Malignant Bone Tumours Flashcards

1
Q

what is the most common malignant primary bone tumour

A

multiple myeloma

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2
Q

clinical presentation of primary bone cancer

A

persistent increasing pain - worse at night, not associated with movement
swelling/erythema over joint
palpable mass
pathological fracture

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3
Q

what is multiple myeloma

A

malignant disease of the plasma cells of the bone marrow

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4
Q

who does myeloma generally affect

A

older patients

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5
Q

clinical presentation of multiple myeloma

A

hypercalcaemia, anaemia, renal impairment and bone pain

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6
Q

what is osteosarcoma

A

malignant tumour which produces bone

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7
Q

usual spread of osteosarcoma

A

haematogenous

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8
Q

when do most cases of osteosarcoma present

A

adolescence and early adulthood

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9
Q

what is associated with elderly presentations of osteosarcoma

A

pagets

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10
Q

where do most osteosarcomas occur

A

around the knee: distal femur, proximal tibia

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11
Q

management of osteosarcoma

A

chemo + limb salvage

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12
Q

what is a chondrosarcoma

A

cartilage producing primary bone tumour

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13
Q

who tends to present with chondrosarcoma

A

40-75

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14
Q

where do chondrosarcomas tend to be found

A

pelvis or proximal femur

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15
Q

where do fibrosarcoma’s tend to occur

A

in abnormal bone

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16
Q

what is ewing’s sarcoma

A

primary bone tumour of the endothelial cells of the bone marrow

17
Q

what characterises ewings sarcoma

A

loss of bone

18
Q

most common age for ewings sarcoma to present

A

10-20

19
Q

clinical presentation of ewings

A

Hot, swollen, tender joint or limb with raised inflammatory markers

20
Q

where is ewings usually found

A

diaphysis of long bones: distal femur, proximal tibia

21
Q

karyotypic abnormality seen in ewings

A

t(11;22)

22
Q

management of ewings

A

chemo with limb salvage +/- adjuvant radiation

23
Q

name 5 cancers which commonly met to bones

A

breast
prostate
lung
renal cell carcinoma
thyroid

24
Q

name some bones associated with mets

A

vertebra, pelvis, skull, ribs, femur