Misc, nutritional, congenital and inherited skin disease Flashcards
What clinical signs and presenting complaints do dogs with juvenile cellulitis present with?
- ACUTE onset within 24-48hrs
- Symmetrical facial swelling
- Submandibular LN enlargement
- Non pruritic and non painful
- Papules, pustules and draining sinuses
- Seen in puppies 3 weeks to 3 months of age
What age of onset can dogs present with juvenile cellulitis?
ACUTE onset in puppies 3 weeks to 3 months of age
A 2 month old lab puppy is presenting for a fever, enlarged submandibular LN’s, and facial swelling with evidence of draining sinuses. The owner noted the puppy was acting completely normal yesterday. What is your top DDx and how would you confirm your diagnosis?
- Suspect puppy strangles / juvenile cellulitis
- Perform cytology to see macrophages and neuts in the ABSENCE of bacteria
- Could also do skin biopsy
What would you expect to see on a cytology sample from a puppy with juvenile cellulitis?
macrophages and neuts in the ABSENCE of bacteria
(sterile pyogranulomatous dermatitis, no infection)
Which dog breeds are predisposed to Zinc deficiency syndrome I?
Huskys and Malamutes (Arctic breeds)
What is the first line treatment for juvenile cellulitis?
Prednisone SID x 7 days
What is the pathophysiology behind Zinc deficiency syndrome 1?
- Genetic issue in malamutes and huskies resulting in the inability to absorb Zinc from GI tract
- Results in cutaneous, neuro, GI, and growth defects
What age of onset do dogs with Zinc deficiency 1 typically present with cutaneous lesions?
Between 1 and 3 years of age
What cutaneous lesions can be seen with Zinc deficiency 1?
- Symmetrical crusting, scaling, alopecia, lichenification
- Seen at mucocutaneous junctions (eyes, ears mouth), genitals, and pressure points (elbows)
What is the pathophysiology behind Zinc deficiency syndrome II?
- Due to a high cereal based diet and plant based diet high in phytate
- Similar lesions to Zinc def I
Zinc def II is a DIET issue, Zinc def I is a GENETIC issue
How can zinc deficiency be diagnosed?
Histo showing parakeratosis (nucleated keratinocytes)
What causes superficial necrolytic dermatitis in DOGS?
- Hepatic neoplasia, cirrhosis, hepatitis
- Dogs on phenobarbital
(associated with pancreatic cancer in CATS)
What history and clinical signs are observed in dogs with superficial necrolytic dermatitis?
- Non pruritic
- Seen in older dogs
- Seen in Westies, Cockers, Shetland sheepdogs, and Scottish terriers
- Hyperkeratosis of foot pads
- Fissuring of foot pads
- Will also have systemic CS bc of underlying liver disease
How can superficial necrolytic dermatitis in dogs be diagnosed?
- Skin Biopsy/histo to see RED WHITE AND BLUE (hepatocutaneous syndrome)
- Diagnostic imaging to ID liver pathology
What is the pathogenesis behind sebaceous adenitis in dogs?
Immune mediated destruction of sebaceous glands resulting in lack of sebum
