MIDTERM II - TOPIC 26-28

Question 1

26: ANTIHISTAMINES:

1. Used for? Efficacy?
2. In severe histamine release, what reaction do we see?
   
   1. Example when we see this reaction
3. Severity of the reaction?
4. Treatment for this reaction?
5. What happens during the reaction?
6. Antihistamines combined whit?

Answer 1

• These are the oldest drugs used as an anti-allergic however, their efficacy is not that high.
• In severe histamine release where we can see anaphylactic reactions and anaphylactic shock for example in
  
  • vaccines,
  • penicillins,
  • insect bites or even
  • when we administer LOKIVETMAB to a cat or horse etc.
• Anaphylactic reactions can be life-threatening and in these cases, antihistamines can be used as a treatment but they must be combined with other, more effective, drugs.
• In anaphylactic reactions, vascular permeability increases i.e. epiglottis oedema can occur, leading to suffocation.
• Angioedema (tumors and nodules on the head) can occur like in the picture below of the dog.
• This can be followed by a vaccination reaction.
• In extreme cases, severe vasodilation can lead to shock i.e. anaphylaxis can be life-threatening in which we treat it with antihistamines combined with
  
  • adrenaline,
  • glucocorticoids etc.

Question 2

26: ANTIHISTAMINES:

1. Other allergy mediated diseases?
2. Antihistamines and efficacy, how many % active in the dog?
3. Due to atopic dermatitis, it is mediated by histamine and?
4. Safety and economic point of view

Answer 2

• Allergy mediated diseases e.g.
  
  • atopic dermatitis,
  • cutaneous food adverse reactions (food allergy) or
  • flea allergy dermatitis (FAD),
    
    • antihistamines have a low efficacy where they are active in only 20% of the dog.
    • This is due to the fact that the majority of cases of atopic dermatitis are not only mediated by histamine but by other cytokines e.g. interleukins etc.
    • They are safe and cheap and this is why they are tried.

Question 3

26: ANTIHISTAMINES:

1. When can we use antihistamines prior to?
2. Which substance?
3. Before the administration of which drug (causes serious histamin release)

Answer 3

1. Used before surgery as
2. ACEPROMAZINE e.g.
3. before morphine administration as we have learned that morphine causes a serious histamine release.

Question 4

26: ANTIHISTAMINES:

Mechanism of action:

1. ​Acts like which inhibitors?
   
   1. ​Not …..?
   2. Do not bind to which receptor to block histamine binding
   3. Known as??
2. ​Histamine receptor has 2 stages?
3. If histamin is present - Which reaction?
   
   1. ​Side effects
4. ​In case of drug administration what will favor which reaction? What will happen due to it?

Answer 4

Mechanism of action:

• These, like JAK inhibitors,
  
  • are not antagonists i.e.
  • they do not bind to the histamine receptor to block histamine binding.
  • Instead, they are known as inverse agonists.
• The histamine receptor has an active state (GTP present) and an inactive state (GDP present) that are within a unique balance with each other.
• If histamine is present e.g. in an anaphylactic reaction, the active state will be initiated and side effects of
  
  • vasodilation,
  • epiglottis oedema,
  • nodules etc. can be seen.
• In the case of drug administration, these inverse agonists (antihistamines) will favor the left reaction and inactive the action and the side effects will be inhibited.

Question 5

26: ANTIHISTAMINES:

Usage:

Answer 5

Usage:

• These are used in allergic reactions of course.
• In asthma or RAO,
  
  • their use is controversial where their activity is not high enough and they usually do not work.
• They are used in anaphylactic reactions in combination with
  
  • adrenaline and
  • glucocorticoids (antihistamines will not be enough).
• In the case of atopic dermatitis etc. the chance of success with antihistamines is approx. 20-25%.

Question 6

26: ANTIHISTAMINES

Other classes of drugs used:

Answer 6

• These drugs have a very unique place in the veterinary field.
• They are put into two generations.

1. Ist generation: These cross the blood-brain barrier very easily, this is why their side effects include
   
   1. sedation,
   2. uncoordinated movement,
   3. sleepiness,
   4. ataxia etc. i.e. CNS side effects
2. 2nd generation: These drugs do NOT cross the blood-brain barrier as well and this is why they cause sedation much less frequently when administered. Most of the human drugs are 2nd generation

Question 7

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Answer 7

• Ethylenediamines:
  
  • CHLOROPYRAMINE,
  • CHLORPHENIRAMINE
• Ethanolamines:
  
  • DIPHENHYDRAMINE,
  • DIMENHYDRINATE.
    
    • ​These two drugs are frequently used for vaccine allergy i.e. if you expect vaccine allergy, which is primarily seen in small dogs >10 kg.
    • This can occur in cases when an owner tells you that when their dog was previously vaccinated, they suffered an allergic reaction.
    • They are given orally, half an hour before administering the vaccination.
• Phenothiazines:
  
  • PROMETHAZINE,
  • ACEPROMAZINE
• Piperazines:
  
  • ​HYDROXYZINE.
  • This drug has the best activity in atopic dermatitis.
  • This was used before we had LOKIVETMAB.
  • The drug worked however, the action is slower than lokivetmab.
  • It is very safe but its efficacy is not as high as lokivetmab.
• Other:
  
  • DIMETINDEN,
  • CYPROHEPTADINE.
    
    • Used as an appetite stimulant
    • Feline asthma.

Question 8

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Ethylenediamines:

Answer 8

Ethylenediamines:

1. CHLOROPYRAMINE,
2. CHLORPHENIRAMINE

Question 9

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Ethanolamines:

Answer 9

Ethanolamines:

1. DIPHENHYDRAMINE,
2. DIMENHYDRINATE.

• ​These two drugs are frequently used for vaccine allergy i.e.
  
  • if you expect vaccine allergy, which is primarily seen in small dogs >10 kg.
• This can occur in cases when an owner tells you that when their dog was previously vaccinated, they suffered an allergic reaction.

They are given orally, half an hour before administering the vaccination.

Question 10

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Phenothiazines:

Answer 10

Phenothiazines:

1. PROMETHAZINE,
2. ACEPROMAZINE

Question 11

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Piperazines:

Answer 11

Piperazines:

• HYDROXYZINE.
  
  • This drug has the best activity in atopic dermatitis.
  • This was used before we had LOKIVETMAB.
  • The drug worked however, the action is slower than lokivetmab.
  • It is very safe but its efficacy is not as high as lokivetmab.

.

Question 12

26: ANTIHISTAMINES

Other classes of drugs used:

Ist generation:

Other:

Answer 12

Other:

1. DIMETINDEN,
2. CYPROHEPTADINE.
   
   1. Cyproheptadine is also used as an appetite stimulant
   2. Used in cases of feline asthma

Question 13

26: ANTIHISTAMINES

Other classes of drugs used:

2nd generation:

Answer 13

• Most of the human drugs are 2nd generation e.g.
  
  • LORATADINE,
  • CETIRIZINE,
  • LEVOCETIRIZINE,
  • CLARITINE.
• These are primarily used in humans however, they can also be used in dogs as trial and error drugs.
• Some can react well while others may not react at all.

Question 14

26: ANTIHISTAMINES

Pharmacokinetics:

1. Absorbtion
2. Dirstribution
3. Blood brain barrier
4. Metablolized
5. CYP-450

Answer 14

Pharmacokinetics:

• These drugs have good oral absorption however, it can be
• Slow with the maximum plasma concentration (Cmax)
  
  • being 2-3 hours.
• There is a difference in distribution between the 1st and 2nd generation drugs as they do not cross the blood-brain barrier with the same efficiency.
• This is because the 2nd generation is in an ionized form in the blood which
  
  • hinders its transport through the membranes.
  • They are also extensively albumin-bound.
• ​These two factors reduce the blood-brain barrier penetration.
• Metabolized in the liver and they are cytochrome (CYP-450) inducers i.e.
  
  • they affect (mainly reduce) other drug’s activity as they
  • increase cytochrome enzymes
  • which will help their metabolism.
    
    • This is one reason why they are not used.

Question 15

26: ANTIHISTAMINES

Side effects:

Answer 15

Side effects:

• They are very safe drugs.
• They can cause CNS depression (sedation)
• Cardiac toxicity
  
  • Primarily associated with 1st generation drugs and in humans
    
    • ​resulting in a prolonged QT interval in the ECG
  • Fortunately, this is not so frequent in animals.
• These drugs can be appetite suppressants (primarily in 1st generation drugs and in humans)
• Exception of CYPROHEPTADINE = Appetite stimulant.
• These are very safe but have low efficacy.

All in all, the best drugs to use would be

1. OCLACITINIB,
2. LOKIVETMAB or
3. CYCLOSPORIN.

Question 16

26: ANTIHISTAMINES

PHARMACOLOGY OF IMMUNOSUPPRESSION:

Answer 16

• When we apply glucocorticoids in higher doses,
  
  • Immunosuppressive effect.
• Other immunosuppressant agents include
  
  • antimetabolites,
  • alkylating agents
  • cytokine gene expression inhibitors.

Question 17

26: ANTIHISTAMINES

Immunosuppression indications:

Answer 17

Immunosuppression indications:

1. Autoimmune diseases:
2. H**ypersensitivity diseases:
3. Transplantation:

Question 18

26: ANTIHISTAMINES

Immunosuppression indications:

Autoimmune diseases: ​

Answer 18

Autoimmune diseases:

• These affect the mucous membrane and the skin.
• LUPUS, pemphigus complex
  
  • Reaction against keratinocytes i.e.
    
    • Breakdown of intracellular desmosomal bridges
    • Release of rounded keratinocytes
• IHA (immune haemolytic anaemia)
• KCS (keratoconjunctivitis sicca) - dry eye disease

Question 19

26: ANTIHISTAMINES

Immunosuppression indications:

Hypersensitivity diseases:

Answer 19

Hypersensitivity diseases:

• Atopic dermatitis
• Asthma
• IBD (inflammatory bowel diseases)

Question 20

26: ANTIHISTAMINES

Immunosuppression indications:

Transplantation:

Answer 20

Transplantation:

In order to avoid transplantation, immunosuppressant agents should be applied.

Question 21

26: ANTIHISTAMINES

Immunosuppression indications:

1. What does the picture show
2. What to do, 1st step?
3. If not enough fluid?
4. What should you apply?
5. Name the drug(s)?

Answer 21

• KCS with damage to the cornea.
• An ulcer can form in the cornea
• First stage = Perform the Schirmer test
  
  • Tell you whether or not there is enough tear fluid on the eye.
• If there is not enough, we would suspect the presence of KCS.
• You can apply cholinergic parasympathomimetics to the eye such as

1. PILOCARPINE but this is only symptomatic treatment. For better results, you can use
2. CYCLOSPORINE or
3. PIMECROLIMUS.

Immunosuppression can alleviate KCS.

Question 22

26: ANTIHISTAMINES

Drugs:

In general + antimetabolites

Answer 22

Drugs:

We can sometimes combine these drugs e.g.

1. CYCLOSPORINE can be combined with PREDNISOLONE which is a glucocorticoid.
   * This combination can have a beneficial effect if you would like to treat auto-immune disorders.

Antimetabolites:

• These block enzymes irreversibly
• Inhibit or cause damage to DNA.
• This means that they can be used to treat cancer as well as an antineoplastic agent.

Question 23

26: ANTIHISTAMINES

Drugs:

Answer 23

1. Purine-analogues:
2. Pyrimidine-analogues: LEFLUNOMIDE.
3. Folic acid antagonists: METHOTREXATE.
4. Alkylating agents:
5. Glucocorticoids:
6. Cytokine gene expression inhibitors:

Question 24

26: ANTIHISTAMINES

Drugs:

1. Purine-analogues:

1. AZATHIOPRINE
2. Integrates into? What will it do?
3. Used to treat?
4. Its antineoplastic has a significant effect on? Causing?
5. Sideeffects?
6. Prodrug?
7. Sensitivity and species?
8. Release?
9. Administration
10. Appication for which disease
11. How often administered
12. Contraindications

Answer 24

1. Purine-analogues:

1. AZATHIOPRINE,
2. MYCOPHENOLATE-MOFETIL.

• Azathioprine is a purine-analog that, once integrated into DNA, will
  
  • interfere with transcription and
  • reduces proliferation of the cells i.e.
  • Used to treat
    
    • immune-mediated hemolytic anaemia,
    • inflammatory bowel disease,
    • lupus etc.
  • This antineoplastic will have a significant effect on
    
    • cell division (will block cell division)
    • Block enzymes irreversibly i.e.
      
      • Cause inhibition or DNA damage
    • Several side effects - especially
      
      • vomiting,
      • diarrhea (GI disturbances because it has a significant effect on proliferative cells)
      • vomero suppression
      • Reduction in lymphocyte numbers (lymphocytopenia),
      • Anaemia
      • Thrombocytopenia.
  • Due to this DNA inhibition, it is also used to treat cancer.
  • Its prodrug is MERCAPTOPURINE and
    
    • cats are very sensitive to it.
  • The release is slow i.e.
    
    • takes up to 2 weeks to start working
    • but the effect is prolonged.
  • It is applied i/v but orally is also possible.
  • The application is for auto-immune diseases.
  • It is administered once a day for one week or every second day.
  • Please do NOT administer to pregnant or breeding animals as it has irreversible damage to gonads.

Question 25

26: ANTIHISTAMINES

Drugs:

1. Purine-analogues:

2. MYCOPHENOLATE-MOFETIL.

1. Mycophenolate-mofetil vs azathioprine?
2. Side effects
3. Usage in cats
4. Mechanism of drug
5. Censequence
6. Onset of action
7. Usage in combinations
8. Effect on which organ
9. If applied orally
10. In which condition is it especially better to use mycophenolate-mofentil instead of azathioprine?

Answer 25

1. Purine-analogues:

1. AZATHIOPRINE,
2. MYCOPHENOLATE-MOFETIL.

• The second purine-analog is mycophenolate mofetil.
• We prefer this drug to azathioprine as the
  
  • side effects are much rarer.
    
    • Liver toxicity,
    • vomero suppression
    • acute pancreatitis is not as significant in comparison.
• This drug is also safe to use routinely in cats.
• The mechanism of this drug is that it will inhibit inosine monophosphate dehydrogenase which is necessary to have purine.
  
  • The consequence of this is that there will be a reduction in T and B cell proliferation.
  • This is much safer.
• Gastrointestinal side effects are also rare.
• This has a faster onset of action also.
• It is regularly used in combination with steroid and CYCLOSPORINE.
• This drug will have an effect on bone marrow as there is de novo GTP synthesis i.e. salvage pathway.
  
  • Because of this, only the T and B-lymphocytes will be affected.
  • GI bone marrow will not be affected by the salvage pathways.
  • If this drug is applied orally, it will be hydrolyzed and converted to MYCOPHENOLIC ACID through the activation of plasma esterase i.e.
• If there is a liver insufficiency, this drug is better to use in comparison to azathioprine.

Question 26

26: ANTIHISTAMINES

Drugs:

2. Pyrimidine-analogues:

Answer 26

2. Pyrimidine-analogues:

LEFLUNOMIDE.

Question 27

26: ANTIHISTAMINES

Drugs:

3. Folic acid antagonists:

1. Blocks?
2. Result if we do not have enough tetrahydrofolic acid?
3. Administration?
4. Stimulates
5. Cells in resting phase
6. Applied against?
7. Side effects

Answer 27

3. Folic acid antagonists: METHOTREXATE.

• Methotrexate will block dihydrofolate reductase.
• The final result of this is that we do not have tetrahydrofolic acid i.e.
  
  • Nucleic acid and DNA synthesis will be blocked.
• It can be applied i/v, orally and i/m.
• It will stimulate the apoptosis of T-cells i.e.
  
  • this specifically influences T-cells.
• It has no effect on the cells in the resting phase.
• It can also be applied against LYMPHOMA in dogs and cats (antineoplastic agent).
• The side effects can be
  
  • hepatotoxicity,
  • pulmonary toxicity,
  • gastrointestinal side effects
  • Kidney side effects also i.e.
    
    • they are not as safe as mycophenolate mofetil. GI upset can occur.

Question 28

26: ANTIHISTAMINES

Drugs:

Best choice of drug in the case of autoimmune glomerulonephritis?

Answer 28

Mycophenolate mofetil is the best choice of drug in the case of autoimmune glomerulonephritis, accompanied by protein (mainly albumin) loss.

It is also important as it is the main drug of these that can be applied orally.

Question 29

26: ANTIHISTAMINES

Drugs:

1. Alkylating agents:
2. Influence which cells
3. Against which disease
4. Cause what to the DNA
5. Drugs

Answer 29

Alkylating agents:

• These will influence lymphocytes i.e.
  
  • fight against lymphoma, which is a specific type of cancer.
• These cause cross-linking of DNA and break DNA strands i.e.
  
  • Interfere with DNA replication and RNA transcription.

1. CYCLOPHOSPHAMIDE,
2. CHLORAMBUCIL.

Question 30

26: ANTIHISTAMINES

Drugs:

Alkylating agents:

1. ​CYCLOPHOSPHAMIDE and
2. CHLORAMBUCIL

​1. CYCLOPHOSPHAMIDE

1. Type of substance
2. Acrylating properties
3. Used to treat
4. Administration
5. Types of effects
6. Causes
7. Cats
8. Side effects
9. What to do if you observe ACROLEIN accumulation? Why?

​2. CHLORAMBUCIL

Answer 30

CYCLOPHOSPHAMIDE, ​CHLORAMBUCIL

• Cyclophosphamide is nitrogen mustard
• DNA alkylating properties i.e.
  
  • it will act mainly on proliferating cells.
• They can be used to treat lymphoma i.e.
  
  • also antineoplastic agents.
• It is applied either orally, i/v in form of infusion.
• They have GI side effects and bone marrow side effects.
• They will cause thrombocytopenia and lymphocytopenia
  
  • and this is why you must check the number of white blood cells.
  • If it is low, then you postpone the therapy.
• In the case of cats, if the white blood cell number is <2 giga/liter, you cannot start therapy.
• Other side effects include the whiskers falling out.
• Another side effect includes hemorrhagic cystitis due to the fact that the byproduct of this drug is ACROLEIN.
• This will be eliminated by urine, cats are not as sensitive to this than the dogs.
• If you observe the acrolein accumulation, you can administer FUROSEMIDE which is a diuretic i.e.
  
  • it will dilute the urine.
• These agents are mainly used orally and not only as autoimmune disorders, but also as antineoplastics.
• These are better to use in cats in comparison to dogs.

2. CHLORAMBUCIL will have the same mechanism of action and are applied orally.

Question 31

26: ANTIHISTAMINES

Drugs:

Glucocorticoids

1. Mechanism of action
2. Dose dependent or not
3. Name drug
4. From anti inflammatory drug to immunosuppressant?
5. Side effects
6. Interleikins

Answer 31

Glucocorticoids:

• These can have an
  
  • anti-inflammatory,
  • immunosuppressive,
  • anti-shock or
  • neuroprotective action
    
    • which is dose-dependent.
• As an anti-inflammatory, PREDNISOLONE can be used at 0.5-1 mg/kg but if you double or table this dose, it can be used a s an immunosuppressant also.
• The side effects include
  
  • delayed wound healing,
  • skin thinning,
  • alopecia,
  • polyurea,
  • polydipsia diuresis increase,
  • muscle atrophy (weakness),
  • gross retardation and
  • osteoporosis due to the fact that the calcium absorption is lowered.
• They also influence certain interleukins also and because they act against lymphocytes, in the case of lymphoma, their application is proven.

Question 32

26: ANTIHISTAMINES

Drugs:

Cytokine gene expression inhibitors:

Answer 32

Cytokine gene expression inhibitors:

These are calcineurin-inhibitors just like

1. CYCLOSPORINE,
2. TACROLIMUS,
3. PIMECROLIMUS.

Calcineurin is responsible for the dephosphorylation of NFAT (nuclear factor of activated T-cells). This means that in the nucleus, there will be the transcription of IL-2 which will produce these cells. If calcineurin is blocked, the T-cell number will be reduced.

Question 33

26: ANTIHISTAMINES

Drugs:

Cytokine gene expression inhibitors:

CYCLOSPORINE,

1. Interfere with
2. Inhibiting
3. Type of drug (tablet, suspension etc)
4. Bioavailability
5. Cat vs Dog dose
6. Therapeutic indications
7. Side effects
8. With or without food
9. In humans - side effect
10. Negligable side effect in dogs and cats
11. Side effect due to metabolic function
12. Cyclosporine is combined with?

Answer 33

Cyclosporine works primarily to:

• Interfere with T-lymphocyte activation
• Proliferation by inhibiting the production of
  
  • IL-2.
• It is administered orally,
• mainly emulsion and microemulsion because the bioavailability is 0.3.
• If it is not administered as a microemulsion, there will be a reduced bioavailability.
• In cats, we apply a higher dose (7 mg/kg) than in dogs (5 mg/kg).
• Local application is also possible.
• Therapeutic indication includes
  
  • Autoimmune diseases:
  • lupus,
  • pemphigus,
  • KCS (applied locally),
  • AIHA (autoimmune mediated hemolytic anaemia);
  • Atopic dermatitis
  • IBD (inflammatory bowel disease).
• The side effects include: vomiting emesis.
• It is better to apply with food but, the food will reduce the absorption of the drug i.e.
  
  • administer with a small amount of food only.
• In humans, there is liver toxicity and kidney problem
  
  • however, hepatotoxicity is negligible in dogs and cats.
• Alopecia can occur as well as gingival hyperplasia
  
  • due to the fact that the metabolic function of the gingival fibroblast will be influenced through IL-6 level change i.e.
    
    • immune response but it is still questionable.
• Cyclosporine is frequently combined with PREDNISOLONE i.e.
  
  • glucocorticoid cyclosporine combination is very frequent.

Question 34

26: ANTIHISTAMINES

Drugs:

Cytokine gene expression inhibitors:

TACROLIMUS

1. Tacrolimus vs Cyclosporine
2. Toxicity
3. Local application
4. Use it to treat
5. What happens if you apply it for approx 1 year
6. What is important when applied for topical use?

Answer 34

• Tacrolimus is 500 times more active than cyclosporine.
• The toxicity is increased and local application is possible.
• You can use it to treat:
  
  • atopic dermatitis,
  • lupus
  • pemphigus.
• If this drug is applied for approx. one year,
  
  • melanomas can develop, i.e. for humans,
• Important to wear rubber gloves when using this drug for topical application.

Question 35

26: ANTIHISTAMINES

Drugs:

Cytokine gene expression inhibitors:

PIMECROLIMUS

1. Used for
2. What to apply for KCS
3. Which is the best and why

Answer 35

• Pimecrolimus is used for:
  
  • atopic dermatitis
  • KCS.
• You can apply for KCS:
  
  • artificial tears,
  • parasympathomimetic
  • pimecrolimus/cyclosporine .
• The best to use is pimecrolimus as it is an immunosuppressant and KCS is an autoimmune disease

Question 36

27-28: PHARMACOLOGY OF THE RESPIRATORY TRACT:

These drugs will be able to treat what in which species?

Answer 36

These drugs will be able to treat

• Asthma in cats,
• RAO (recurrent airway obstruction) in horses
• Eosinophilic bronchitis in dogs.

Question 37

27-28: PHARMACOLOGY OF THE RESPIRATORY TRACT:

Pathophysiology of asthma:

1. Asthma is characterized by
2. This leads to
3. And causes
4. 2 types of bronchioconstrictions
5. Acute or chronic asthma
6. Asthma - type of disease
7. Aggregating factors regarding inflammatory aspect of asthma
8. RAO
9. COPD
10. COPD divided into 2 frequently ovrelaping diseases

Answer 37

• Asthma is a complex disease that is characterized by
  
  • airway inflammation,
    
    • which leads to airway hyperresponsiveness and in turn,
      
      • that causes symptomatic bronchoconstriction.
• There is a reversible part of bronchoconstriction that characterizes
  
  • The acute asthmatic reaction
• Chronic inflammation can induce airway remodeling
  
  • which causes it to become irreversible.
• Asthma is both an
  
  • obstructive lung disease
  • Inflammatory disease.
• The obstructive component is characterized by
  
  • bronchoconstriction.
• In terms of the inflammatory aspect of asthma, it will be marked by aggregating factors such as
  
  • airway oedema,
  • goblet-cell hyperplasia,
  • mucus secretion
  • infiltration by a wide variety of immune and inflammatory cells that release a number of associated cytokines.
• RAO: recurrent airway obstruction.
  
  • This is characterised as asthma in horses.
• COPD: Chronic obstructive pulmonary disease
  
  • ​Describes a spectrum of disorders that results in obstructive lung disease.
  • COPD is caused by an abnormal inflammatory response to an inhaled environmental insult.
  • COPD is divided into two frequently overlapping Diseases:

1. Pulmonary emphysema
   
   1. emphysema refers to alveolar enlargement caused by THE destruction of alveolar walls
2. Chronic bronchitis. ,
   
   1. Chronic bronchitis is a clinical diagnosis made on the basis of a chronic cough.

Question 38

27-28: PHARMACOLOGY OF THE RESPIRATORY TRACT:

Physiology of airway smooth muscle contraction::

1. What causes bronchodilation?
2. What causes bronchoconstriction?
3. Airway smooth muscle cells express which receptors?
4. The receptors are activated by?
5. In order to induce bronchodilation we administer?
6. In order to induce bronchoconstriction we administer?

Answer 38

• In the airways,
  
  • sympathetic (adrenergic) tone causes
    
    • bronchodilation and
  • parasympathetic (cholinergic) tone causes
    
    • bronchoconstriction.
• Airway smooth muscle cells express
  
  • β2-adrenergic receptors.
  • β2-adrenergic receptors are activated by
    
    • Adrenalin (beta-2-receptor agonist),
      
      • which is secreted by the adrenal medulla and causes
        
        • bronchodilation.
• Airway smooth muscle cells also express
  
  • muscarinic receptors,
    
    • especially the excitatory M3 subtype of muscarinic receptors.
• Upon stimulation via cholinergic drugs, these receptors
  
  • induce bronchoconstriction.
• All in all,
  
  • in order induce bronchodilation, we administer
    
    • parasympatholytics (anticholinergics).
    • sympathomimetics (beta-2-agonists) or
  • In order to induce bronchoconstriction,
    
    • we administer parasympathomimetics (cholinergics).

Question 39

27-28: PHARMACOLOGY OF THE RESPIRATORY TRACT:

Mast cells and leukotrienes:

1. Mast cell degranulation produces ?
2. Histamine released from the mast cells promotes?
3. Leading to?
4. Mast cells also release?
5. Essential to the pathophysiology of ASTHMA?
6. Because?
7. How to alleviate asthma causing bronchodilator?
8. An alternative way to inhibit the histamine release from the mast cells?
9. This will prevent?

Answer 39

• Acutely, mast-cell degranulation produces
  
  • bronchoconstriction and
  • airway inflammation.
• Histamine released by the mast cells promotes
  
  • capillary leakage,
    
    • leading to airway edema.
• Mast cells also release
  
  • leukotriene C4 (LTC4), which is
    
    • subsequently converted into LTD4 and LTE4.
  • These 3 leukotrienes, = cysteinyl leukotrienes, are central to the pathophysiology of asthma because they induce marked bronchoconstriction.
• If we administer leukotriene antagonists, we can cause
  
  • bronchodilation and alleviating asthma.
• We can also sterilize the mast cell in order to inhibit the histamine release and this will prevent
  
  • capillary leakage i.e. airway oedema.

Question 40

27-28: PHARMACOLOGY OF THE RESPIRATORY TRACT:

Drugs acting on the respiratory system:

Answer 40

1. Bronchodilators
2. Sympathomimetics:
   
   1. Long acting
   2. Short acting
3. Parasympatholytics:
4. Methylxanthine derivatives:
5. Respiratory antiinflammatory drugs
6. Inhalation glucocorticoids
7. Chromanes:
8. Leukotriene antagonists:
9. Antitussives:
10. Mucolytics:
11. Expectorants:

Question 41

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

1. Bronchodilators

1. Indication include?
2. Drugs can be?
3. Mechanism of action include?

Answer 41

• Their indications include
  
  • Anaphylaxis
  • Allergic bronchitis (Ca)
  • Asthma (Fe)
  • RAO (horse)
  • Pulmonary edema
  • Pneumonia
  • Pleural effusion
    
    • Excess fluid around the lung
  • Pneumothorax
    
    • When air escapes and gathers around the lung and adds pressure i.e.
      
      • collapsed lung.
  • Tracheal collapse
    
    • Weakened cartilage in a string of trachea
  • Hypoplasia.

These can be either:

1. Sympathomimetic (specific or non-specific),
2. Anticholinergic substances, or
3. XYLAZINE derivatives.

• Their mechanism of action includes either
  
  • Dilation via an elevation in cAMP levels, or
  • Block phosphodiesterase i.e.
    
    • indirectly block cAMP levels.
    • We can also block acetylcholine which is responsible for bronchoconstriction i.e.
      
      • this antagonism will cause bronchodilation.

Question 42

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

2. Sympathomimetics:

Answer 42

Sympathomimetics:

• These act mainly on the beta-2-receptors to convert ATP to cAMP via the adenylate cyclase enzyme which leads to bronchodilation.
• The adverse effects brought on by adrenergic agonists are minimized by inhalant delivery.
• They can be either non-specific or specific.
• The non-specific sympathomimetics include

1. ADRENALINE,
2. ISOPROTERENOL,
3. EPHEDRINE.

• These are non-specific as they act on beta-1 and alpha-1 receptors as well as beta-2-receptors.

Question 43

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

2. Sympathomimetics:

ADRENALINE

At which receptor does express Bronchodilation?

When is it used?

Administration in cats?

Used in combination with? To do what?

Also used to ? in bleeding

Answer 43

Adrenaline:

• Bronchodilation at β2 receptors (and other receptors).
• They are only used in life-threatening cases

(e.g. anaphylaxis - also treated with antihistamines and glucocorticoids).

• Their dose is 0.1-0.5 mg/dog.
• In the cat it is administered i/v, i/m or intratracheal and, in case of cardiac stop, intracardially.
• It is also used in combination with LIDOCAINE to prolong the action of this local anaesthetic and to avoid the systemic effects of lidocaine.
• It is also used to constrict the blood vessels i.e.
  
  • in bleeding.

Question 44

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

2. Sympathomimetics:

ISOPROTENOL

Answer 44

Isoproterenol:

• Similar to adrenaline but it acts on the
  
  • beta-1 and
  • beta-2-receptors only.
• It is applied in infusion.

Question 45

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

2. Sympathomimetics:

EPHEDRINE

Answer 45

Ephedrine (Bronchopect A.U.V.):

• Directly and indirectly, acting sympathomimetic.
• It has several mild side effects.
• It is a bronchodilator (also has other indications).
• It causes tachyphylaxis.
• Its dose is 1-2 mg/kg orally BID-TID.
  
  • This dose must be increased within days in order to have the same biological effect.
• It acts on the
  
  • beta-1,
  • beta-2 and
  • alpha-1 receptors at the same time.

Question 46

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Drug/receptor interaction

Adrenalin

Ephedrine

Isoproterenol

Answer 46

Question 47

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

1. Sympathomimetics
2. Specific sympathomimetic
3. Receptor
4. Selectiveness
5. Side effects
6. Contra indication
7. Broken up into?

Answer 47

• The specific sympathomimetics are:
  
  • beta-2 agonists.
  • Bronchodilators at the β2
• Receptors (and have a variable β1 receptorial effect).
  
  • These are not selective i.e.
    
    • they will have an effect on beta-1-receptors also which has a positive inotropic and chronotropic effect on the heart i.e. the side effects include
      
      • tachycardia,
      • restlessness,
      • tremors
      • Decreased uterine contraction.
  • Its contraindications include
    
    • congestive heart failure,
    • arrhythmia and
    • decreased mast cell degranulation.
  • They can be broken up into
• short- (1-4 hours) and
• long-acting (6-12 hours).

Question 48

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

1. The short-acting specific sympathomimetics include
2. Ratio receptor
3. Safety
4. Side effects
5. Oral administration
6. Inhaled administration
7. How to alleviate the broncho construction in asthma atacs

Answer 48

The short-acting specific sympathomimetics include

1. SALBUTAMOL

• This drug has a β2:β1 ratio of approx.
• 650:1 meaning it is extremely safe to use but you cannot exclude its action on beta-1-receptors also i.e.
• side effects include
  
  • tachycardia,
  • tremors,
  • palpation,
  • excitation
• When administered orally, it takes up to 30 mins to work and when it is
  
  • Inhaled, it shows effects in 5 minutes.
• These effects last for 1-4 hours.
• Its dosage, when inhaled, is 100-200 μg/cat and 400-800 μg/horse.
• When it is given orally, its dose is 20-60 μg/kg dog, cat and 8 μg/kg horse.
• This is usually the first choice to alleviate bronchoconstriction in an asthamatic attack.

Question 49

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

1. Long-acting specific sympathomimetics include
2. Isoprotrenol and ephedrine can cause
3. Beta-2-adrenoreceptor agonist cause
4. Alpha-adreboreceptor activity causes
5. Adrenergic agonist can all cause

Answer 49

1. TERBUTALINE,
2. CLENBUTEROL,
3. SALMETEROL.

• Isoproterenol and Ephedrine (beta-1-receptor activity) can cause
  
  • cardiac effects including
    
    • tachycardia and
    • arrhythmias.
• Beta-2-adrenoreceptor agonists cause
  
  • skeletal muscle tremors.
• Alpha-adrenoreceptor activity causes
  
  • vasoconstriction and
  • hypertension.
• Adrenergic agonists can all cause
  
  • tachycardia.
  • Again, these effects are minimized by inhalant delivery

Question 50

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

TERBUTALINE

1. Specificity
2. Duration of action
3. Dose
4. Administration
5. Used for
6. Type of animals
7. Pulse above 200/min indicates

Answer 50

Terbutaline (Bricanyl®)

• Less specific
• Acts for 6-8 hours.
• Its dose is 0.312-0.625 mg/cat and 0.625-5 mg/dog orally TID.
• It is administered subcutaneously, i/v or inhaled.
• It is used for feline asthma, organophosphate toxicosis:
  
  • 5-7 puffs (auscultation! → 240/min) i.e.
  • do not apply again so easily.
  • It is usually used in small animals e.g. cats.
    
    • If the pulse is above 200/min, then it is an indication that you applied a higher dose than necessary.

Question 51

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

CLENBUTEROL

Specoficity

duration of action

Less effective in

Probibited = in case of

Answer 51

• Less specific
• Action of 6-8 hours.
• It is less effective in companion animals but is frequently used in horses (1-3 μg/kg orally).
• Its beta-2:beta-1 receptor ratio is
  
  • 4:1.
• It is less effective in companion animals.
• It is prohibited to administer in food-producing animals
  
  • because they cause the meat to have less fat content (this is forbidden), and racehorses because this is a doping agent.

Question 52

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

SALMETEROL

• specificity
• duration
• economics

Answer 52

Salmeterol (Serevent®)

• is the most specific (50000:1)
• and also has the longest duration (10 mins-12 hours).
• Unfortunately, it is also the most expensive.
• Its dosage is 200 μg/horse.

Question 53

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Answer 53

Parasympatholytics:

• These are acetylcholine antagonists (M3-receptors).
• They cause
  
  • bronchodilation and
  • decreased mucus secretion.
• Their side effects include
  
  • tachycardia (because of anticholinergic effect),
  • mydriasis,
  • decreased mucociliary clearance (helps the body to remove irritants and contaminants) and
  • paralytic ileus (Eq).
• Their indications are
  
  • asthma (Fe),
  • horse RAO and
  • organophosphate toxicosis.
• These include

1. ATROPINE,
2. GLYCOPYRROLATE,
3. IPRATROPIUM.

*

Question 54

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

ATROPINE

1. Type of drug
2. Administration
3. Dose
4. Side effects

Answer 54

Atropine:

• This is a tertiary amine i.e.
  
  • crosses the BBB.
• It is mainly administered sc or i/v.
• Its dose is
  
  • 0.02-0.04 mg/kg when used for bronchodilation (not usually our first choice for this) and
  • 0.2-2 mg/kg in organophosphate toxicosis.
• Its side effects, as well as what is mentioned above
  
  • Includes CNS signs in cats.
    *

Question 55

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

GLYCOPYROLATE

1. Duration of action?
2. safety?
3. does it cross BBB?
4. Used in cats?

Answer 55

Glycopyrrolate:

• This drug has a longer action
• and is much safer.
• It cannot cross the BBB and
• can be used in cats.

Question 56

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

IPRATROPONIUM

1. Type of drug
2. route of administration
3. Does it cross BBB
4. Usefull in
5. Onset of action
6. Combination?
   
   1. ​Causes?

Answer 56

Ipratropium (Atrovent®):

• This drug is a quaternary amine.
• For administration, only inhalation is safe.
• It does not cross BBB.
• It is useful for mucociliary clearance.
• This drug’s onset of action is slower (15-30 mins)
  
  • but it can last for up to 6 hours
• Can be administered in combination with Salbutamol,
  
  • this can cause a quick onset and a prolonged effect at the same time.

Question 57

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Methylxanthine derivatives:

Answer 57

Methylxanthine derivatives:

1. CAFFEINE,
2. THEOPHYLLINE,
3. THEOBROMINE.

Question 58

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Methylxanthine derivatives:

Answer 58

Methylxanthine derivatives:

1. CAFFEINE,
2. THEOPHYLLINE,
3. THEOBROMINE.

Their mechanism of action is that they are phosphodiesterase inhibitors i.e

• cAMP level increases
  
  • leading to bronchodilation.
• They have various pharmacological effects.
• Their pharmacokinetics include
  
  • good absorption,
  • enterohepatic

circulation (→ activated carbon).

• Their side effects are due to their
  
  • small therapeutic index,
  • Leading to cardiovascular and
  • Gastrointestinal diuresis.
• Their indications are
  
  • Bronchitis,
  • Pneumonia etc.
• They are administered i/v or orally as retard tablets.

Question 59

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Methylxanthine derivatives:

Derivatives of theophylline

1. Include
2. Therapeutic use
3. Adverse effect include

Answer 59

• Derivatives of theophylline include

1. AMINOPHYLLINE,
2. PROPEMTOPHYLLINE,
3. PENTOXIFYLLINE.

• Their therapeutic uses are to treat
  
  • Acute or chronic asthma that is unresponsive to β-adrenoceptor agonists;
    
    • they can be administered prophylactically.
• These agents are also used to treat chronic obstructive lung disease (COPD) and emphysema.

Their adverse effects include

• arrhythmias,
• nervousness,
• vomiting
• gastrointestinal bleeding.

Question 60

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

2. Respiratory antiinflammatory drugs:

1. Indication
2. Drugs can be either

Answer 60

• Their indications include
  
  • Asthma and
  • RAO.
• They can be either
  
  • inhalation glucocorticoids
  • chromanes
  • leukotriene antagonists

Question 61

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Inhalation glucocorticoids: ​

1. Function
2. Cause inhibition of ? Leading to?
3. IL-4 and IL-5 cause ?
4. Is systemic application possible
5. Side effects
6. Inhalation?
7. Drugs?

Answer 61

Inhalation glucocorticoids:

• These are the most effective anti-inflammatories.
• They cause inhibition of the expression of several genes
  
  • which leads to the decrease of cytokine production of
    
    • IL-4 and IL-5.
• They cause eosinophil apoptosis
  
  • Due to decreased mucus production and
  • An increasing diameter.
• Systemic application is possible
  
  • ​but this has several side effects including in the
    
    • HT-HP axis,
    • stomach,
    • liver etc.
• Because of this, they are mainly inhaled for less frequent side effects.
• When inhaled, they affect
  
  • 15-20% airways and
  • 80-85% pharynx (due to the first pass effect). ​

1. ​BECLOMETHASONE,
2. FLUTICASONE.

• Beclomethasone: (14x dexamethasone) 500-1500 g/horse BID
• Fluticasone: (23x dexamethasone) 100-200 g/cat BID, 2000 g/horse BID

Question 62

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Chromanes:

1. Cause inhibition of? Therefor they are?
2. Administration route
3. Used in
4. Drugs
5. Administered?

Answer 62

Chromanes:

• These cause the inhibition of mast cell degranulation i.e.
  
  • they are mast cell stabilizers.
• They can be administered orally or inhaled.
• They are used rarely in cases of asthma.

1. Na-CHROMOGLYCATE,
2. NEDOCROMIL.

• They are administered
  
  • orally,
  • inhanled
  • used as an eye drop (externally).

Question 63

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Leukotriene antagonists:

1. What are they?
2. What are they?
3. They convert ? into ?
4. They can cause ?
5. Leukotriene synthesis include?
6. Administration?
7. Leukotriene antagonist include
8. Administration route in case of feline asthma
9. 3 strategies
10. Montelukast, Zafirlukast and Pranlukast are?

Answer 63

Leukotriene antagonists:

• Leukotriene synthesis inhibitors.
• These are the final products of the lipoxygenase pathway.
• They convert arachidonic acid to cysteinyl leukotrienes (LTC4, LTD4, LTE4)
• They can cause
  
  • Bronchoconstriction,
  • Mucous production
  • Oedema.
• Leukotriene synthesis inhibitors include

1. ZILEUTON,
2. FENLEUTON

• Administered orally.
• Leukotriene antagonists include

1. ZAFIRLUKAST,
2. MONTELUKAST.

• These are also given orally in cases of feline asthma: 0.5-1 mg/kg SID, BID.
• Inhibition of 5-lipoxygenase by the drug zileuton reduces the biosynthesis of leukotrienes.
• A second strategy involves inhibition of the cysteinyl leukotriene receptor CysLT1.
• Montelukast, zafirlukast, and pranlukast are CysLT1 receptor antagonists.
• A third strategy involving inhibition of the protein that activates 5-lipoxygenase (5-lipoxygenase-activating protein or FLAP) is being actively explored.

Question 64

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

3. Antitussives:

1. What is it
2. What to observe
3. What to administer for a dry cough
4. Which senter do we block
5. What to apply for a wet cough and why?
6. The pathway of a cough?
7. Peripheral antitussives include
8. Central antitussives include

Answer 64

3. Antitussives:

• Any medicine used to suppress or relieve coughing.
• With coughing, you must observe whether the cough is
  
  • Wet
  • Dry.
    
    • If it is a dry cough, we administer antitussives.
• This means that we can block/suppress the activity of the respiratory center.
• We can either apply
  
  • Mucolytics
  • Expectorants
    
    • if the cough is wet
  • Which will help to decrease the viscosity and make it easier for the animal to cough up.
• Coughing causes an impulse from the trachea or bronchi (irritation, inflammation, mechanical, ACE inhibitors etc.)
• Which reaches the afferent sensory neurons
• Which then reaches the cough center (medulla oblongata).
• Peripheral antitussives include:
  
  • mucolytics
  • expectorants
  • bronchodilators
  • coating substances
  • local anesthetics.
• Central antitussives include morphine derivatives.

Question 65

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

3. Antitussives:

Central antitussives include morphine derivatives.

Answer 65

1. Codeine vs morphine:
   
   1. These have a better bioavailability orally. They have 10 times lower analgesic potency and are similar to antitussives.
   2. They rarely have side effects but in the cat, they can cause
      
      1. excitation,
      2. convulsions,
      3. sedation and
      4. constipation.
   3. Their dose is 1-2 mg/kg BID-QID.
2. Dihydrocodeine:
   
   1. ​This is more effective but cannot be administered to cats.
3. Hydrocodone
4. Butorphanol:
   
   1. This is the most effective but can cause sedation.
   2. It is an oral product.
5. Tramadol: Used in dogs at 5mg/kg every 6 hours.
6. Dextromethorphan:
   
   1. This is a δ-receptor,
   2. non addictive,
   3. non analgesic.
   4. It is also safe in cats.
   5. Its dose is 1-2 mg/kg orally TID-QID.

Question 66

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

4. Mucolytics:

Indication

Mechanism of action

Drugs

Answer 66

4. Mucolytics:

• The indications for these drugs include
  
  • bronchitis,
  • bronchopneumonia,
  • tracheitis,
  • rhinitis,
  • sinusitis and for
  • RAO as adjunctive therapy.
• Their mechanism of action is the
  
  • dissolution of the dense, sticky mucus inside the respiratory tract
    
    • which leads to productive coughing.
    • The clinical signs can be more pronounced ( antitussives).

Question 67

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

Mucolytic drugs

Answer 67

1. N-ACETYLCYSTEINE: (ACC®, Fluimucil®)

• This drug causes the breaking up disulfide bonds in mucoproteins
  
  • which leads to the dissolution of viscous mucus.
  • This leaves a bad taste and odour.
• ​​​They are administered orally or inhaled.
• They cause AB penetration
• Their dose is 50 mg/kg orally BID, TID.
• They are also an antidote of paracetamol when administered i/v.

CARBOCYSTEINE

These have a similar action, their oral absorption is better.

Question 68

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

5. Expectorants:

Answer 68

5. Expectorants:

• These act
  
  • Directly on the mucous membrane of airways (volatile oils e.g. eucalyptus, thymus, turpentine) or
  • Indirectly by stimulating gastric mucous membrane via salts (pl. NH4Cl, NaI)
    
    • Ipecacuanha,
    • Guaifenesin.

1. Bromhexin:
2. Ambroxol: metabolite of bromhexine
3. Dembrexine: horse, longer half-life (iv. → po.)
4. Guaifenesin: This drug does not change the amount of mucous secretion. It enhances ciliary movement (MC ). It can be combined with antitussives.

Question 69

27-28: PHARMACOLOGY OF THE RESPIRATORY SYSTEM

Drugs acting on the respiratory system:

Parasympatholytics:

5. Expectorants

BROMHEXIN

Answer 69

Bromhexin: (Bisolvon A.U.V., Ventipulmin A.U.V.).

• This drug has 3 actions.

1. The first is the breaking up of mucopolysaccharides, dissolving mucus.
2. The second is increase the secretion of the serous glands
3. The third is enhancing ciliary movement.

• These cause enhancing permeation of
  
  • Ig-s
  • ABs
• IgA, IgG levels are increased.
• Their indications include
  
  • rhinitis,
  • sinusitis and
  • tracheobronchitis (but lead to purulent discharge).
• Its dose is 2 mg/kg orally or subcutaneously BID.