel Contraindications

Answer 5

KSAR
Active Pathological Bleeding
Severe Liver Impairment

Question 6

Clopidogrel Doseage

Answer 6

300mg PO

≥ 75yrs 75mg PO

Question 7

Clopidogrel Pharmacology

Answer 7

Clopidogrel selectivelyinhibits the binding of adenosine diphosphate (ADP) to its platelet receptor, and the subsequent ADP - mediated activation of the GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Biotransformation of clopidogrel is necessary to produce inhibition of platelet aggregation. Clopidogrel acts by irreversibly modifying the platelet ADP receptor

Question 8

Clopidogrel Side Effects

Answer 8

Abdominal Pain
Dyspepsia
Diarrhoea

Question 9

Clopidogrel Additional Info

Answer 9

If the patient has been loaded with an anti-platlet medication (other than Aspirin), prior to the arrival of the practitioner, the patient shlould not have Clopidogrel administered