Metabolic and Endocrine Pathology Flashcards
What is hypopituitarism?
A conditions that occurs due to decreased production of one of the pituitary hormones, this is a rare disorders and the symptoms are dependent on age
-disorders include dwarfism, delayed growth, sexual and reproductive issues, and diabetes insipidus
What is hyperpituatarism?
a condition where one or more of the pituitary hormones is overproduced, symptoms depend on which hormone is secreted too much and age of onset
-disorders include gigantism, hirsutism, galactorrhea (abnormal lactation in males or females), amenorrhea, infertility, and impotence
What is Addison’s Disease?
What are the common signs and symptoms with this condition?
a form of adrenal dysfunction that presents with hypofunction of the adrenal cortex with subsequent decreased production of both cortisol and aldosterone
SxS include widespread metabolic dysfunction, hypotension, weakness, anorexia, weight loss, altered pigmentation, and, if left untreated, shock and death
What is Cushing’s Syndrome?
What are the common signs and symptoms with this condition?
a form of adrenal dysfunction characterized by hyperfunction of the adrenal gland allowing for excessive amounts of cortisol production
SxS evolve over years and can included persistent hyperglycemia, growth failure, truncal obesity, purple abdominal striae, “moon shaped face”, “buffalo hump” at the base of the cervical spine, weakness, acne, HTN, and male gynecomastia as well as depression, memory loss, and poor concentration
What is hypothyroidism?
a condition caused by decreased levels of thyroid hormones in the bloodstream which slows metabolic processes
-symptoms can include weakness, fatigue, decreased HR, weight gain, delayed puberty, and retarded growth and development
What is hyperthyroidism?
a condition that arises due to excessive levels of thyroid hormones in the bloodstream
-symptoms can include increased nervousness, excessive sweating, weight loss, increased BP, myopathy, and an enlarged thyroid gland
What is Grave’s Disease?
What are the common signs and symptoms with this condition?
the most specific cause of hyperthyroidism and is most common in women over 20yo but can occur in men as well and effect any age group
SxS include those of hyperthyroidism such as the presence of an enlarged thyroid gland (goiter) heat intolerance, nervousness, weight loss, tremor, and palpitations
What is hypoparathyroidism?
a condition which occurs due to low levels of parathyroid hormone production
- symptoms may include hypocalcemia, neurological symptoms such as seizures, cognitive defects, short stature, tetany, muscle pain, and cramps
- treatment includes intravenous calcium injection
What is hyperparathyroidism?
a condition that occurs due to excessive levels of parathyroid hormone production that leads to disruption of calcium, phosphate, and bone metabolism
-SxS include renal stones and kidney damage, depression, memory loss, muscle wasting, bone deformity, and myopathy
What is Type 1 Diabetes Mellitus?
What are the common signs and symptoms with this condition?
occurs when the pancreas fails to produce enough or any insulin and is normally diagnosed in childhood but can occur at any age and is also known as insulin dependent or juvenile diabetes
SxS include rapid onset of symptoms such as weight loss, ketoacidosis, polyuria, polydipsia, blurred vision, dehydration, and fatigue
What is Type 2 Diabetes Mellitus?
What are the common signs and symptoms with this condition?
typically occurs in the population over the age of 45 but there has been an increase in childhood cases, this form of diabetes is when the body becomes insensitive of the insulin it produces and it no longer has an effect
SxS are similar to type 1 DM (fatigue, weight loss, polyuria, blurred vision, etc.) but ketoacidosis is more rare due to the body still producing insulin
What is the difference between primary and secondary male hypogonadism?
Primary hypogonadism is when there is a deficiency in testosterone secondary to failure of the testes to respond to FSH and LH
Secondary hypogonadism is when there is a failure of the hypothalamus or pituitary gland to produce hormones that will subsequently stimulate the production of testosterone
What are the symptoms of male hypogonadism before and after puberty?
Before: sparse body hair, underdevelopment of skeletal muscle, long arms and legs secondary to a delay in the closure of epiphyseal growth plates
After: decreased libido, erectile dysfunction, infertility, decreased mood and cognitive skills, and sleep issues
What is the most common cause of primary male hypogonadism?
Klinefelter’s Syndrome
What is the difference between primary and secondary hypogonadism in females?
Primary: failure of gonads to produce amount of sex steroid sufficient to suppress secretion of LH and FSH at normal levels
Secondary: failure of hypothalamus or pituitary to produces hormones that stimulate production of estrogen