Micronutrients Flashcards
Small molecule groups that are needed by the body to maintain normal physiologic functioning
MICRONUTRIENTS
MINERALS
- MAJOR
- MINOR (TRACE)
VITAMINS
- WATER SOLUBLE
- FAT-SOLUBLE
Concept Properties of Micronutrients
BIOAVAILABILITY
PRECURSORS
ORGANIC/INORGANIC NATURE
SOLUBILITY
TOXICITY
OVERLOAD SYNDROME
GENETIC ERRORS IN METABOLISM
Refers to the amount of a nutrient that the body can use that is of good quality
BIOAVAILABILITY
Factors that influence bioavailability
Increased bioavailability
❖Efficiency of digestion
❖Adequate nutrition status
❖Quality of nutrient absorbed
Factors that influence bioavailability
Decreased bioavailability
❖Source of nutrient
❖Method of food preparation
❖Foods that interfere with absorption (binders) are taken at the same time
Refer to the “inactive forms” or starting points from which other substances develop
PRECURSORS
Are descriptions about whether micronutrients can be altered or destroyed during the handling or preparation process as a result of their chemical composition
ORGANIC AND INORGANIC NATURE
Refers to the degree to which a substance can dissolve in a water or fat medium
SOLUBILITY
Refers to an excess of a substance that can cause harm or damage due to accumulation in the body
TOXICITY
Refers to minerals that can either be taken in or produced by the body leading to toxic levels of sodium, potassium, calcium and iron
OVERLOAD SYNDROME
Processes whereby there is insufficient production, absorption, or excretion of substances resulting in clinical deficiency states (too little) or excess states (too much)
GENETIC ERRORS IN METABOLISM
WATER SOLUBLE VITAMINS
*Vitamin B
*Vitamin C
Function as coenzymes throughout the body in a series of chemical reactions and binding sites
Vitamin B
Involved in metabolism of all macronutrients
Vitamin B
Vitamin B1
Thiamin
Coenzyme in CHO metabolism
Vitamin B1 - Thiamin
Dietary sources of Vitamin B1 - Thiamin
- Pork, wheat germ,, black eyed peas
- Fortified cereals and enriched grains
Vitamin B1 - Thiamin
Deficiency
- Beriberi
- Wernicke-Korsakoff syndrome
Excess Vitamin B1 - Thiamin
- Headache, irritability, insomnia
- Tachycardia and weakness
Neurological deficits (disorientation, short-term memory loss, jerky eye movements, staggered gait and weakness) that can lead to cardiac failure
Beriberi
Clinical state of encephalopathy seen in clients with alcoholism, noted by the presence of mental changes, psychosis and coma
Wernicke-Korsakoff syndrome
Vitamin B2
Riboflavin
Coenzyme in protein and energy metabolism and conversion of other vitamins into active forms (B6, niacin, folate and K)
Vitamin B2 - Riboflavin
Vitamin B2 - Riboflavin
Deficiency
- Ariboflavinosis
- Oral lesions
- Eye problems
Vitamin B2 - Riboflavin
Excess
Yellow-orange discoloration of urine
Refers to a clinical deficiency state that affects the skin, eyes, mouth, and tongue and results in the development of a normocytic anemia
Ariboflavinosis
Oral lesions such as ____________ (cracks at the corners of the mouth) and eye problems (photophobia, tearing, and burning)
cheilosis
Vitamin B3
Niacin
Functions as part of respiratory enzymes and is involved in energy expenditure
Niacin
Precursor to niacin is
tryptophan
Cholesterol lowering properties and causes peripheral vasodilation
Niacin
Vitamin B3 - Niacin
Deficiency
- Pellagra
- Drug interactions
- Carcinoid syndrome
- Hartnup disease
Pellagra
* Clinical deficiency state characterized by the three Ds:
dermatitis, diarrhea, and
dementia
can exist when serum blood tryptophan levels are low due to increased serotonin synthesis from tumors
Carcinoid syndrome
Rare genetic disorder that is characterized by decreased absorption of tryptophan with similar symptoms to those of pellagra
Hartnup disease
Coenzyme in metabolism that functions in the tricarboxylic cycle for release of energy
Biotin
Involved in gluconeogenesis
Biotin
Biotin
* Deficiency
- Large number of eggwhites in the diet
- Px with Phenylketonuria
- Long term TPN
- Protein energy malnutrition
- Biotindase deficiency
Biotin
Excess
- No toxic effects reported
- No UL has been indicated
Leads to functional biotin deficiency because high phenylalanine levels inhibit enzyme activity
Phenylketonuria
Genetic disorder that leads to clinical deficiency state resulting in delayed development, seizures, and rashes, fatal without biotin correction
Biotindase deficiency
Vitamin B5
Panthothenic acid
Coenzyme in metabolism that functions in the tricarboxylic cycle for release of energy
Vitamin B5 - Panthothenic acid
Vitamin B5
*Deficiency
- Fatigue, paresthesias, weakness, and leg cramps
- Neurological manifestations (restlessness and irritability)
- Burning feet syndrome
Vitamin B5
Excess
- Diarrhea can occur with excess levels of this vitamin
- Fluid retention can occur with excess levels of this vitamin
Vitamin B6
Pyridoxine
Coenzyme in amino acid, lipid and protein metabolism (gluconeogenesis), erythrocyte function, modulation of hormones
Vitamin B6 - Pyridoxine
Made by intestinal bacteria in the body
Vitamin B6 - Pyridoxine
Used in the synthesis of DNA and helps convert Vit.B12 to a coenzyme form in the body
Folic Acid
Growth and development of RBCs
Folic Acid
Increased need is seen during pre pregnancy and antenatal periods for its effect on preventing neural tube defects and allowing normal spinal cord development
Folic Acid
Associated with folic acid deficiency in pregnant women and result in spinal deformities of the fetus
Neural tube defects
Large immature cells with a decreased oxygen-carrying capacity
Megaloblastic anemia
This can occur due to impaired DNA synthesis
Megaloblastic anemia
is used as a biochemical marker for correlation of presence of neural tube defects and certain cancers in the body
AFP (Alpha feto protein)
Vitamin B12
cobalamin/cyanocobalamin
Coenzyme in the synthesis of hemoglobin, RBCs and DNA
Vitamin B12 - cobalamin/cyanocobalamin
Vitamin C
Ascorbic acid
Antioxidant function
Vitamin C - Ascorbic acid
Synthesis of neurotransmitters, hormones, and bile acids, metabolism of amino acids and breakdown of fatty acids
Vitamin C - Ascorbic acid
Enhances folic acid conversion and iron absorption
Vitamin C - Ascorbic acid
Structural component involved in collagen formation in the body
Vitamin C - Ascorbic acid