MHCs B6

Question 1

Tc cells (CD-8) recognize peptides bound to which MHC class?

Answer 1

MHC class I

Question 2

Th cells (CD-4) recognize peptides bound to which MHC class?

Answer 2

MHC class II

Question 3

________ is key player in normal immune response.

Answer 3

MHC (Major Histocompatibility Complex)

Question 4

MHC is located on short arm of _______________

Answer 4

Chromosome 6

Question 5

All nucleated cells have which class?

Answer 5

MHC class I

Question 6

All antigen presenting cells have which class?

Answer 6

MHC class II

Question 7

Question he had on on slide 9… didnt catch it…?

Answer 7

Because every cell may need to be removed from the body if it misbehaves.

Question 8

Endogenous/ ______________ antigens are presented by MHC __ and presented to _____________.

Answer 8

Not Phagocytized
MHC I
Tc lymphocytes (CD-8)
e.g. Cancer, viruses

Question 9

Exogenous antigens/ ____________ material, presented by ________, presented to ___________________.

Answer 9

Phagocytized
Presented by MHC II
Presented to Th lymphocytes (CD-4)
e.g. bacteria

Question 10

___ is docking station for CD8

Answer 10

Alpha3

Question 11

___ and ___ regions are polymorphic and bind Ag fragment for presentation to Tc cell.

Answer 11

Alpha1 and Alpha2

Question 12

If antigen only has one chain/ tail which MHC is it?

Answer 12

MHC I ( only pierces cell membrane once)

Question 13

Endogenous what MHC?

Answer 13

MHC I

Question 14

Exogenous what MHC?

Answer 14

MHC II

Question 15

If antigen has 2 chains/ tails which MHC is it?

Answer 15

MHC II

Question 16

T-cells cannot respond to ____________ antigens.

Answer 16

unprocessed

Question 17

Little tiny piece of an antigen, the piece that T-cells look at and respond to. Antigens are covered in these.

Answer 17

Epitope

Question 18

A substance that is capable of reacting with a specific antibody but cannot induce the formation of antibodies unless bound to a carrier protein or other molecule.

Answer 18

Hapten

Question 19

Antigens are phagocytized and digested in ______________.

Answer 19

acidic lysosomes

Question 20

Vessicles containing MHC-II fuse with _________.

Answer 20

lysosomes

Question 21

Macrophage antigen processing and presentation…MHC-II

Answer 21

Peptide complexes are transported to surface where they interact with and activated CD4 cells that are specific for the peptide.

Question 22

2 signals required to activate immune response

Answer 22

T cell receptor binding to MHC

Engagement of co-stimulatory molecules alone= (anergy- nothing will take place, lack of immune response)

Question 23

What happens

Answer 23

Antigen presenting cells processes
Comes up and presents via a macrophage
T cells receive a co-stimulatory signal
Co-stimulation with accessory

Question 24

MHC II is being presented by a ____________

Answer 24

Macrophage

Question 25

TH1 is ___________ response

Answer 25

cell mediated

Question 26

TH2 cells promote ________________ responses

Answer 26

antibody- mediated

Question 27

What cells don’t have MHC-I?

Answer 27

Red blood cells