MHCs B6 Flashcards
Tc cells (CD-8) recognize peptides bound to which MHC class?
MHC class I
Th cells (CD-4) recognize peptides bound to which MHC class?
MHC class II
________ is key player in normal immune response.
MHC (Major Histocompatibility Complex)
MHC is located on short arm of _______________
Chromosome 6
All nucleated cells have which class?
MHC class I
All antigen presenting cells have which class?
MHC class II
Question he had on on slide 9… didnt catch it…?
Because every cell may need to be removed from the body if it misbehaves.
Endogenous/ ______________ antigens are presented by MHC __ and presented to _____________.
Not Phagocytized
MHC I
Tc lymphocytes (CD-8)
e.g. Cancer, viruses
Exogenous antigens/ ____________ material, presented by ________, presented to ___________________.
Phagocytized
Presented by MHC II
Presented to Th lymphocytes (CD-4)
e.g. bacteria
___ is docking station for CD8
Alpha3
___ and ___ regions are polymorphic and bind Ag fragment for presentation to Tc cell.
Alpha1 and Alpha2
If antigen only has one chain/ tail which MHC is it?
MHC I ( only pierces cell membrane once)
Endogenous what MHC?
MHC I
Exogenous what MHC?
MHC II
If antigen has 2 chains/ tails which MHC is it?
MHC II
T-cells cannot respond to ____________ antigens.
unprocessed
Little tiny piece of an antigen, the piece that T-cells look at and respond to. Antigens are covered in these.
Epitope
A substance that is capable of reacting with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other molecule.
Hapten
Antigens are phagocytized and digested in ______________.
acidic lysosomes
Vessicles containing MHC-II fuse with _________.
lysosomes
Macrophage antigen processing and presentation…MHC-II
Peptide complexes are transported to surface where they interact with and activated CD4 cells that are specific for the peptide.
2 signals required to activate immune response
T cell receptor binding to MHC
Engagement of co-stimulatory molecules alone= (anergy- nothing will take place, lack of immune response)
What happens
Antigen presenting cells processes
Comes up and presents via a macrophage
T cells receive a co-stimulatory signal
Co-stimulation with accessory
MHC II is being presented by a ____________
Macrophage
TH1 is ___________ response
cell mediated
TH2 cells promote ________________ responses
antibody- mediated
What cells don’t have MHC-I?
Red blood cells
