endocrine-adrenal medulla Flashcards
1
Q
what makes up the adrenal medulla
A
neural crest derived chromaffin cells
2
Q
what tumor
“tumor chromaffin cells. increased serum catecholamines”
A
pheochromocytoma
3
Q
what are some signs & symptoms seen with pheochromocytomas
A
episodic HTN, headache, palpitations, tachycardia, sweating
4
Q
how do you diagnose a pheochromocytoma
A
serum metanephrines and increased 24 hour urine metanephrines and vanillymandelic acid
5
Q
why do you administer phenoxybenzamine (irreversible a-blocker) administered perioperatively to surgical excision of a pheochromocytoma?
A
because catecholamines can leak into the blood stream during tumor manipulation and cause a hypertensive crisis
6
Q
what syndromes are associated with pheochromocytomas? (4)
A
MEN 2A
MEN 2B
von hippel-lindau disease
NF type 1
