B8

Question 1

principles of pharmacotherapeutics

Answer 1

repeat admin
steadt state
bioavailabiltiy
loading dose
maintanence dose

Question 2

maintanence dose

Answer 2

dose of drug needed to maintain a desired steady state level in plasma

the desired drug in plasma x clearance

Question 3

loading dose

Answer 3

desired drug in plasma X Vd

when therapeutic conc of a drug in plasma must be acheived rapidly

Question 4

steady state

Answer 4

the average between the high point after administration and the low point before the next administration

Question 5

repeat admin

Answer 5

if a drug thats eliminated by first order kinetics, is readministered repeatedly, the average plasma conc of the drug will increase until a mean steady state is reached

Question 6

zero order elimination

Answer 6

a constant amount of drug will be eliminated per time unit following administration

therapeutic dose exceed the capacity of the elimination mechanism

Question 7

first order elimination

Answer 7

elimination of most drugs
elimination of a constant fraction of drug per time unit

when elimination systems are not saturated by the drug

Question 8

one compartment open model

Answer 8

body is seen as one continuous fluid phase into which drug is administered and diffuses through

Question 9

rate of constant elimination

Answer 9

Cl = K x Vd

Question 10

half life

Answer 10

time it takes for plasma drug conc to be reduced by 50%

Question 11

2 compartment model

Answer 11

does not have a constant relationship
initially = rapid changes in plasma conc (distribution)
then a more linear decrease (elimination)

Question 12

first to reach equilibrium

Answer 12

heart, lung, kidney, liver, blood

Question 13

last to reach equilibrium

Answer 13

skin, fat, bone

Question 14

non compartmental

Answer 14

no direct relationship to physiological space

dependant on estimation of total drug exposure