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MSCT > MSCT Week 6: Neoplasms of the Skin > Flashcards

MSCT Week 6: Neoplasms of the Skin Flashcards

1
Q

Question 1

A

This is a common benign proliferation of keratinocytes Seborrheic keratosis

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2
Q

Seborrheic keratosis Clinical Description

5 listed

A
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3
Q

Sign of Leser-Trelat

Step 1

A
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4
Q

Identify

A

Seborrheic Keratosis

  • well demarcated
  • mushroom epidermis
  • horn cysts(spaces in the tumor filled with keratin)
  • benign
  • regular looking cells
  • wouldn’t see a lot of mitosis
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5
Q

A benign proliferation of keratinocytes

A

Seborrheic keratosis

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6
Q

What is this?

A
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7
Q

Mitoses and atypia in seborrheic keratosis

A
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8
Q

What is this depicting?

A

Mitoses and atypia

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9
Q

Question 2

A

C is correct

A is Basal cell Carcinoma

B is a Melanoma

C is a benign Nemus

D Seborrheic Keratosis

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10
Q

Nevus definition

What does nevus mean?

What is a Nevi?

A
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11
Q

Nevus clinical characteristics

A
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12
Q

Benign Pigmented Lesions AKA

A

Nevus or Naevi

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13
Q

Identify

A
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14
Q

Identify

A
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15
Q

Identify

A

symmetrical

melanocytes get smaller with depth

would not expect to see atypia or mitoses

in a benign nevus

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16
Q

Benign Nevus Histology Characteristics

6 listed

A
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17
Q
A

Benign Naevia melanocytes get smaller as you go down

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18
Q

Question 3

Which of the following lesions is of most concer?

A

Correct Answer: A

A Melanoma

B Seborrheic Keratosis

C & D Benign Melanocytic Lesions

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19
Q

ABCDE of Melanoma

A
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20
Q

Subtypes of Melanoma

4 listed

A
  • Superficial Spreading Melanoma
  • Nodular Melanoma
  • Acral Lentiginous Melanoma
  • Lentig maligna Melanoma
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21
Q

Lentigo Maligna Melanoma

A
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22
Q

Acral Lentigous Melanoma

A
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23
Q

Nodular Melanoma

A

more deadly spreads vertically

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24
Q

Superficial Spreading Melanoma

A
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25
Q
A
  • Melanoma
  • nests of melanocytes (should be in basal layer but are extending up through the epidermis)
  • Atypical big melanocytes
  • Mitoses
  • Pagetoid spread of melanocytes (upward spread of melanocytes
  • melanocytes dont get smaller deeper in the dermis
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26
Q
A

Melanoma

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27
Q

Mitoses in melanoma

A
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28
Q

Histologic Features of Melanoma vs Naevi

A
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29
Q

Question 4

A
  • Depth of invasion
  • Tumor thickness is the most important feature of melanoma
  • 10 year survival decreases with melanoma depth
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30
Q

Mutation common in Melanoma

A

BRAF V600E

31
Q

Pharmacotherapy of Melanoma

A
32
Q

Describe all lesions

A

A Crusted Plaque

B multicolored hyperpigmented shiny plaque

C shiny Vesicle with telangiectasia

D cryterraform hyperkeratotic nodule

33
Q

Question 5

A

Correct Answer: C

A Squamous cell carcinoma

B Melanoma

C Basal Cell Carcinoma

D Squamous cell carcinoma

34
Q

Clinical Features of Basal Cell Carcinoma

6 listed

A
35
Q

Question 6

A

Correct answer: A

A Basal Cell Carcinoma

B Squamous cell Carcinoma

C Melanoma

36
Q

Basal Cell Carcinoma Histological Features

5 listed

A
  • basaloid (blue)
  • basaloid tumor islands
  • artifactual clefting around the nests
  • nests themselves have peripheral palisading nuclei
  • mucin blue stringy material
37
Q
A

Basal Cell Carcinoma

38
Q

Basal Cell carcinoma Clinical Features

4 listed

A
39
Q

Basal Cell Carcinoma PAthogenesis

A

Sun exposure

Genetic factors may also play a role

40
Q

What is this?

A

Actinic Keratosis

41
Q
A
42
Q

Histological Features of Actinic Keratosis

5 listed

A
43
Q

Question 8

A

Correct Answer: D

a premalignant lesion caused by sun exposure and if left untreated about 10% would transform into squamous cell carcinoma

44
Q

Actinic Keratosis Clinical Features

A
45
Q

Describe lesions? Which is Malignant?

A

Pink or red plaque some red scale

next lesion

red plaque with white crusted scale

46
Q
A

epidermis does not look normal

diffusely enlarged keratinocytes

full thickness atypia of the epidermis and mitoses

47
Q
A

squamous cell carcinoma

48
Q

Squamous Cell Carcinoma Histological Features

A
49
Q

Squamous Cell Carcinoma Clinical Features

5 listed

A
50
Q

Identify

A

squamous cell carcinoma is very pink because it is keratinizing

Keratin pearls

51
Q

Histological Features of Invasive Squamous Cell Carcinoma

A
52
Q

Invasice Squamous Cell Carcinoma Clinical Characteristics

A
53
Q

Invasive Squamous Cell Carcinoma details

4 listed

A
54
Q

Pathogenesis of Invasive Squamous Cell Carcinoma

A
55
Q

Etiology of Skin Cancer

A

UV Radiation

UVA tanning and photoaging

UVB causes sunburn

UVC filtered out by atmosphere

56
Q

How does UV Radiation damage DNA

A
57
Q

Xeroderma Pigmentosum

A
58
Q

Pyogenic Granuloma AKA

A

Lobular Capillary Hemangioma

59
Q

Pyogenic Granuloma Clinical Features

A
60
Q

Infantile Hemangiomas Clinical Features

A
61
Q

Hemangiomas Additional details

A
62
Q

Cherry Angioma Clinical Features

A
63
Q

Glomus Tumor Clinical Features

4 listed

A
64
Q

Identify

A

Kaposi Sarcoma

related to HHV8 Viral Infection

purplish plaques in immunosuppressed patients

purple plaques or nodules

treatment reverse immunosuppression

65
Q

Histological Features of Kaposi Sarcoma

A
66
Q

Herpes Virus 8

A

Kaposi Sarcoma

67
Q

Angio Sarcoma Clinical Features

4 listed

A
68
Q

Seborrheic Keratosis Summary

A

leser trelot sign be concerned

69
Q

Nevus Sumary

A
70
Q

Melanoma Summary

A
71
Q

Basal Cell Carcinoma Summary

A
72
Q

Actinic Keratosis to Squamous Cell Carcinoma Summary

A
73
Q

summary of Vascular Lesions

A

pyogenic granuloma

hemangioma

cherry angioma

Kaposi Sarcoma malignant vascular neoplasm herpes virus 8 reverse immunosuppresion

Glomus Tumor smooth muscle capillary cells pain in exposure to cold

MSCT (30 decks)

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