Mech Of Action Flashcards
DPP 4 inhibitors
Saxigliptine, Sitagliptin, Linagliptine
Prucalopride
5 HT4 receptor agonist = prokinetic
Treatment of idiopathic chronic constipation in females
Nystatin mechanism
Bind to ergosterol cause pores
Inhibit glucan synthetase that forms B glucans.
Echinochandins
Caspofungin
Anidulafungin
Micafungin
5 flucytosine
Is converted to 5 florouracil - Pyrimidine analog- inhibit DNA synthesis
Calcinuerin inhibitors ( protein phosphate that activate T cell)
Cyclosporine
Tacrolimus
Alpha 1A receptor antagonist
Alfuzosin
Silodosin
Tamsulosin
5HT 1b/1d receptor Agonist
Sumatriptan
Rizatriptan
Zolmitriptan
Naratriptan
Direct Thrombin (IIa) Inhibitor
Dabigatran. Oral
GLP1 analogues
Liraglutide- once daily inj
Exenatide-twice daily
SGLT2 inhibitors
Canagliflozin
Dapagliflozin
Cholestrylamine mechanism of action
Anion exchange resin bind with enzyme in intestine and inhibit cholesterol synthesis.
Decrease LDL, increase HDL
Increase TG. العبيط
What is secreted by the adrenal gland.
Adrenal Cortex
Glomerulosa-Aldosterone
Fasciculata-Cortisol
Reticularis - Androgens
Adrenal Medulla - Epinephrine/ Norepinephrine
Progesterone Antagonist
Mifepristone
Weak androgen for treatment of endometriosis
Danazol
Synthetic progestin with potent antiandrogenic property
Cyproterone acetate
Used for hairsutism
Acne
Virulizing Syndrome
Precocious puberty in boys
Leflunamide
Inhibit Dihydro Orate Dehydrogenase needed for Pyrimidine synthesis
For treatment of Rheumatoid Arthritis
Triggers for release of ADH?
Hyperosmolarity
High Na level
Dehydration
Function of ADH
Decrease Urine
Decrease sweating
Increase Blood Pressure
What is Pinaverium Bromide?
GIT calcium antagonist , antispasmodic in IBS
What is the mechanism of action of Trazodone and Nafazadone
Seratonin reputable inhibitors
Block 5HT2a
Block H1-Sedation
Block a1 -orthostasis
Trazodone -priapism
Nafazadone- hepatotoxic
