B14 Flashcards
1
Q
mechanism of action of LAs
A
block action potential generation
block Na channels
2
Q
order of penetration of LAs
A
Axons –> non myelinated axons –> small myelinated axons –> large myelinated axons
3
Q
order of sensation loss
A
Pain –> warmth –> touch –> deep pressure –> motor function
4
Q
effect of LAs on refractory ion channels
A
small affinity
inhibit opening of Na channels
5
Q
effect of LAs on closed ion channels
A
large affinity
inhibit reopening
6
Q
effect of LAs on open ion channels
A
large affinity
close Na channels
7
Q
effect of LAs on inactevated ion channels
A
large affinity
prolong inactive period
8
Q
esters
A
procain
oxybuprocaine
tetracaine
9
Q
amides
A
lidocaine
bupivacaine
ropivacaine
10
Q
toxicity of LAs
A
Mepi pro lido tetra bupi
11
Q
Ideal LAs
A
stable H2O soluble quick onset long duration non toxic non allergy
12
Q
application of LAs
A
topical local perineural intra auricular IV regional epidural
