Drug Drug interactions

Question 1

Atomoxetine + CYP 2D6 inhibitors ( paroxetine, fluoxetine, quinidine)

Answer 1

Increase plasma conc of atomoxetine

Question 2

atomoxetine +salbutamol

Answer 2

increase heart rate

Question 3

Clarithromycin + warfarin

Answer 3

Clarithromycin inhibit CYP3A4..Increase warfarin concentration

Question 4

Indinavir + St John worts

Answer 4

Decrease indinavir level

St John warts are enzyme inducers

Question 5

Serotonin re uptake inhibitor + indinavir

Answer 5

Seratonin syndrome

Question 6

Amiodarone + Grape fruit

Answer 6

Stop grapefruit

Grape fruit is enzyme inhibitor ….increase Amiodarone conc. Toxicity

Question 7

Amiodarone is Enzyme …………

Answer 7

inhibitor

Question 8

Digoxin + metoclopramide

Answer 8

Decrease digoxin absorption

Question 9

Drug that reduce the INR with warfarin

Answer 9

Carbamazepine 
Phenytoin 
Rifampicin
Oral contraceptives 
Griseofulvin

Question 10

Drug interactions with NSAIDs

Answer 10

Lithium

ACE inhibitors, ARBs

Question 11

Interaction of colchicine and fibrates/statins

Answer 11

Rehabdomyosis

Monitor creating kinase

Question 12

Sulphonamide + warfarin

Answer 12

Sulphonamide displace the binding of warfarin to plasma-protein (albumin)…increase bleeding

Question 13

Amiodarone interactions?

Answer 13

Amiodarone is enzyme Inhibitor so increase the concentration of warfarin, digoxin, statins

Question 14

Repaglinide + Gemifibrozil

Answer 14

Increase Repaglinide concentrations

Question 15

Cephalosporins/ Ciprofloxacin/Sulphonamide with warfarin

Answer 15

Increase INR and bleeding

Question 16

Penicillin and oral contraceptives

Answer 16

Dec the effect of oral contraceptives

Question 17

Aminoglycoside with Loop diuretic, cephalosporins

Answer 17

Nephrotoxic

Question 18

Sulphonamide and sulphonyl urea

Answer 18

Hypoglycemia

Kidney stones

Question 19

Penicillins and methotrexate

Answer 19

Increase methotrexate level