Metabolic

Question 1

What are some complications of leptin gene mutations?

Answer 1

lethal childhood infection
obesity
diabetes
hypothalamic hypogonadism

Question 2

what is the portal visceral hypothesis?

Answer 2

inc central adiposity leads to inc fatty acid delivery to the liver
-directly blocks insulin action

Question 3

what does the adipose tissue secrete

Answer 3

leptin, IL6, angio II

Question 4

whats pickwickian syndrome?

Answer 4

irregular breathing, cyanosis, secondary polycythemia, right ventric dysfunction and pulm htn

Question 5

what hypersensitivity reaction occurs in the islets of type I diabetics?

Answer 5

type IV - cell mediated

Question 6

which type of diabetes is amyloid present in?

Answer 6

type II

Question 7

What HLA are type one diabetics associated with?

Answer 7

HLA DR 3, HLA DR4

Question 8

What causes claudication in diabetics?

Answer 8

atherosclerosis

Question 9

what pathological procesess cause renal deficiency in diabetics?

Answer 9

hyaline arteriosclerosis and capillary BM thickening

Question 10

which cells are particularly affected by sorbitol?

Answer 10

schwann cells, pericytes, lens

Question 11

What hormones are inhibited with a somatostatinoma and what results because of this?

Answer 11

inhib of gastrin –> achlorhydria

inhib of CCK –> cholelithiasis, steatorrhea