Hemolytic disease Flashcards
Fetal maternal bleed releases ___________ into mom’s circulation.
Rh+ rbcs
Subsequent pregnancy with RH+ fetus puts baby at risk, what is the isotype of these antibodies?
IgG
Byproduct of lysis of blood.
Bilirubin
Discoloring (yellow) of baby and is toxic to the brain.
Bilirubinemia
This will coat and lyse any baby blood cells.
Rhogam
While receiving blood, a patient suddenly loses consciousness, and goes into shock. If this is due to a hypersensitivity what type could it be?
Type 1- Allergic
Type 2- Immune complex
_____________ formed in the circulation are deposited on vessel linings and/or tissues.
Immune complexes
-elicit inflammatory response via complement
If pt gets a shot and arm turns red what is it likely to be?
Arthus reaction
TrueFalse: Complement can activate mast cells like IgE does.
True
_________ is a systemic ‘Arthus reaction’
Serum sickness= generalized inflammation
Type 1=
IgE
Type 2 and Type 3
IgM and IgG
______ orchestrate Type 4 HS- Delayed type Hypersensitvity reactions.
CD4
What are the key cells in Type 4?
T-helper 1 cells and macrophages, antigen specific cytotoxic T-lymphocytes
Type 4 usually requires ____ to present.
days
The oil on poison oak is a toxin and is a type __ .
Type 4 Delayed
Half of an antigen
Hapten
True/False: Hapten needs a protein to bound to it for it to work.
True
What is a late-phase reaction?
leukotrienes, much stronger reaction
True/False: PPD skin test is actually an induration not inflammation. Type 4
True, hard little not or swollen area that is not red or inflamed.
Self- antigens are sometimes recognized by ________. This causes failure of self-tolerance.
Lymphocytes
WIth MS Pathogenic T cells target ______, it is a basic protein and will be a type __.
Myelin
Type 4
The hormone that controls the thyroid.
Thyroid stimulating hormone
In hashimotos disease the _______ is getting destroyed. Hypothyroid
thyroid
In Hashomoto’s thyroiditis do you have high or low TSH and high or low fT4?
High TSH
Low fT4
In grave’s disease do you have high or low TSH and high or low fT4?
High fT4
Low TSH
Hashimotos is what type? and what is happening?
Type 4, T cell mediated thyroid destruction
Graves disease is what type? and what is happening?
Type 2 response and turns cell on (thyroid production)
Systemic lupus erythematosis is what type?
Type 3, circulating IC, multi organ problem
