B2 Flashcards
ligand definition
anything that binds to a receptor to form a complex
docking
how receptors bind to ligands
affinity
how much a drug likes a receptor
association
process that binds ligand and receptor together
dissociation
process that releases the ligand and the receptor from eachother
dissociation constant
reaction speed of dissociation - reaction speed of association
continuous dose curves
either linear or semilogarithmic
as you increase the dose, more receptors become occupied
ec-50
dose required to reach 50% of drug efficacy
potency
a measure of the activity of the drug
fentanyl is more potent that morphine
morphine is more potent than meperidine
efficacy
shows the depth of effect
quantal dose response curves
ED50
TD50
LD50
ED 50
effective dose 50
dose that acheives an effect in 50% of the population
td 50
dose that shows side effects in 50% of the population
LD50
when 50% of the population die due to overdose
Ti
ratio between the LD50 and ED 50
therapeutic window
gap on graph between ED50 and TD50
full agonist
binds to receptor with a high affinity and produced maximum response
full antagonist
has a high affinity to the receptor and doesnt produce any effect
partial agonist
binds to receptor and produces a lower than maximum response
inverse agonists
receptor balanced between 2 states
2 types of antagonists
non-receptor antagonists
receptor antagonists
non receptor antagonists
physiological
chemical
physiological antagonists
when 2 drugs have opposite physiological actions but on different receptors
chemical antagonists
bind together with a high affinity
receptor antagonist
active site binding. orthosteric
