MSCT Week 6: Bullous Dermatoses and drug Reactions Flashcards
Important things to note in autoimmune blistering disease
- dehydration (loss of fluids)
- Infection
- temperature regulation
tense bullas or vesicles on background of erythema
subepidermal split with eosinophils
Direct immunofluoresence testing
incubate patients skin with an immunofluorescent antibody to see if the antigen in question is there
Review of junctions
5 listed
subepidermal split
- Bp230
- BP180
are the components of the desmosome affected in this disorder
Describe
ulcerating plaque 1 or 2 blisters that are flaccid
Nikolsky’s Sign
Positive Nikolsky’s sign
in addition to… physical exam finds
Identify histological features
- intraepidermal split
- suprabasalar split
- acantholysis (drifting apart of cells)
- desmosomes are the target
- desmoglein 1 & 3 are the targets of the autoantibodies
Identify
intraepidermal split
Pemphigous Bulgaris
desmosomes attacked desmoglein 1 & 3
way to remember pephigous vulgaris
disease of younger people
tombstoning of cells (is more deadly)
young people tend to use bad words (vulgar words)
Pephigous Vulgaris vs Bullous Pemphigoid
Pemphigus vulgaris typically affects
Young people
Pemphigus vulgaris Mucosal Involvement
common (oral lesions present)
Pemphigus vulgaris antibodies against
Desmoglein 1 and 3 of desmosomes
Pemphigus vulgaris blistering pattern
intraepidermal superficial blisters
blisters are flaccid and rupture easily
Pemphigus vulgaris Nikolsky’s sign
Positive
Pemphigus vulgaris immunofluoresence
shows net like IgG
Pemphigus vulgaris Prognosis
Most patients die without treatment
Pemphigus vulgaris key characteristic
tombstone appearance of basal layer
Bullous Pemphigoid Typically Affects
Elderly