microminerals and ultratrace minerals Flashcards
What is the third largest trace element in the human body?
Copper.
What are the sources of copper?
Seafood (oysters, crabs), liver, nuts (sesame & sunflower seeds), soy products, legumes, cocoa.
What are the functions of copper?
Essential for enzyme function, nutrient metabolism, immune function, connective tissue integrity, red blood cell and connective tissue formation, collagen production, oxidative reaction enzymes, and neurotransmitter production (norepinephrine, dopamine).
What causes copper deficiency?
High zinc intake or total parenteral nutrition (TPN).
What are the symptoms of copper deficiency?
Reduced skin/hair pigmentation, low white blood cell count, poor collagen cross-linking, osteoporosis, arthritis, spontaneous fractures, arterial disease.
What causes copper toxicity?
Increased levels in rheumatoid arthritis, myocardial infarction, estrogen therapy, pregnancy, and Wilson disease.
What is Wilson disease?
Excess copper accumulation in the liver, brain, kidney, and cornea (Kayser-Fleischer ring).
What are the sources of selenium?
Seafood, liver, kidney, meats, dairy, eggs, whole grains, nuts, mushrooms.
What makes selenium more bioavailable?
Dairy and eggs.
What are the functions of selenium?
Role in enamel and dentin health, cofactor for antioxidant enzyme, protects lipids, proteins, nucleic acids, contributes to immune function, skeletal integrity, and works with vitamin E as an antioxidant.
Where is selenium present in the body?
In tooth enamel and dentin.
What is a selenium deficiency?
Keshan disease (cardiomyopathy).
What are the symptoms of selenium toxicity?
Liver cirrhosis, nausea, vomiting, weakness, dermatitis, hair loss, white blotchy nails, garlicky breath.
Can selenium toxicity promote dental caries?
Yes, if consumed pre-eruptively.
Are selenium toxicity symptoms common in humans?
No, they are rarely seen in humans, mostly in animals due to irregular soil distribution.
What are the sources of chromium?
Meats, whole grains, wheat germ, nuts, mushrooms.
What are the symptoms of chromium deficiency?
Decreased insulin sensitivity, glucose intolerance, increased diabetes risk.
What are the functions of chromium?
Regulates glucose metabolism, assists lipid breakdown, involved in carbohydrate & lipid metabolism, enhances insulin action, glycemic control in individuals with type 2 diabetes.
What are the symptoms of chromium toxicity?
Liver damage, lung cancer.
What are the sources of manganese?
Whole grains, legumes, leafy greens, nuts, tea, infant formula.
What are the functions of manganese?
Prevents osteoporosis, supports bone health and metabolism, essential for multiple enzyme systems, important for bone matrix development, involved in insulin production, helps amino acid, cholesterol, and carbohydrate metabolism.
Are manganese deficiency symptoms common?
No, deficiency is not reported in normal diets.
What are the symptoms of manganese toxicity?
Ataxia, headache, fatigue, anxiety, Parkinson-like symptoms (“Manganese madness”).
What environmental issue can contribute to manganese toxicity?
Environmental contaminants.