Module 12 Exam 2 Flashcards
What is diabetes mellius
a group of metabolic diseases characterized by hyperglycemia
what does hyperglycemia result from
and insulin deficiency, resistance to insulin or both
What is chronic hyperglycemia associated with
long term damage, dysfunction, and failure of numerous organs, especially the eyes, kidneys, nerves heart, and blood vessels
what becomes more prevalent as the population ages and obesity increases
diabetes
What is insulin
a hormone produced by the beta cells in the pancreas
what does insulin effect
it directly or indirectly effects every organ in the body
what does insulin enable
glucose transport into cells to use as energy
what are the main functions of insulin
- facilitates glucose uptake from blood into tissues
- speeds oxidation of glucose within cells for energy
- speeds conversion of glucose to glycogen to store in the muscles to prevent it converting back to glucose
- conversion of glucose to fat in adipose tissue
what are normal blood glucose levels in healthy individuals
60-150 mg/dl
what happens with the increased glucose in the blood in type 1 diabetes
it spills over into the urine, causes excretion of large amts of urine, causes water and electrolyte loss, which signals thirst in the brain
What may cells in Type 1 diabetes starving for glucose cause the patient to do
increase food intake, but weight loss may still occur
Without glucose for energy in Type 1 was does the body do for energy
metabolizes fat for energy
what does the metabolism of fat end in
harmful ketones that accumulate in the blood
what are ketones
when in large quantity body cant handle and it causes metabolic acidosis
what can metabolic acidosis lead to
a diabetic coma
does the insulin production and secretion by the pancreas remain at normal levels in type 2 diabetes
yes
what happens in type 2 diabetes
-insulin receptors develop defects and glucose cant be transmitted to the cell
what level increases as the insulin resistance of the cells increase
blood glucose levels
What is hypoglycemia/insulin shock
-too much insulin which lowers level of blood glucose
what is the more common emergency likely to occur in the dental setting, hyper or hypo
hypoglycemia
what is hyperglycemic reaction/ diabetic coma (ketoacidosis)
too little insulin, increased levels of blood glucose
What is type 1 diabetes
-absolute insulin deficency resulting from the destruction of the insulin-producing beta cells in the pancreas
When does type 1 diabetes usually arise
childhood or puberty
what are former names of type 1 diabetes
-insulin dependent diabetes mellitus, juvenile diabetes, juvenile onset, ketosis-prone diabetes, brittle diabetes
what is type 2 diabetes
pancreatic insulin secretion may be low, normal, or even higher than normal but the patient exhibits an insulin resistance that impairs the use of insulin
what is gestational diabetes mellitus
any degree of glucose intolerance with onset or first recognition during pregnancy
what is gestational diabetes related to
genetics, obesity, hormones
when is gestational diabetes diagnosis reclassified
6 weeks after pregnancy ends
what has lessened the danger of gestational diabetes for the mother
insulin adjustment, carefully supervised prenatal care, improved obstetrics
What are characteristics of the pregnancy and baby in a mother with gestational diabetes
- larger infant
- premature births more freq
- congential malformations, perinatal death
- tendency to develop type 2 diabetes later in life
What do other types of diabetes result from
-genetic defects, diseases, endocrinopathies, surgery, drugs, malnutrition, infections, injury
what are some genetic defects that cause diabetes
- genetic defects of the beta cell, or insulin action