Endocrine- anterior pituitary Flashcards
Name some functional pituitary adenomas, which is the most common?
- prolactinoma - most common
- growth hormone adenoma
- ACTH adenoma
- TSH/ LH/ FSH - very rare
What are the symptoms of a prolactinoma?
females - galactorrhea, amenorrhea, infertility
males - dec libido, impotenence
What is the treatment for prolactinoma?
dopamine agonists or surgery
If a growth hormone adenoma is present in a child, what disease would it cause? adults?
child -gigantism
adults - acromegaly
Why can a growth hormone adenoma cause secondary diabetes?
GH dec glucose uptake into cells
-inc insulin resistance
In a person with a growth hormone adenoma, what related hormone is elevated besides GH?
IGF1
ACTH producing adenomas cause what syndrome?
cushings
which type of pituitary adenoma is PAS+?
ACTH producing
Why is a TSH producing adenoma unique?
only thing that could cause elevated TSH
What are some general symptoms of a pituitarial mass?
bitemporal hemianopsia - impingment of chiasm
hypopituitarism
headache
What are the three usual tumors of MEN1 syndrome?
- pituitary adenoma
- Parathyroid hyperplasia
- pancreatic islet adenoma
What is a carney complex? what are the symptoms caused by?
myxomas, pigmentation, endocrine overreactivity
-due to mutation in PRKAR1A
What is the most common cause of hypopituitarism in adults? children?
adults - pituitary adenoma
children - craniopharyngioma
What is sheehan syndrome?
infarction of pituitary gland during pregnancy
-demand of pituitary gland is high but its’ size does not inc
-amenorrhea, hypothyroidism, poor lactation, loss of pubic hair
What is laron syndrome?
auto recessive mutation of GH receptor
-patients are obese with high serum GH and low IGF1
