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MSCT > MSCT Week 6: Bullous Dermatoses and drug Reactions > Flashcards

MSCT Week 6: Bullous Dermatoses and drug Reactions Flashcards

1
Q

Important things to note in autoimmune blistering disease

A
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2
Q
A
  • dehydration (loss of fluids)
  • Infection
  • temperature regulation
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3
Q
A

tense bullas or vesicles on background of erythema

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4
Q
A

subepidermal split with eosinophils

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5
Q

Direct immunofluoresence testing

A

incubate patients skin with an immunofluorescent antibody to see if the antigen in question is there

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6
Q

Review of junctions

5 listed

A
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7
Q

subepidermal split

A
  • Bp230
  • BP180

are the components of the desmosome affected in this disorder

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8
Q

Describe

A

ulcerating plaque 1 or 2 blisters that are flaccid

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9
Q

Nikolsky’s Sign

A
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10
Q

Positive Nikolsky’s sign

A
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11
Q

in addition to… physical exam finds

A
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12
Q

Identify histological features

A
  • intraepidermal split
  • suprabasalar split
  • acantholysis (drifting apart of cells)
  • desmosomes are the target
  • desmoglein 1 & 3 are the targets of the autoantibodies
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13
Q

Identify

A

intraepidermal split

Pemphigous Bulgaris

desmosomes attacked desmoglein 1 & 3

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14
Q

way to remember pephigous vulgaris

A

disease of younger people

tombstoning of cells (is more deadly)

young people tend to use bad words (vulgar words)

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15
Q

Pephigous Vulgaris vs Bullous Pemphigoid

A
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16
Q

Pemphigus vulgaris typically affects

A

Young people

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17
Q

Pemphigus vulgaris Mucosal Involvement

A

common (oral lesions present)

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18
Q

Pemphigus vulgaris antibodies against

A

Desmoglein 1 and 3 of desmosomes

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19
Q

Pemphigus vulgaris blistering pattern

A

intraepidermal superficial blisters

blisters are flaccid and rupture easily

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20
Q

Pemphigus vulgaris Nikolsky’s sign

A

Positive

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21
Q

Pemphigus vulgaris immunofluoresence

A

shows net like IgG

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22
Q

Pemphigus vulgaris Prognosis

A

Most patients die without treatment

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23
Q

Pemphigus vulgaris key characteristic

A

tombstone appearance of basal layer

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24
Q

Bullous Pemphigoid Typically Affects

A

Elderly

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25
Bullous Pemphigoid Mucosal involvement
Rare (oral lesions absent)
26
Bullous Pemphigoid autoantibody targets
antibodies against hemidesmosomes BP180 & BP230
27
Bullous Pemphigoid blistering pattern
subepidermal deep blisters blisters are tense and firm
28
Bullous Pemphigoid Nikolsky's sign
Negative
29
Bullous Pemphigoid Immunofluoresence
shows linear IgG
30
Bullous Pemphigoid Prognosis
prognosis is good most patients do well
31
Bullous Pemphigoid key histologic feature
Eosinophilic infiltration seen on histology
32
Case 1: Bullous Pemphigoid Case 2: Pemphigous Vulgaris
33
Question 1
Bullous Pemphigoid
34
Question 2
Pemphigous Vulgaris
35
Question 3
Bullous Pemphigoid
36
Question 4
Bullous Pemphigoid
37
Question 5
Pemphigous Vulgaris
38
Question 6
Pemphigous Vulgaris
39
Drug Eruptions 5+ listed
40
Urticarial Eruptions Clinical Features
41
Identify Histological features
slight edema in the epidermis sparsely inflammatory similar to spongiosis in the collagen called dermal edema Urticaria
42
Morbilliform Eruptions Clinical Features
43
Urticaria vs Erythema Multiforme
44
Erythema Multiforme distinct condition
45
Erythema Multiforme Minor vs Major
46
Erythema Multiforme Clinical Features
47
Erythema Multiforme affects mostly?
Kids and Young Adults
48
Erythema Multiforme Systemic symptoms?
Rarely
49
Erythema Multiforme Herpes Virus induced Treated with
acyclovir prophylaxis
50
Erythema Multiforme typically induced by?
Herpes Simplex Virus 1
51
Question 8
EM Minor
52
Sever Cutaneous Drug Reactions
53
Drug Eruption Spectrum
54
SJS/TEN Clinical Features
55
Identify Histological Features
the entire epidermis is dead very pink usually means dead SJS/TEN
56
Identify Histological Features
the entire epidermis is dead very pink usually means dead
57
Question 9
58
Seriousness of SJS/TEN
59
Question 10
This man died
60
Morbilliform Eruptions Major Caused by
Penicillins Cephalosporins ABX
61
Most Common Meds in SJS/TEN

MSCT (30 decks)

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