Missed questions Flashcards
Drugs that cause folic acid deficiency
Phenytoin
Trimethoprim (dihydrofolate reductase)
Methotrexate (DHFR) leucovorin rescue
Pruritis after shower, dizziness, headache, HTN, facial plethora, hypercellular BM
PCV
- Primary = LOW EPO, JAK2 mutation
- Secondary = Normal/high EPO, hypoxemia, renal tumor, hepatic tumor, testosterone replacement
- can precipitate GOUT attack
Immune-mediated drug reaction by captopril
Membranous GN
35 weeks gestation, HTN, dec urinary output, thrombocytopenia
Preeclampsia w/ severe features (pul edema, LFTs, SBP >160, inc Cr) –> hydralazine or labetalol then mag sulfate
93 y/o vaginal bleeding, odor, mass, no mets
SCC –> resect 2cm or poor surgical candidate
Combination chemotherapy stage III, IV
High non-response rate, use only hospital-based patients, loss of study patients type of bias
Selection bias
Improves mortality in CHF
ACE, BBs, spironolactone
Exudative pleural effusions
Protein >0.5, LDH >0.6 that of normal
Infection, auto-immune, neoplasm
INC CAPILLARY PERMEABILITY
Low TSH, high T4, T3, no signs of Grave disease, low RAIU
Facticious or exogenous thyrotoxicosis = LOW serum thyroglobulin
Low TSH, high T4, T3, no signs of Grave disease, high RAIU
Diffuse = Grave Nodular = toxic adenoma or mulitnodular goiter
Tachycardia with buried P-waves, chest pain, diaphoresis, normal BP, hx anxiety, dizziness
SVT = Adenosine
Bone pain, difficulty walking, cramps, pseudofractures
Osteomalacia = INC PTH, alk phos + LOW Ca, phos, 25D-OH
- malabs, chronic liver, kidney, intestinal bypass, celiac
- # 1 = vit d deficiency
Fever, back pain w/ local tenderness, recent UTI, NO leukocytosis, INC ESR/CRP, normal x-rays
Osteomyelitis –> MRI –> CT guided aspiration
White edematous retina following retinal arterioles, curtain falling over eye
Retinal emboli –> carotid doppler
Painless loss of vision, boxcar segmentation, cherry fovea, pallor or hyperemic disc
CRAO
Mallory bodies and neutrophilic infiltrate on liver bx
Alcoholic hepatitis = completely reversible w/ etOH cessation
Regenerative nodules = cirrhosis = irreversible
Encapsulated yeast
Cryptococcus neoformans = amphotericin B + flucytosine –> fluconazole for 1 yr
Itraconazole does NOT cross BBB
DOC for Lyme disease < 8/yo
Amoxicillin or cefuroxime
HIV pt, pancytopenia, palatal ulcers, hepatosplenomegaly, intetstitial pneumonitis
Histoplasma
New DOE, swelling of head, neck, arms, plethora of face, no LE edema, ascities
SVC syndrome –> CXR for NHL or lung CA
DVT –> heparin therapy –> 6th day new right sided weakness, aphasia, 50,000 platelets, skin necrosis, normal CT, heart RRR, no fibrin split products
HIT type 2 (antibody platelet activation)
- –> binds PF4 –> IgG –> activates Fc receptor leading to platelet activation
- –> ARTERIAL or venous THROMBOSIS
HIV esophagitis work-up
- Candida –> oral fluconazole
- esophagoscopy + bx, cytology, culture w/o improvement
HSV = round/ovoid ulcers + perioral ulcers CMV = linear ulcers
Common findings in anorexic patients
- Osteoporosis
- Elevated cholesterol and carotene
- Prolonged QT
- Euthyroid sick syndrome
- HPA axis - amenorrhea, anovulation, dec estrogen
- HypoNa
- Small for gestational age baby, intellectual impairment, miscarriage, depression, hyperemesis, c/s
Southern US + tick bite + thrombocytopenia + leukopenia, fever, malaise, inc LFTs, inc LDH, intracytoplasmic morulae
Ehrlichiosis –> doxycycline
32 w/ hx seizures, migraines, bipolar –> slurred speech, very drowsy, unsteady gait, normal resp, normal pupils, no nystagmus
Benzo overdose
65 w/ PNA sx + very high WBC, 84% lymphocytes w/ smudge cells.”
CLL –> flow cytometry
RBCs 1-6hrs later fever, chills, malaise
Nonhemolytic transfusion rxn = leukoreduction (red HLA, CMV)
Anaphylaxis w/ PRBCs = IgA deficiency = wash cells 1st
Eczematous, itchy rash over nipple, no other hx of skin problems
Paget disease of breast = underlying adenocarcinoma
Truncus arteriosus, micrognathia, no thymus, cleft lip
DiGeorge = hypoCa
Thickening of pre-vertebral tissues, neck pain, fever next step
IV abx, IVFs & surgical drainage
Uncontrolled DM, weight loss, neuropathy, 3months of N/V, dec appetite
Gastroparesis —> gastric scintography
- Hepatitis uses reverse transcriptase
2. Hepatitis coats itself in LDL
- HBV
2. HCV –> IF-a
Infective endocarditis bugs
- dentition
- IVDU
- UTI
- HACEK group, strep viridan/sanguis
- SA, staph epi/CoagN
- Enterococcus faecalis
Tx of hypercalcemia
Asx = avoid thiazides, lithium, dehydration Sx = nothing immediate or see severe Severe/malignancy = NS + calcitonin short term --> zoledronic acid long term Granulomatous = steroids to reduce VitD
Shoulder dystocia –> extended forearm, MCP, flexed PIP/DIPs, horner syndrome, ABSENT grasp reflex
C8, T1 injury = Klumpe’s palsy
—> massage and gentle PT
COPD w/ inhaled salmeterol, duonebs, theophylline –> recent URI w/ cipro –> HA, N/V, insomnia, multifocal atrial tachycardia
Theophylline toxicity –> check serum level
1st febrile UTI <24mo work-up
7-14d abx
renal and bladder US (also if recurrent or do not respond to abx)
Physiology of CHF w/ peripheral edema
Dec circulating BV –> inc angiotensin & aldosterone release –> constrict renal arterioles & reabsorb salt and water –> increased BV which exacerbates CHF further
Muscle aches and pains, HIGHLY ELEVATED CPK, mild elevation in LFTs
Stop statins - muscle injury –> rhabdomyolysis & RF
Hazard ratio >1
More likely to occur in tx group
1 = no difference
<1 = more likely in control
Teen, gradual difficulty walking, speech problems, falling down, scoliosis, hammer toes
Freidrich ataxia
- Cardiomyopathy –> death
Gestational bleeding
- HTN, contractions
- Painless, C/S, smoking, multiple gestation
- Painless bleeding + rapidly deteriorating fetal tones
- Abruption
- Previa
- Vasa previa
Young obese female on OCPs, steroids, Vit A, tetracycline, has dull HA for 3 weeks, papilledema
Benign intracranial HTN –> blindness
1. weight reduction, acetazolamide then shunt and optic nerve fenestration
A.A. woman with pelvic heaviness + constipation + urinary frequency and posterior uterine mass and enlargement and HEAVY, prolonged periods WITHOUT spotting
Uterine leiomyoma/fibroid
Hypotension, bradycardia, cold, clammy, AV block - unresponsive to IVFs and atropine
Glucagon
- BB overdose (w/ wheezing), CCBs
A.A. male w/ fam hx of fatal blood disorder, recurrent otitis media, HAV –> nocturia, frequency
Hyposthenuria - sickling in vasa recta impairs water re-absorption
HSM, anemia, thrombocytopenia, night sweats, HA, dizziness, visual problems, pain and numbness in extremities, IgM spike
Waldenstrom’s macroglobulinemia
- MM have IgG or IgA
- MGUS = Asx
Winter’s formula for acid-base compensation
PCO2 = 1.5 (HCO3-) + 8
Post- transplant fever, chills, sputum production + RLL consolidation + branching, beaded gram + rods
Nocardiosis (partially acid-fast) —> TMP-SMX
Anterior MI + muffled heart sounds, S3, bibasilar crackles and dyspnea next step
Flash pulmonary edema –> lasix –> dec preload, pulm capillary pressure
Avoid BBs in this setting
When can exposure odds ratio from a case-control study = relative risk?
Prevalence of disease is low
S/P CABG with ventricular rhythm narrow QRS irregular tachycardia, hypotensive
AFIB –> DC cardioversion
Failure to pass meconium, 1st step XR –> marked bowel dilation & r/o pneumoperitoneum next step
Contrast enema –> microcolon for CF –> Gastrografin enema
Central/above pons Facial nerve palsy vs. peripheral/below pons
Central = CL weakness + preserved forehead, eyebrow, eyelid function
Co-morbidities in Turner syndrome
Osteoporosis
Coarctation of aorta
Congenital lymphedema (non pitting), short 4th digit, nail dysplasia, horseshoe kidney
Young male anterior mediastinal mass + bHCG + AFP
NON-seminimatous germ cell tumor (AFP+)
Acyclovir + acute renal failure cause
Insoluble –> crystalluria –> renal tubular OBSTRUCTION
Mood disorder and paranoia, hallucinations –> mood improves but paranoia remains
Schizoaffective disorder
Tx OCD
SSRIs
When to hospitalize anorexic pt
Dehydration, hypoK, hypoPhos, bradycardia, severe weight loss —> refeeding syndrome w/ electrolyte abn, arrhythmia and heart failure
Tx in anorexia and bulimia
1st is nutritional and CBT
Buproprion is CI d/t SEIZURE
anorexia = olanzapine bulimia = SSRI
Dysparenunia, dysmenorrhea, DYSCHEZIA, cyclical pelvic pain, infertility, CMT
Endometriosis –> OCPs + NSAIDs
Unrelieved –> laparoscopy
Precursor to GB adenocarcinoma
Porcelain gallbladder
Cyanotic infant w/ LEFT axis deviation, no R waves in precordial leads, dec pulmonary markings, tall peaked P waves, LLSB holosystolic murmur
Tricuspid valve atresia
Conservative vs. laparoscopy in SBO
Laparoscopy
- tachycardia, leukocytosis, fever, acidosis, peritoneal signs
Inc QRS from 0.8 –> 0.13 with inc HR during stress test result of what drug?
Flecainide
- ventricular arrhythmia and SVTs like AFIB
- use-dependence block of Na channels
Post-partum patient, fever, chills, WBC 11,000, uterus firm, non-tender, bloody discharge with clots –> pale –> yellow/white next step
Reassurance
- lochia foul smelling = endometritis
- fever normal in first 24hrs or so
HL treated 20 years ago w/ chemo and radiation –> now circular mass on xray dx?
Secondary malignancy
- also breast, thyroid, bone, GI
Russian immigrant, fatigue, cough, fever, weight loss, upper lung lesion + hyperNa, hypoK, hypoglycemia, eosinophilia acid-base abnormality?
Normal anion gap metabolic acidosis d/t primary adrenal insufficiency
Mechanism of hypoxia in pt with AIDS, interstitial crackles
PCP –> Dec A-a oxygen gradient