MOLECULAR DISPERSIONS Flashcards
dispersed phase completely dissolved – homogenuous molecular dispersion
TRUE SOLUTION
particle size of true solution
below 1nm
can’t scatter light and can’t be visualize using the microscope
TRUE SOLUTION
Multi-component – mixture of two or more substances, forming a single phase
TRUE SOLUTION
2 components
DISPERSED PHASE
DISPERSION MEDIUM
internal phase
DISPERSED PHASE
external phase
DISPERSION MEDIUM
- The diameter of particles is roughly 1 to 500 nm
- Falls between true solution and coarse dispersion
COLLOIDAL SOLUTION
- The diameter of particles is greater than 500 nm
- 2 or more phases
SUPENSION & EMULSIONS
Components/Constituents of true solutions
solute
solvent
lesser amount (solid)
SOLUTE
greater amount (liquid, water)
SOLVENT
solute + solvent
SOLUTION
used to indicate a multi-compartment system in which one or more solute is dissolved in a solvent.
SOLUTION
Drug properties in solution are important because a drug solution is dispersed in
MOLECULAR LEVEL
essential for a drug to exert its chemical, biochemical, and pharmacological effects.
DRUG PROPERTIES
The quantity of a drug that indicates the strength of its chemical and pharmacological activities is not the weight of the drug, but rather the number of molecules or ions available for the drug action.
SOLUTE
used to describe drug’s pharmacologic action
CONCENTRATION / MOLECULAR EXPRESSIONS
Solutes are expressed in
moles, osmoles, meqwt
- A substance (an acid, base, or salt) that is in an aqueous solution ionizes to positive ions (cations) and negative ions (anions)
- Has greater freezing point depression and boiling point elevation than do non-electrolytes of same concentration
ELECTROLYTES
- Substances that do not ionize when dissolve in water and therefore do not conduct electricity through the solution.
- Lesser greater freezing point depression and boiling point elevation
NON-ELECTROLYTES
almost all drugs are
organic compounds
- Substances that completely ionize in water
- Degree of ionization is pH independent
- ionic compounds
STRONG ELECTROLYTES
- Substances that partially ionize in water
- Degree of ionization is pH dependent
- organic compounds w/ EN element
WEAK ELECTROLYTES
a prescription medicine used to treat the symptoms of low blood pressure during anesthesia (hypotension)
EPHEDRINE
A solution composed of only two substances (a solvent & a solute)
BINARY SOLUTION
physical properties of systems that depend on the quantity of the matter in the system
EXTENSIVE PROPERTIES
physical properties that are independent of the amount of the substances in the system
INTENSIVE PROPERTIES
depend mainly on the number of particles in a solution
COLLIGATIVE PROPERTIES
depend on the total contribution of the atoms in the molecule or on the sum of the properties of the constituents in a solution
ADDITIVE PROPERTIES
depend on the arrangement and a lesser extent on the number and kind of atoms withinn a molecule
CONSTITUTIVE PROPERTIES
can be expressed either in terms of the quantity of solute in a definite volume of solution or as the quantity of solute in a definite mass of solvent or solution
CONCENTRATION OF A SOLUTION
expressions commonly used in analytical work
MOLARITY & NORMALITY
moles of solute in 1L of solution
MOLARITY
gram equivalent weights of solute in 1L solution
NORMALITY
moles of solute in 1000g of solvent
MOLALITY
grams of solute in 100g of solution
%w/w
milliliters of solute in 100mL of solution
%v/w
grams of solute in 100mL of solution
%w/v