B24

Question 1

etiotropic agents

Answer 1

cancer chemo
antimicrobial
antiviral
antiparasitic

Question 2

selective toxicity

Answer 2

only targets infectious agents

Question 3

unique targets

Answer 3

only target unique bacteria

Question 4

similar targets

Answer 4

target infectious agents with a higher affinity

Question 5

common target

Answer 5

target is similar or the same in the host

most toxic

Question 6

mechanisms of unique targets

Answer 6

inhibition of cell wall synthesis

folic acid synthesis

Question 7

mechanism of similar targets

Answer 7

dihydrofolate reductase inhibition

protein synthesis inhibitors

Question 8

common targets

Answer 8

antineoplastics
levamisole
organophosphate

Question 9

describing efficacy

Answer 9

MIC
MPC
MBC
MSW

Question 10

mic

Answer 10

minimum inhibitory conc

determines if bacteria is resistant or not

Question 11

MPC

Answer 11

mutant prevention window

the conc to prevent mutants and resistance

Question 12

MBC

Answer 12

min bactericidal conc

Question 13

whats best

Answer 13

to reach MBC

Question 14

mutant selective window

Answer 14

best to give drug over MPC as it kills all bacteria

Question 15

post antibiotic effect

Answer 15

after drug declines below the mic, there is a delayed antibacterial effect.

Question 16

synergy

Answer 16

benefit

e.g. sulphonamides and DAP

Question 17

additive

Answer 17

broaden spectrum
e.g. gentamycin and metronidazole
aerobic + anaerobic

Question 18

antagonistic

Answer 18

erythromycin and chloramphenicol both 50S

Question 19

resistance

Answer 19

chromosomal

plasmid encoded resistance - transduction, transformation, conjugation

Question 20

types of resistance mechanism

Answer 20

efflux pumps
AB degrading enzymes
AB altering enzymes
increase integrity of cell wall
modify binding sites