Metabolic Diseases Flashcards
what is a congenital disease
- metabolic disorders can be congenital (an animal born with a disorder) or acquired at birth
- can be hereditary or acquired in utero
- in most cases the hereditary component of metabolic disorders is a genetic predisposition to the disease and responds to environmental conditions
examples of congenital hereditary
- LFS = lavender foal syndrome
- HYPP = hyperkalemic periodic paralysis
examples of congenital aquires
- congenital hyperthyroidism
examples of aquired
- laminitis
examples of hereditary predisposition triggered by the environment
PSSM =equine polysaccharide storage myopathy
RER = recurrent exertional rhabdomyolysis
EMS = equine metabolic syndrome
examples of endocrine metabolic diseases
- cushings
- equine metabolic syndrome
examples of organ disfunction
- liver, kidney, lungs
examples of orthopedic disease
- developmental orthopedic disease
- arthritis
- fragile bone syndrome
what is ECD
- equine cushings dieases
- chronic, progressive neuroendocrine
- no cure
- treatment focused on managing conditions associated with the disease
- average afe of confirmed diagnosis of ECD is 20 years ( considered to be a disease mostly middle aged geriatric horses)
what happens when hypothalamic control of dopamine is disrupted
- dopamine normally inhibits hormone production and release from the pituitary pars intermedia and absense of controls results in excessive production and release of pituitary pars intermedia hormones
- pituitary pars intermedia produces and releases pro-opiomelanocortin (POMC)
- POMC - is converted into ACTH by PC1
- stimulates cortisol release from the adrenal cortex
- hypertrophy, hyperplasia, and adenoma formation within pituitary pars intermedia disfunction
- enlarge causes compresses pituitary lobes and interfear with function
what are the metabolic effects of cortisol
- elivated effects of cortisol = increased cortisol and clearance
- stress response
- blood pressure and heart function
- muscle tone
- immune reponse to infection
- inflammation
- nerve function
- connective tissue repair
- balance insuling effects
- regulation of carbs, fat and protein metabolism
clinical signs of cushings disease
- hypertricosis
- hyperhydrosis
- chronic reoccuring laminitis
- epaxial muscle wastage
- polydipsia and polyuria
- infertility
- weight loss
- pot belly
- immunosuppresion
- delayed wound healing
- abnormal mammary gland development
- lethargy and poor athletic performance
management of cushings disease
- nutrition - low WSC (functions)
- dental and hoof care
- thermoregulatory assistance
pharmacologic treatment of cushings
- dopamine receptor agonist - perolide
what is EMS
- equine metabolic syndrome
- occurs in animals with excessive adipose tissue (not all)
- metabolically and hormonally active abdominal, hepatic and muscle adipose tissue trigger a cascade events that lead to insulin dysregulation and persistent hyperglycemia
- characterized as a collection of risk factors that predispose the horse to endocrinopathic laminitis
- insulin dysregulation manifests as basal hyperinsulemia and elevated prolonged hyperglycemia
what is the development pathway for metabolic syndrome
it has not been clearly elucidated
- number of proposed mechanisms linking obesity, insulin resistance and other features of metabolic syndrome exist
- EMS may develop through more than one pathway
- suspected genetic component
- susceptible horses in the triggering environment develp EMS
what is the diagnosis of EMS
- obesity = abnormal fat distribution (eye fat pads, neck, shoulder, loin and tailhead)
- age of onset (8-18 years )
- specific breeds
- high body condition score, founder rings and reginal adoposity
- high neck crest score
- low adiponectin
- high c petide
management of EMS
- exercise
- 40% NSC DIET
treatment of EMS
- levothyroxine (not long term) - induce weight loss, increase insulin insensitivity
- metformin hydrochloride - decreases hyperglycemia and increases insulin sensitivity
prevention is key
what is EAS
- equine asthma syndrome, respiratory conditions ranging from mild (inflammatory airway disease) to severe (recurrent airway obstruction)
what is IAD
- inflammatory airway disease
- condition usually observed in young to middle aged horses that present with coughing and poor performance
-condition persists for a minimum of 4 weeks and resolves either spontaneously or with treatment - recurrence is uncommon
- some horses are at risk for ROA but not always
- do not present with increased respiratory effort at rest and airflow limitation is minimal
- hyperresponsiveness ( heightened sensitivity to particular matter
- race horses in training suffer a form of IAD characterized by coughing, mucous in the trachea and high bacterial counts in the trachea
what is ROA
- recurrent airway obstruction
- chronic, non infectious, inflammatory lower airway disease
- occurs mostly in hay fed, stabled horses that are exposed to dusts or organic matter (aerosols) particularily molds and actinomycetes (Aspergillus)
what is stage 1 of ROA
- chronic coughing
what is stage 2 of ROA
- audible breathing sounds
- exercise intollerance
- tracheolbrochial secretions increase
- neutrophils may increase