Module 4 drugs Flashcards
(222 cards)
decongestants
epinepherine-like drugs, alpha agonists; vasocontrictors used to reduce upper airway congestion; often combined with antihistamines in many cold remedies
Can be taken as spray or orally (but locally is better b/c you avoid systemic side e’s for the most part)
NeoSynephrine
phenylephrine; nasal spray decongestant (only lasts about 4 hours)
Phenylephrine is most oral decongestant nowadays, even though oral form is no better than placebo (yet still produces sympathomimetic side e’s)
Afrin
oxymetazoline; alpha agonist, very good decongestant that lasts about 12 hours
Sudafed
pseudoephedrine (originally, but now it is usually not); good decongestant, but abused so heavily it is only behind counter in pharmacies as OTC
*does increase BP though so bad for those with HTN or CHF, so best to use nasally
antihistamines
H1 rc blockers in cells of ENT so histamine cannot bind to them when mast cells degranulate in response to allergens
They are found in many cold remedies despite no proven cold benefits
1st gen antihistamines
older, inexpensive antihistamines (H1 rc blockers) that cause drowsiness (now this effect is used in OTC sleep aids)
*some are also used for their anti-nausea effects from anticholinergic properties
Benadryl
diphenhydramine; 1st gen antihistamine that works quickly; also used for antinausea effects from parasympatholytic activity
Phenegran
promethazine; a phenothiazine that works like a 1st gen antihistamine; also used for antinausea effects b/c of parasympatholytic effects
doxylamine
1st gen antihistamine; found in many cold and cough medicines meant to induce sleepiness (like Nyquil)
*shorter 1/2 life than Benadryl
Chlor-Trimeton
chlorpheniramine; 1st gen antihistamine that works very quickly
Claritin
loratidine; only early 2nd gen antihistamine still on market
2nd gen antihistamines
better tolerated than 1st gen and are not sedating; also work better at treating hay fever
*should always be used prophylactically
Allegra
fexofenadine; newer 2nd gen antihistamine
Zyrtec
cetirizine; newer 2nd gen antihistamine
LTAs
leukotriene rc antagonists; treat asthma and severe hay fever not responding to antihistamine therapy; block eicosanoids produced in AA pathway from lipoxegenase which are inflammatory mediators and cause bronchoconstriction
- hard to get insurance to cover; must prove much better relief than with antihistamines
- all -leukast
Singulair
montelukast; leukotriene rc blocker; oral tablet 1/day
Accolate
zafirlukast; leukotriene rc blocker
Ultair
pranlukast; leukotriene rc blocker that is in late stage trials in US
mast cell stabilizers
coat mast cells and prevent release of proinflammatory granules; inert drugs
Used for asthma and allergies
*only effective prophylaxis b/c it must be used before mast cells degranulate
*also used now for people who get ulcers from allergies
NasalCrom
cromolyn sodium; mast cell stabilizer prototype that is still used commonly
Used nasally, but also as solution that can be nebulized for lungs/airway
corticosteroids
Used in upper airways to treat resistant inflammation (like in allergic rhinitis); inhibit AA cascade
Not actual bronchodilators, so don’t use in acute, but dramatically reduce inflammation in 4-6 hours (good for maintenance asthma therapy)
Terrible long-term side e’s; better to use locally to avoid side e’s
All require Rx
Flonase nasal spray
fluticasone; corticosteroid used in upper airway
Nasacort nasal spray
triamcinolone; corticosteroid for upper airway
Orabase
triamcinolone; corticosteroid applied to canker sores in mouth, although there is no proven benefit