B3 AND 4 Flashcards
safe Ti
> 10
unsafe ti
<10
Pi
protective index
range between LD 50 and TD 50
MOS
margin of safety
between LD 1 and ED 99
standard safety margin
((LD 1 - ED 99 ) / ED 99 ) x 100
on target
drugs bind to appropriate receptor in inappropriate conditions
off target
drug binds to unintended target/ receptor
production of toxic metabolites
lipid peroxidation
ROS
depletion of glutathione
modification of sulfhydryl groups
production of harmful immune response
hypersenitivity rxn
autoimmunity
idiosyncratic response
rare side effects for no obvious reason
causes of toxicity
genetic predisposition
non selectve action
innapropriate use
factors influencing toxicity
age genetics pre existing conditions other drugs dose and routes extracorporeal intracorporeal synergy addition potentiation antagonism
factors influencing drug action
age gender health condition dosage route feeding tolerance dependance idiosyncrasy allergy
drug interactions result in
loss of potency
increase in toxicity
other adverse effects
loss of potency due to
competitive antagonists - no effect on max effect
