Mechanism of Actions Flashcards
macrocyclic lactones
glutamate chloride channel agonists
Ca2+ influx
paralysis
organophosphate
inhibits cholinesterase irreversibly
carbamates
inhibits cholinesterase reversibly
pyrethroids
opens Na+ channels
constant depolarisation
knock down effect
amitraz
mao inhibitor
fipronil
GABA antagonst
Pyripole
GABA antagonist
Indoxacarb
Na channel blocker
imidacloprid
dinotefuran
nicotinic Ach agonist
isoxazolines
GABA antagonist
Glutamate gated Cl- channel antagonist
benzimidazoles
inhibtion of tubulin polymerasation
and cellular transport
and energy metabolis
levamisole
Nicotinic Ach agonist
Pyrantel
Nicotinic Ach Agonist
Terbinafin
inhibits squalene –> ergosterol
Azoles
Inhibit Lanosterol –> ergosterol
Griseofuluin
inhibit microtubule formation
Nystatin
membrane disruption
bind to ergosterol binding site
changing complex and permeability
ionophores
form lipophilic complexes with alkali cations Na influx proton exchange acidosis mitochondrial inhibiton cell death
triazines
inhibit nuclear division of schizonts
antihistamines
inverse agonists
favour the inactive state to bring balance
antimetabolites
irreversibly block enzymes
inhibit or cause dna damage