B24 Flashcards
etiotropic agents
cancer chemo
antimicrobial
antiviral
antiparasitic
selective toxicity
only targets infectious agents
unique targets
only target unique bacteria
similar targets
target infectious agents with a higher affinity
common target
target is similar or the same in the host
most toxic
mechanisms of unique targets
inhibition of cell wall synthesis
folic acid synthesis
mechanism of similar targets
dihydrofolate reductase inhibition
protein synthesis inhibitors
common targets
antineoplastics
levamisole
organophosphate
describing efficacy
MIC
MPC
MBC
MSW
mic
minimum inhibitory conc
determines if bacteria is resistant or not
MPC
mutant prevention window
the conc to prevent mutants and resistance
MBC
min bactericidal conc
whats best
to reach MBC
mutant selective window
best to give drug over MPC as it kills all bacteria
post antibiotic effect
after drug declines below the mic, there is a delayed antibacterial effect.
synergy
benefit
e.g. sulphonamides and DAP
additive
broaden spectrum
e.g. gentamycin and metronidazole
aerobic + anaerobic
antagonistic
erythromycin and chloramphenicol both 50S
resistance
chromosomal
plasmid encoded resistance - transduction, transformation, conjugation
types of resistance mechanism
efflux pumps AB degrading enzymes AB altering enzymes increase integrity of cell wall modify binding sites
