MSCT Week 6: Bullous Dermatoses and drug Reactions Flashcards

1
Q

Important things to note in autoimmune blistering disease

A
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2
Q
A
  • dehydration (loss of fluids)
  • Infection
  • temperature regulation
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3
Q
A

tense bullas or vesicles on background of erythema

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4
Q
A

subepidermal split with eosinophils

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5
Q

Direct immunofluoresence testing

A

incubate patients skin with an immunofluorescent antibody to see if the antigen in question is there

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6
Q

Review of junctions

5 listed

A
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7
Q

subepidermal split

A
  • Bp230
  • BP180

are the components of the desmosome affected in this disorder

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8
Q

Describe

A

ulcerating plaque 1 or 2 blisters that are flaccid

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9
Q

Nikolsky’s Sign

A
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10
Q

Positive Nikolsky’s sign

A
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11
Q

in addition to… physical exam finds

A
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12
Q

Identify histological features

A
  • intraepidermal split
  • suprabasalar split
  • acantholysis (drifting apart of cells)
  • desmosomes are the target
  • desmoglein 1 & 3 are the targets of the autoantibodies
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13
Q

Identify

A

intraepidermal split

Pemphigous Bulgaris

desmosomes attacked desmoglein 1 & 3

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14
Q

way to remember pephigous vulgaris

A

disease of younger people

tombstoning of cells (is more deadly)

young people tend to use bad words (vulgar words)

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15
Q

Pephigous Vulgaris vs Bullous Pemphigoid

A
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16
Q

Pemphigus vulgaris typically affects

A

Young people

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17
Q

Pemphigus vulgaris Mucosal Involvement

A

common (oral lesions present)

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18
Q

Pemphigus vulgaris antibodies against

A

Desmoglein 1 and 3 of desmosomes

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19
Q

Pemphigus vulgaris blistering pattern

A

intraepidermal superficial blisters

blisters are flaccid and rupture easily

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20
Q

Pemphigus vulgaris Nikolsky’s sign

A

Positive

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21
Q

Pemphigus vulgaris immunofluoresence

A

shows net like IgG

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22
Q

Pemphigus vulgaris Prognosis

A

Most patients die without treatment

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23
Q

Pemphigus vulgaris key characteristic

A

tombstone appearance of basal layer

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24
Q

Bullous Pemphigoid Typically Affects

A

Elderly

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25
Q

Bullous Pemphigoid Mucosal involvement

A

Rare (oral lesions absent)

26
Q

Bullous Pemphigoid autoantibody targets

A

antibodies against hemidesmosomes BP180 & BP230

27
Q

Bullous Pemphigoid blistering pattern

A

subepidermal deep blisters

blisters are tense and firm

28
Q

Bullous Pemphigoid Nikolsky’s sign

A

Negative

29
Q

Bullous Pemphigoid Immunofluoresence

A

shows linear IgG

30
Q

Bullous Pemphigoid Prognosis

A

prognosis is good most patients do well

31
Q

Bullous Pemphigoid key histologic feature

A

Eosinophilic infiltration seen on histology

32
Q
A

Case 1: Bullous Pemphigoid

Case 2: Pemphigous Vulgaris

33
Q

Question 1

A

Bullous Pemphigoid

34
Q

Question 2

A

Pemphigous Vulgaris

35
Q

Question 3

A

Bullous Pemphigoid

36
Q

Question 4

A

Bullous Pemphigoid

37
Q

Question 5

A

Pemphigous Vulgaris

38
Q

Question 6

A

Pemphigous Vulgaris

39
Q

Drug Eruptions

5+ listed

A
40
Q

Urticarial Eruptions Clinical Features

A
41
Q

Identify Histological features

A

slight edema in the epidermis

sparsely inflammatory

similar to spongiosis in the collagen called dermal edema

Urticaria

42
Q

Morbilliform Eruptions Clinical Features

A
43
Q

Urticaria vs Erythema Multiforme

A
44
Q

Erythema Multiforme distinct condition

A
45
Q

Erythema Multiforme Minor vs Major

A
46
Q

Erythema Multiforme Clinical Features

A
47
Q

Erythema Multiforme affects mostly?

A

Kids and Young Adults

48
Q

Erythema Multiforme Systemic symptoms?

A

Rarely

49
Q

Erythema Multiforme Herpes Virus induced Treated with

A

acyclovir prophylaxis

50
Q

Erythema Multiforme typically induced by?

A

Herpes Simplex Virus 1

51
Q

Question 8

A

EM Minor

52
Q

Sever Cutaneous Drug Reactions

A
53
Q

Drug Eruption Spectrum

A
54
Q

SJS/TEN Clinical Features

A
55
Q

Identify Histological Features

A

the entire epidermis is dead

very pink usually means dead

SJS/TEN

56
Q

Identify Histological Features

A

the entire epidermis is dead

very pink usually means dead

57
Q

Question 9

A
58
Q

Seriousness of SJS/TEN

A
59
Q

Question 10

A

This man died

60
Q

Morbilliform Eruptions Major Caused by

A

Penicillins

Cephalosporins

ABX

61
Q

Most Common Meds in SJS/TEN

A