B2

Question 1

ligand definition

Answer 1

anything that binds to a receptor to form a complex

Question 2

docking

Answer 2

how receptors bind to ligands

Question 3

affinity

Answer 3

how much a drug likes a receptor

Question 4

association

Answer 4

process that binds ligand and receptor together

Question 5

dissociation

Answer 5

process that releases the ligand and the receptor from eachother

Question 6

dissociation constant

Answer 6

reaction speed of dissociation - reaction speed of association

Question 7

continuous dose curves

Answer 7

either linear or semilogarithmic

as you increase the dose, more receptors become occupied

Question 8

ec-50

Answer 8

dose required to reach 50% of drug efficacy

Question 9

potency

Answer 9

a measure of the activity of the drug
fentanyl is more potent that morphine
morphine is more potent than meperidine

Question 10

efficacy

Answer 10

shows the depth of effect

Question 11

quantal dose response curves

Answer 11

ED50
TD50
LD50

Question 12

ED 50

Answer 12

effective dose 50

dose that acheives an effect in 50% of the population

Question 13

td 50

Answer 13

dose that shows side effects in 50% of the population

Question 14

LD50

Answer 14

when 50% of the population die due to overdose

Question 15

Ti

Answer 15

ratio between the LD50 and ED 50

Question 16

therapeutic window

Answer 16

gap on graph between ED50 and TD50

Question 17

full agonist

Answer 17

binds to receptor with a high affinity and produced maximum response

Question 18

full antagonist

Answer 18

has a high affinity to the receptor and doesnt produce any effect

Question 19

partial agonist

Answer 19

binds to receptor and produces a lower than maximum response

Question 20

inverse agonists

Answer 20

receptor balanced between 2 states

Question 21

2 types of antagonists

Answer 21

non-receptor antagonists

receptor antagonists

Question 22

non receptor antagonists

Answer 22

physiological

chemical

Question 23

physiological antagonists

Answer 23

when 2 drugs have opposite physiological actions but on different receptors

Question 24

chemical antagonists

Answer 24

bind together with a high affinity

Question 25

receptor antagonist

Answer 25

active site binding. orthosteric