Multiple Sclerosis and Inflammatory CNS Diseases Flashcards
What is multiple sclerosis?
An autoimmune, inflammatory demyelinating disorder of the CNS.
In MS, patches of scar tissue known as plaques form over the demyelinated areas preventing what?
Nerve communication.
Progression of symptoms in MS correlates to what?
Plaque dissemination of areas of the brain/spinal cord controlling affected areas.
MS is more common in which sex?
Females 3:1.
Initial presentation of MS typically in which decades?
30s and 40s.
What are the various clinical courses of MS?
- Relapsing remitting.
- Secondary progressive.
- Progressive relapsing.
- Primary progressive.
What are the clinical features of Multiple Sclerosis?
- Pyramidal dysfunction.
- Optic neuritis.
- Sensory symptoms.
- Lower urinary tract dysfunction.
- Cerebellar and brain stem features.
- Cognitive impairment.
What are the symptoms of pyramidal dysfunction seen in MS?
In the extensors of upper limbs and the flexors of lower limbs, there will be:
- Increased tone.
- Spasticity.
- Weakness.
Describe optic neuritis?
Painful progressive visual loss over 1-2 weeks.
Often associated with MS.
If unilateral, RAPD (relative afferent pupillary defect) may be observed.
Most cases improve over time.
What are the sensory symptoms experienced in MS?
- Pain.
- Paraesthesia (pins + needles).
- Dorsal column loss: impaired/lost ability to sense vibration and proprioception.
- Numbness.
- Trigeminal neuralgia.
If cerebellar dysfunction is present in MS, what signs will be observed?
- Ataxia.
- Intention tremor.
- Nystagmus.
- Past pointing.
- Pendular reflexes.
- Dysdiadochokinesia.
- Dysarthria.
What is ataxia?
Lack of voluntary coordination of muscle movements e.g. gait abnormality, changes to speech and eye movement abnormalities.
What is past pointing?
Pointing beyond the finger in the finger-nose test.
What are pendular reflexes?
When reflex is elicited, limb stimulated swings like a pendulum.
What is dysdiadochokinesia?
Inability to perform rapid alternating movement, e.g. tapping the right hand fast on the back of the left hand.
What is dysarthria?
Difficult or unclear articulation of speech that is otherwise normal.
What features of brain stem dysfunction may be seen in MS?
- Diplopia: CN VI palsy.
- Facial weakness: CN VII palsy.
What is internuclear ophthalmoplegia?
Disorder of conjugate lateral gaze resulting in impaired adduction.
Attempting to gaze contralaterally (in relation to affected eye) results in minimal adduction - if any.
The contralateral eye abducts with nystagmus.
What causes internuclear ophthalmoplegia?
Injury or dysfunction (MS) in the medial longitudinal fasciculus.
What signs and symptoms are seen in internuclear ophthalmoplegia?
- Distortion of binocular vision.
- Failure of adduction resulting in diplopia.
- Nystagmus in adducing eye.
- Eye lag.