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Year 3 Haematology > Autoimmunity > Flashcards

Autoimmunity Flashcards

1
Q

What does an infected cell do in the innate immune system?

A

downregulate MHC1
secrete INFa/b
activate NK cell to secrete INFg

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2
Q

Sentinel cells and examples

A

innate immune system - embeded in tissues

eg Langerhans, Kupffer, dendritic cells, alveolar macropahges etc

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3
Q

2 main functions of complement

A

opsonisation

MAC

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4
Q

Tolerance

A

A state of unresponsiveness of the immune system to self

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5
Q

central tolerance

A

thymus

negative selection and inactivation of cells that recognise self

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6
Q

peripheral tolerance

A

inhibit immune response

T reg cells

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7
Q

How can T reg cells be turned off?

A

IL-17 from Th17

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8
Q

Autoimmunity

A

physiological autorecognition with secondary epiphenomena

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9
Q

Autoimmune disease

A

immune response contributing directly to tissue/organ damage

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10
Q

Autoimmune disease epidemiology

A

> 100 disorder
80% female
20% prevalence
HLA

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11
Q

What causes autoimmuity

A 
immune regulation 
hormonal 
genetic factors
environmental 
unknown
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12
Q

Cell mediated autoimmunity cells

A

T and NK cells

bypass B cells

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13
Q

cell mediated autoimmunity examples

A

Type 1 DM
crohns
psoriasis
coeliac

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14
Q

Familial gene - crohns

A

NOD2

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15
Q

What type of hypersensitivity reaction is antibody mediated autoimmunity?

A

2

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16
Q

example of antibody mediated autoimmunity

A

goodpastures

17
Q

briefly describe goodpastures

A

anti GBM - type 4 collagen
lungs - pulmonary haemorrhage
kidneys

18
Q

myaesthenia gravis association

A

thymoma

19
Q

What is myaesthnia gravis?

A

autoimmune disease against the NMJ

ACH receptor antibodies

20
Q

Molecular mimicry example and explain

A

rheumatic fever

antigen on bacteria share antigen on muscle cell

21
Q

organ specific vs non organ specific AI disease

A

specific - antigen to single organ/tissue eg thyroid, type 1 DM, myaesthnia gravis
non specific eg joints, skin
- SLE, RA, vasculitis

22
Q

Treating AI disease

A

immunosuppression
anti inflammatory
plasmapheresis
transplant

Year 3 Haematology (18 decks)

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