Module 9 Part 3 (Dissociation Curve) Flashcards
When you are exercising (or septic in the MICU w/ lactic acidosis) is there a shift to the right or left in the oxyhemoglobin dissociation curve?
Shift to the right
In a shift to the right, is there an increased or decreased affinity for O2? (in respect to bonding to Hgb)
Decreased affinity
In a shift to the right, are the tissues consuming more O2?
Yep
In a shift to the right, what happens to temp?
Temp increases (thermal energy required to break Hgb and O2 bonds -> decreasing affinity)
In a shift to the right, what happens to CO2 in the blood?
Increases (More O2 is consumed by the tissues, therefore more CO2 is released from the tissues into the blood stream. Everything is working harder!)
In a shift to the right, what happens to blood pH?
Decreases (more H+ and CO2 released into the blood from tissues)
In a shift to the right, what happens to 2,3-BPG levels in the blood?
Increases (2,3-BPG is a byproduct in glycolysis reactions during carbohydrate metabolism. When these reactions are accelerated and more frequent (d/t increased metabolism during sepsis or exercise) excess 2,3-BPG is produced and gets deposited in the blood along with the H+ and CO2 molecules)
What is the official name describing Hgb’s decreased affinity for bonding with O2?
The Bohr effect
In a shift to the left, is there an increased or decreased affinity for O2? (in respect to bonding to Hgb)
Increased affinity
In a shift to the left, are the tissues consuming more O2?
Nope
In a shift to the left, what happens to temp?
Decreases
In a shift to the left, what happens to CO2 in the blood?
Decreases (less O2 consumption by tissues, therefore less CO2 output in the blood. Less metabolism also = less CO2 byproducts produced)
In a shift to the left, what happens to blood pH?
Increases (less H+ & CO2 deposited by tissues in blood)
In a shift to the left, what happens to 2,3-BPG levels in the blood?
Decrease
