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Semester 2 Immunology > Hemolytic disease > Flashcards

Hemolytic disease Flashcards

1
Q

Fetal maternal bleed releases ___________ into mom’s circulation.

A

Rh+ rbcs

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2
Q

Subsequent pregnancy with RH+ fetus puts baby at risk, what is the isotype of these antibodies?

A

IgG

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3
Q

Byproduct of lysis of blood.

A

Bilirubin

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4
Q

Discoloring (yellow) of baby and is toxic to the brain.

A

Bilirubinemia

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5
Q

This will coat and lyse any baby blood cells.

A

Rhogam

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6
Q

While receiving blood, a patient suddenly loses consciousness, and goes into shock. If this is due to a hypersensitivity what type could it be?

A

Type 1- Allergic

Type 2- Immune complex

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7
Q

_____________ formed in the circulation are deposited on vessel linings and/or tissues.

A

Immune complexes

-elicit inflammatory response via complement

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8
Q

If pt gets a shot and arm turns red what is it likely to be?

A

Arthus reaction

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9
Q

TrueFalse: Complement can activate mast cells like IgE does.

A

True

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10
Q

_________ is a systemic ‘Arthus reaction’

A

Serum sickness= generalized inflammation

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11
Q

Type 1=

A

IgE

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12
Q

Type 2 and Type 3

A

IgM and IgG

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13
Q

______ orchestrate Type 4 HS- Delayed type Hypersensitvity reactions.

A

CD4

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14
Q

What are the key cells in Type 4?

A

T-helper 1 cells and macrophages, antigen specific cytotoxic T-lymphocytes

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15
Q

Type 4 usually requires ____ to present.

A

days

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16
Q

The oil on poison oak is a toxin and is a type __ .

A

Type 4 Delayed

17
Q

Half of an antigen

A

Hapten

18
Q

True/False: Hapten needs a protein to bound to it for it to work.

A

True

19
Q

What is a late-phase reaction?

A

leukotrienes, much stronger reaction

20
Q

True/False: PPD skin test is actually an induration not inflammation. Type 4

A

True, hard little not or swollen area that is not red or inflamed.

21
Q

Self- antigens are sometimes recognized by ________. This causes failure of self-tolerance.

A

Lymphocytes

22
Q

WIth MS Pathogenic T cells target ______, it is a basic protein and will be a type __.

A

Myelin

Type 4

23
Q

The hormone that controls the thyroid.

A

Thyroid stimulating hormone

24
Q

In hashimotos disease the _______ is getting destroyed. Hypothyroid

A

thyroid

25
Q

In Hashomoto’s thyroiditis do you have high or low TSH and high or low fT4?

A

High TSH

Low fT4

26
Q

In grave’s disease do you have high or low TSH and high or low fT4?

A

High fT4

Low TSH

27
Q

Hashimotos is what type? and what is happening?

A

Type 4, T cell mediated thyroid destruction

28
Q

Graves disease is what type? and what is happening?

A

Type 2 response and turns cell on (thyroid production)

29
Q

Systemic lupus erythematosis is what type?

A

Type 3, circulating IC, multi organ problem

Semester 2 Immunology (17 decks)

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