Hypersensitivity Flashcards
What regulates cellular immunity. Is protective -clear infected or mutant cells -activate macrophages Pathological -Cell-mediated hypersensitivities
TH1
This regulates humoral immunity.
Antibody-mediated hypersensitivities
TH2
Allergy/Anaphylactic/Atopy/Immediate
ACID
Type 1
Cell-bound antigen/Cytotoxic
ACID
Type 2
Immune Complex
ACID
Type 3
Delayed-Type
ACID
Type 4
Can a primary (first-time) exposure cause a true allergic reaction?
No
First exposure sensitized to allergen
Subsequent exposures damage
If something is IgE mediated what type is it?
Type 1!
IgE will dock on mast cells and ________-
Basophils
If you have systemic release of histamine what happens to Blood pressure?
It decreases
Early phase type 1 response
Degranulation:
Histamine and IgE related
Heparin
Eosinophil chemotactic factor A
Late-phase response (2-4 hrs post)
Arachidonic acid cascade
-leukotrienes are 1000 times more potent than histamine
SRS-A
Are leukotrienes!
Slow reacting substance of anaphylaxis!
Localized disorder of allergy
Atopy
Allergic rhinitis
Localized: hay fever
atopic dermatitis
Localized: Eczema
Urticatia
Localized: Hives
Swelling of face with anaphylaxis. is called what?
angioedema
This is complicated, allergic or non-allergic, has huge inflammatory component.
Asthma
Know flow chart of anaphylactic shock
Antigen exposure (Th-2 leads to IgE production (IL-4))
Antigen crosslinks IgEs on mast cells
Mast cells degranulate, release: Bronchiole constriction.
screw it just look at slide 11
What counters histamine and leukotrienes by relaxing bronchiospasm, reduces vascular permeability, and improves cardiac output
Epinephrine (adrenaline)
What is the least common immunoglobulin in plasma? Binds directly to FCe receptors on eosinophils. involved in allergic reactions
IgE
Type 1
IgE
Type 2
IgG or IgM
What is involved in parasitic infections?
binding of eosinophils to IgE-coated parasites results in killing of the parasite
Does IgE fix complement?
no
True/False: Eosinophils alone can’t attack parasites, they need IgE as well.
True
Half of an antigen (piece of antigen, drug can bind to membrane it can look like antigen and then you make antibodies to it.
Haptin
