Chlorphenamine

Question 1

Chlorphenamine Class

Answer 1

Antihistamine

Question 2

Chlorphenamine Description

Answer 2

H1 antagonist to counteract the effects of histamine release

Question 3

Chlorphenamine Presentation

Answer 3

10mg in 1 ml

4mg tablet

Question 4

Chlorphenamine Administration

Answer 4

PO / IM / IV (IV Deliver over 1 Minute)

Question 5

Chlorphenamine Indications

Answer 5

Anaphylaxis or allergic reaction

Question 6

Chlorphenamine Contra-indications

Answer 6

KSAR

Pre-coma States

Question 7

Chlorphenamine Dose Adult

Answer 7

Adult:
Allergic Reaction
Mild:                 - 4mg PO
Moderate:        - 4mg PO, 10mg IV/IM
Severe:            - 10mg IV/IM

Question 8

Chlorphenamine Dose Paediatric

Answer 8

Paediatric:
Allergic Reaction
Mild: 6-11years - 2mg PO
≥12 years - 4mg PO

Moderate: <1 year 0.25mg/kg IV/IM
1 - 5 years 2.5mg IM/IV
6 - 11 years 2mg PO, 5mg IV/IM
≥12 years 4mg PO, 10mg IV/IM

Severe/: <1 year 0.25mg/kg IV/IM
Anaphylaxis 1 - 5 years 2.5mg IM/IV
6 - 11 years 5mg IV/IM
≥12 years 10mg IV/IM

Question 9

Chlorphenamine Pharmacology

Answer 9

Chlorphenamine is a potent antihistamine (H1-receptor antagonist). Antihistamines diminish or abolish the action of histamine in the body by competitive reversible blockade of histamine 1 receptor sites on tissues.
Chlorphenamine also has Anticholinergic activity

Question 10

Chlorphenamine Side Effects

Answer 10

Causes Drowsiness and patients receiving it should not drive or operate machinery

Question 11

Chlorphenamine Additional Info

Answer 11

Use with caution in:
Epilepsy / Prostatic Hypertrophy / Glaucoma / Hepatic Disease / Bronchitis / Bronchiectasis / Thyrotixicosis / Raised intra-occular pressure / Severe Hypertension / Cardiovascular Disease / Bronchial Asthma