Antibodies Flashcards
Macrophages connec to what tail?
Fc tail
Where do antigens bind?
Fab
What is a large y shaped glycoprotein?
Antibodies
Antibodies are produced by ______.
B-cells
An antibody will be either _____ or ______.
Kappa or Lambda
This regulates cellular immunity.
TH1
This regulates humoral immunity.
TH2
________ bond is what holds the light chains together.
Disulfide
__ is the only antibody to cross the placenta via Fcgamma receptors.
IgG
___ and __ fix complement.
IgG and IgM
This antibody has pentamers or monomers structure. First Ig to be made in fetus, first to be made by virgin Ag-stimulated B-cells
IgM= primary immune response
What is the difference between plasma and serum?
Serum has used up the clotting factors.
Does IgA fix complement?
no, because IgA is on our mucus membrane we don’t want inflammation to occur there. (in our gut)
This is the major class of Ig in secretions, important in mucosal immunity.
IgA
This is found on B cell surfaces and can bind to Antigens.
IgD
Is a B-cell an antigen presenting cell?
Yes, B-cells produce antibodies. So, they are technically an antigen presenting cells.
All mast cells are located in ______.
Tissues
This antibody is least common Ig in plasma. Binds tightly to FcE receptors on basophils and mast cells.
IgE
What happens to BP when you have a lot of histamine in the system?
Blood pressure plummets
What is involved in allergic reactions
FcE receptors and mast cells
What is involved in parasitic infections
IgE and Eosinophils
What is unique to each class?
Heavy chains
IgE (from previous exposure) is docked on ________
Mast cells
We are infected but have not started to make antibodies.
Viral window
WIth HIV it is not very __________ so you could see someone in the viral window for up to 6 months.
immunogenic
Someone could be tested and not have antibodies, but they could still have it.
What immunity is where subject actively produces their own antibodies. Requires exposure to infectious agent.
Active
- Natural infection
- Artificial= immunization with altered agent or it’s antigens
An immunization can be ____ or _______. What did you get immunized with?
active or passive
What is another name for antibodies?
immune globulins
What immuity is where subject receives exogenous antibodies. Does not confer long term immunity.
Passive
- Natural= Mother-child (IgG-placenta, IgA- breast milk)
- Artificial= Immunization with antibodies
This immunity is not immediate but is long lived.
Active immunity
What immunity is immediate but short-lived. Natural maternal antibodies (IgG) crosses placenta.
Artificial= immune globulins
Antivenom/Antitoxin
Passive
If he gives a question about immunity, read on to see if it is active or passive.
do it
