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Pharma > Mechanism of Actions > Flashcards

Mechanism of Actions Flashcards

1
Q

macrocyclic lactones

A

glutamate chloride channel agonists
Ca2+ influx
paralysis

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2
Q

organophosphate

A

inhibits cholinesterase irreversibly

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3
Q

carbamates

A

inhibits cholinesterase reversibly

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4
Q

pyrethroids

A

opens Na+ channels
constant depolarisation
knock down effect

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5
Q

amitraz

A

mao inhibitor

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6
Q

fipronil

A

GABA antagonst

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7
Q

Pyripole

A

GABA antagonist

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8
Q

Indoxacarb

A

Na channel blocker

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9
Q

imidacloprid

dinotefuran

A

nicotinic Ach agonist

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10
Q

isoxazolines

A

GABA antagonist

Glutamate gated Cl- channel antagonist

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11
Q

benzimidazoles

A

inhibtion of tubulin polymerasation
and cellular transport
and energy metabolis

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12
Q

levamisole

A

Nicotinic Ach agonist

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13
Q

Pyrantel

A

Nicotinic Ach Agonist

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14
Q

Terbinafin

A

inhibits squalene –> ergosterol

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15
Q

Azoles

A

Inhibit Lanosterol –> ergosterol

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16
Q

Griseofuluin

A

inhibit microtubule formation

17
Q

Nystatin

A

membrane disruption
bind to ergosterol binding site
changing complex and permeability

18
Q

ionophores

A 
form lipophilic complexes with alkali cations
Na influx
proton exchange
acidosis
mitochondrial inhibiton
cell death
19
Q

triazines

A

inhibit nuclear division of schizonts

20
Q

antihistamines

A

inverse agonists

favour the inactive state to bring balance

21
Q

antimetabolites

A

irreversibly block enzymes

inhibit or cause dna damage

Pharma (33 decks)

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