Hypersensitivity

Question 1

What regulates cellular immunity. 
Is protective
-clear infected or mutant cells
-activate macrophages
Pathological
-Cell-mediated hypersensitivities

Answer 1

TH1

Question 2

This regulates humoral immunity.

Antibody-mediated hypersensitivities

Answer 2

TH2

Question 3

Allergy/Anaphylactic/Atopy/Immediate

Answer 3

ACID

Type 1

Question 4

Cell-bound antigen/Cytotoxic

Answer 4

ACID

Type 2

Question 5

Immune Complex

Answer 5

ACID

Type 3

Question 6

Delayed-Type

Answer 6

ACID

Type 4

Question 7

Can a primary (first-time) exposure cause a true allergic reaction?

Answer 7

No
First exposure sensitized to allergen
Subsequent exposures damage

Question 8

If something is IgE mediated what type is it?

Answer 8

Type 1!

Question 9

IgE will dock on mast cells and ________-

Answer 9

Basophils

Question 10

If you have systemic release of histamine what happens to Blood pressure?

Answer 10

It decreases

Question 11

Early phase type 1 response

Answer 11

Degranulation:
Histamine and IgE related
Heparin
Eosinophil chemotactic factor A

Question 12

Late-phase response (2-4 hrs post)

Answer 12

Arachidonic acid cascade

-leukotrienes are 1000 times more potent than histamine

Question 13

SRS-A

Answer 13

Are leukotrienes!

Slow reacting substance of anaphylaxis!

Question 14

Localized disorder of allergy

Answer 14

Atopy

Question 15

Allergic rhinitis

Answer 15

Localized: hay fever

Question 16

atopic dermatitis

Answer 16

Localized: Eczema

Question 17

Urticatia

Answer 17

Localized: Hives

Question 18

Swelling of face with anaphylaxis. is called what?

Answer 18

angioedema

Question 19

This is complicated, allergic or non-allergic, has huge inflammatory component.

Answer 19

Asthma

Question 20

Know flow chart of anaphylactic shock

Answer 20

Antigen exposure (Th-2 leads to IgE production (IL-4))
Antigen crosslinks IgEs on mast cells
Mast cells degranulate, release: Bronchiole constriction.
screw it just look at slide 11

Question 21

What counters histamine and leukotrienes by relaxing bronchiospasm, reduces vascular permeability, and improves cardiac output

Answer 21

Epinephrine (adrenaline)

Question 22

What is the least common immunoglobulin in plasma? Binds directly to FCe receptors on eosinophils. involved in allergic reactions

Answer 22

IgE

Question 23

Type 1

Answer 23

IgE

Question 24

Type 2

Answer 24

IgG or IgM

Question 25

What is involved in parasitic infections?

Answer 25

binding of eosinophils to IgE-coated parasites results in killing of the parasite

Question 26

Does IgE fix complement?

Answer 26

no

Question 27

True/False: Eosinophils alone can’t attack parasites, they need IgE as well.

Answer 27

True

Question 28

Half of an antigen (piece of antigen, drug can bind to membrane it can look like antigen and then you make antibodies to it.

Answer 28

Haptin