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MSCT > MSCT Week 4: Bone Tumors > Flashcards

MSCT Week 4: Bone Tumors Flashcards

1
Q
A
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2
Q

Imaging Studies =

A

Gross Pathology

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3
Q

Initial evaluation

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4
Q

Categories of Radiological Lesions: Geographic

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5
Q

Categories of Radiological Lesions: Marginated

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6
Q

Categories of Radiological Lesions: Permeative

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7
Q

Categories of Radiological Lesions: Moth-eaten

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8
Q

Periosteal Reaction and tumor aggressiveness

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9
Q

Indolent/Likely Benign Tumors

4 listed

A
  • Geographic pattern
  • Marginated Pattern
  • Solid Periosteal Reaction
  • A clear demarcation between the lesion and normal bone
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10
Q

Aggressive/Likely Malignant Tumors

5 Listed

A
  • Permeative Pattern
  • Moth-eaten Pattern
  • Non-solid Periosteal Reaction
  • Soft Tissue Mass
  • Uncertain where legion ends and normal bone begins
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11
Q

Types of Bone Tumors

16 listed

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12
Q

Characteristics of Benign Bone Tumors

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13
Q

Characteristics of Malignant Bone Tumors

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14
Q

Clinicopathologic Classification of Bone Tumors

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15
Q

Bone-Forming Tumors Examples

3 listed

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16
Q

Osteoid Osteoma Risk Factors and prevalence

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17
Q

Osteoid Osteoma Description

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18
Q

Osteoid Osteoma Radiological Features

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19
Q

OSteoid Osteoma Histological Features

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20
Q

Pathology?

A

Osteoid Osteoma

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21
Q

Pathology?

A

Osteoid Osteoma

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22
Q

Osteoblastoma Risk Factors and prevalence

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23
Q

Osteoblastoma Radiological Features

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24
Q

Osteoblastoma Histopathology Features

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25
Q

Pathology?

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26
Q

Osteosarcoma General Features

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27
Q

Osteosarcoma Radiologic Features

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28
Q

Pathology?

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29
Q

Osteosarcoma Histological Features

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30
Q

Pathology?

A

Osteosarcoma

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31
Q

Osteosarcoma genetic alterations

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32
Q

low grade osteosarcoma

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33
Q

Fibrous Dysplasia General Features

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34
Q

Fibrous Dysplasia Radiological Features

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35
Q

Fibrous Dysplasia Histological Features

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36
Q

Fibrous Dysplasia Common Mutations

A
  • GNAS1
  • G-protein mutations
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37
Q

Pathology?

A

Fibrous Dysplasia

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38
Q

Pathology?

A

Fibrous Dysplasia

39
Q

Cartilage Forming Lesions Examples

5 Listed

A
40
Q

Osteochondroma General Features

A
41
Q

Osteochondroma Etiology

A
42
Q

Osteochondroma Radiological Features

A
43
Q

Osteochondroma Histological Features

A
44
Q

Pathology?

A

Osteochondroma

45
Q

Pathology?

A

Osteochondroma

46
Q

Osteochondroma common mutations

A

EXT 1 and EXT2

47
Q

Enchondroma General Features

A
48
Q

Enchondroma Radiological Features

A
49
Q

Enchondroma Etiology & mutations

A
50
Q

Pathology?

A
51
Q

Enchondromatosis General Features

A
52
Q

Pathology?

A
53
Q

Chondrosarcoma General Features

A
54
Q

Chondrosarcoma Radiological Features

A
55
Q

Pathology?

A
56
Q

Chondrosarcoma Etiology, classification and mutations

A
57
Q

Chondrosarcoma Histological Features

A
58
Q

Pathology?

A

Chondrosarcoma

59
Q

Giant Cell (radiolucent) Tumors

3 listed

A
60
Q

Giant Cell Tumor of Bone General Features

A
61
Q

Giant Cell Tumor of Bone Histological Features & Mutation

A
62
Q

Pathology?

A

Giant Cell Tumor of Bone

63
Q

Aneurysmal Bone Cyst Description

A
64
Q

Aneurysmal Bone Cyst General Features

A
65
Q

Aneurysmal Bone Cyst Radiological Features

A
66
Q

Aneurysmal Bone Cyst Histological Features

A
67
Q

Pathology?

A
68
Q

Pathology?

A
69
Q

Pathology?

A
70
Q

Non-ossifying Fibroma General Features

A
71
Q

Non-ossifying Fibroma Radiological Features

A
72
Q

Non-ossifying Fibroma Histological Features

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73
Q

Pathology?

A
74
Q

Pathology?

A
75
Q

Distribution of Giant Cells

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76
Q

Ewing’s Sarcoma General Features

A
77
Q

Ewing’s Sarcoma Radiological Features

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78
Q

Ewing’s Sarcoma Histological Features

A
79
Q

Pathology?

A
80
Q

Metastatic Tumors to Bone

A
81
Q

Metastatic Tumors of Bone General Features

A
82
Q

Metastatic Tumors of Bone Other Things to Consider

A
83
Q

Fibrous Dysplasia related syndromes

A

Mazabraud Syndrome

McCune-Albright Syndrome

84
Q

Fibrous Dysplasia Mutations

A

GNAS-1 (G-protein mutations)

85
Q

Mazabraud Syndrome

A
  • Fibrous Dysplasia
  • Soft Tissue Myxoma
86
Q

McCune-Albright Syndrome

A
  • Fibrous Dysplasia
  • Cafe-au-lait skin pigmentations
  • Endocrine abnormalities
87
Q

Osteochondroma Mutations

A

EXT gene Mutations

88
Q

Pedunculated or Sessile Definition

A
89
Q

Ollier and Malfucci Disease

A

Maffucci syndrome is distinguished from a similar disorder that involves enchondromas (Ollier disease) by the presence of red or purplish growths in the skin

90
Q

Enchondroma Mutations

A

IDH! and IDH2

91
Q

Chondrosarcoma Mutations

A

IDH1 and IDH2 like Enchondroma

92
Q

Giant Cell Tumor Mutations

A

H3F3A Mutations

93
Q

Aneurysmal Bone Cyst Average Age

A

< 20 years of age in the skeletally immature

94
Q

Ewing’s Sarcoma Mutation

A

t(11;22) EWSR1-FLI1 fusion gene

MSCT (30 decks)

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