Midaz

Question 1

Midazolam Solution

Class

Answer 1

Benzodiazepine

Question 2

Midazolam Solution

Description

Answer 2

It is a potent sedative agent.

Clinical experience has shown Midazolam to be 3 to 4 times more potent per mg as Diazepam

Question 3

Midazolam Solution

Presentation

Answer 3

Ampoule: 10mg in 2ml ampoule or 10mg in 5ml
Buccal liquid: 50mg in 5ml
PFL: 2.5mg in 0.5ml, 5mg in 1ml, 10mg in 1ml, 10mg in 2ml

Question 4

Midazolam Solution

Administration

Answer 4

Intravenous (IV)
Intraosseous (IO)
Intramuscular (IM)
Buccal (BU)
Intranasal (IN) (50% in each nostril)

Question 5

Midazolam Solution

Indications

Answer 5

Seizures
Combative with Hallucinations or paranoia and risk to self or others.
Sedation (following medical advice)

Question 6

Midazolam Solution

Contraindications

Answer 6

Shock
Respiratory depression
KSAR
Depressed vital signs or alcohol related altered level of consciousness

Question 7

Midazolam Solution

Dosage

Answer 7

Adult:
Seizure: 2.5mg IV or 5mg IM or 10mg BU or 5mg IN (repeat X 3 prn)
Behavioural Emergency : 5mg IN/IM (Rpt x 2) (Medical Oversight)
Palliative care: 2.5mg SC, alternatively 2.5-5mg Buccal rpt x1

Paed:
Seizure: 0.2mg/Kg IN or 0.1mg/Kg IV/IO (repeat X 3 prn)
Behavioural Emergency: (Medical Oversight) 0.1mg/kg (rpt x 2)

Question 8

Midazolam Solution

Pharmacology

Answer 8

It affects the activity of a chemical that transmits impulses across nerve synapses called Gamma-AminoButyric Acid (GABA). GABA is an inhibitory neurotransmitter. Midazolam works by increasing the effects of GABA at these receptors

Question 9

Midazolam Solution

Side Effects

Answer 9

Respiratory Depression
Headache
Hypotension
Drowsiness

Question 10

Midazolam Solution

Additional Info

Answer 10

Midazolam IV should be titrated to effect.
Ensure oxygen and resuscitation equipment are available prior to administration.
The max dose of Midazolam includes that administered by caregiver prior to arrival of practitioner