Microbiology: Rickettsia Flashcards

1
Q

What type of organism is rickettsia?

A

obligate intracellular parasite of eukaryotes

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2
Q

How is rickettsia spread?

A

arthropod vectors

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3
Q

What do rickettsia infect?

A

endothelial cells of the vascular system

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4
Q

What happens when an animal has a rickettsia infection?

A

resulting inflammation causes local blockage and rupture of small blood vessels

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5
Q

What kind of disease is Rickettsia rickettsii?

A

zoonotic

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6
Q

What is Rickettsia rickettsii also known as?

A
  1. Tickborne typhus

2. Rocky Mountain Spotted Fever

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7
Q

What is the vector for Rickettsia rickettsii?

A

ticks

  • wood tick
  • dog tick
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8
Q

Where are these vectors found?

A

Western USA: wood tick

Eastern USA: dog tick

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9
Q

What is the reservoir for Rickettsia rickettsii?

A

dogs

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10
Q

Where is the US is Rickettsia rickettsii found?

A

all states

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11
Q

What states have the highest concentration of ticks? (aka the tick belt)

A
  • Maryland
  • Virginia
  • North Carolina
  • South Carolina
  • Georgia
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12
Q

How many ticks in the tick belt are infected?

A

50%

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13
Q

How many tick bites spread disease?

A

1-2%

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14
Q

What is the mortality rate in Montana?

A

90% if not treated

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15
Q

What is the mortality rate in other areas beside Montana?

A

5% if not treated

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16
Q

How long does it take for a tick to spread Rickettsia rickettsii?

A

4 hours

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17
Q

What are the human symptoms for Rickettsia rickettsii?

A
  • high fever, several days

- rash on the skin that starts on the palms and soles then spreads

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18
Q

How long does a human rash from Rickettsia rickettsii last?

A
  • duration of infection without treatment

- 2 weeks with treatment or when person dies

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19
Q

What are the canine symptoms for Rickettsia rickettsii?

A
  • high fever (105* F)
  • anorexia
  • cough
  • edema
  • petechial hemorrhage
  • altered mental state
  • retinal hemorrhage
20
Q

How is Rickettsia rickettsii prevented?

A

vaccine made from inactivated cells grown in chock embryo cell cultures

21
Q

What happens if a human or dog recovers from Rickettsia rickettsii?

A

permanent immunity

22
Q

What is Rickettsia prowazekii also known as?

23
Q

When is Rickettsia prowazekii a major epidemic disease?

A
  • during war-time
  • crowded and dirty conditions
  • Anne Frank died of typhus
24
Q

What are the reservoirs for Rickettsia prowazekii?

A

humans
eastern flying squirrel
lice

25
How is Rickettsia prowazekii spread?
by squirrel fleas
26
Humans can carry the organism Rickettsia prowazekii for years in a ______ infection. Then, get a milder form of the disease known as __________.
1. latent | 2. Brill's Disease
27
Why can people get a milder disease after carrying Rickettsia prowazekii for a period of time?
they will have partial immunity
28
What is the most effective way to control Rickettsia prowazekii?
environmental prevention
29
Who has access to a vaccine against Rickettsia prowazekii? (typhus)
military personnel
30
What drugs are used to treat a Rickettsia prowazekii infection?
- tetracycline | - chloramphenicol
31
What is another name for Rickettsia typhi?
Endemic Murine Typhus
32
What kind of disease can Rickettsia typhi cause?
- zoonotic | - sporadic occurrence
33
What is murine Latin for?
mouse
34
Who are the common hosts for Rickettsia typhi?
- rodents - rats - mice
35
How is Rickettsia typhi transmitted?
rodent flea
36
How is Rickettsia typhi similar to epidemic typhus?
- similar symptoms | - less severe
37
What drugs are used to treat Rickettsia typhi?
1. tetracycline | 2. chloramphenicol
38
What is Rickettsia akari also known as?
Rickettsial Pox
39
What kind of pathogen is Rickettsia akari?
zoonotic
40
What is the reservoir for Rickettsia akari?
common house mouse
41
How is Rickettsia akari spread?
infected mouse mites
42
What does a flea bite from a flea infected with Rickettsia akari do to the body?
- causes lesions at the site of the bite | - fevers and chills early on
43
What happens 3-4 days after a Rickettsia akari infection?
rash (pox) develops
44
How can Rickettsia akari be controlled?
by controlling the rodent population
45
What drugs are used to treat Rickettsia akari?
- tetracycline | - chloramphenicol