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Year 3 Haematology > Lymphoproliferative disorders > Flashcards

Lymphoproliferative disorders Flashcards

1
Q

How can lymphoma present?

A

lymphadenopathy or
extranodal disease or
bone marrow involvement

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2
Q

Systemic B symptoms

A 
weight loss >10% in 6 months 
fever 
drenching night sweats 
pruritis 
fatigue
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3
Q

How to tell what type of lymphoma it is

A

biopsy - LN

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4
Q

How to tell where the lymphoma is

A

CT and clinical exam

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5
Q

Classification of “lymphoma”

A

Hodgkin

non Hodgkin - high grade and low grade

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6
Q

Lymphoproliferative disorders

A

ALL
CLL
Hodgkin lymphoma
non Hodgkin lymphoma

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7
Q

high grade NHL common type

A

diffuse large B cell lymphoma

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8
Q

low grade NHL common type

A

follicular

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9
Q

ALL - blood signs

A

high WCC, low Hb and low platelets

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10
Q

diagnosing ALL

A

> 20% lymphoblasts in the bone marrow

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11
Q

ALL - age

A

75% under 6 years

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12
Q

Are most ALL B or T cell lineages?

A

B

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13
Q

ALL - history of symptoms

A

bone marrow failure

bone/joint pain

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14
Q

Standard treatment for ALL

A

induction chemo
consolidation therapy
CNS directed treatment - intrathecal
maintenance treatment for 18 months

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15
Q

Who would receive a stem cell transplant for ALL?

A

high risk

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16
Q

newer therapies for ALL

A

bispecific T cell engagers - BiTe

CAR

17
Q

problems with newer therapies for ALL

A

cytokine release syndrome

neurotoxicity

18
Q

ALL poor risk factors

A 
increasing age 
increasing WCC
immunophenotyped
cytogenetics - Philadelphia gene
slow/poor response to treatment
19
Q

CLL diagnosis

A

blood >5x10 9 lymphocytes, bone marrow >30% lymphocytes

20
Q

Presentation of CLL

A

often asymptomatic
frequent findings = splenomegaly, bone marrow failure, lymphadenopathy, fever, sweats
less common = hepatomegaly, infections, weight loss

21
Q

Associated findings with CLL

A

immunoparesis

haemolytic anaemia

22
Q

Staging for CLL

A

binets

23
Q

Indication for treatment - CLL

A

massive lymphadenopathy
progressive splenomegaly
progressive bone marrow failure
systemic symptoms

24
Q

CLL treatment

A

often nothing
cytotoxic chemo
monoclonal ab
novel agent eg tyrosine kinase inhibitor

25
Q

CLL poor prognostic factors

A

advanced disease - Binet’s
atypical lymphocyte morphology
loss/mutation p53
rapid lymphocyte doubling time

26
Q

Staging lymphoma

A

LN biopsy
CT
bone marrow aspirate and trephine

27
Q

High grade NHL

A

aggressive and fast growing
combo chemo required
can be cured

28
Q

low grade NHL

A

indolent, often asymptomatic
responds to chemo
incurable

29
Q

combo chemo for NHL

A

Anti CD20 mab and chemo

30
Q

Epidemiology of HL

A

30% of all lymphomas
bimodal age curve
EBV
males

31
Q

HL treatment

A

combo chemo (ABVD) +/- radiotherapy
monoclonal ab (anti-CD30)
immunotherapy
PET scan to monitor response

Year 3 Haematology (18 decks)

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