Ibuprofen

Question 1

Ibuprofen

Class

Answer 1

Non-steroidal anti-inflammatory drugs (NSAIDs)

Question 2

Ibuprofen

Description

Answer 2

It is used to reduce mild to moderate pain

Question 3

Ibuprofen

Presentation

Answer 3

Suspension 100mg in 5ml and 200mg in 5ml

200mg and 400mg tablets

Question 4

Ibuprofen

Administration

Answer 4

Orally (PO)

Question 5

Ibuprofen

Indications

Answer 5

Mild to moderate pain

Question 6

Ibuprofen

Contraindications

Answer 6

Not suitable for children under 3 months
Patient with history of asthma exacerbated by aspirin
Pregnancy
Peptic ulcer disease
Known Renal Failure
Known Severe Liver Failure
Known Severe Heart Failure
Concurrent NSAID use
KSAR

Question 7

Ibuprofen

Dosages

Answer 7

Adult: 400mg (PO) mild pain
600mg (PO) moderate pain

Paed: 10mg/Kg (PO) to max 400mg

Question 8

Ibuprofen

Pharmacology

Answer 8

Suppresses prostaglandins, which cause pain via its inhibition of cyclooxygenase (COX).
Prostaglandins are released by cell damage and inflammation

Question 9

Ibuprofen

Side Effects

Answer 9

Skin Rashes,
GI Intolerance and bleeding.

LTSE - Occasionally Gi Bleeding and ulceration occurs.
May also cause acute renal failure, interstitial nephritis and NASID associated nephropathy

Question 10

Ibuprofen

Additional Info

Answer 10

If ibuprofen administered in previous 6 hours, adjust the dose downward by the amount given by other sources resulting in a maximum of 10mg/Kg or 400mg for paediatrics.
Caution with significant burns or poor perfusion due to risk of kidney failure.
Caution if on oral anitcoagulant (e.g. Warfarin, Riveroxaban, Apixaban, Edoxaban) due to increased bleeding risk.
Ibuprofen may be combined with Paracetamol for synergic effect