Haemostasis

Question 1

Things needed for clot formation

Answer 1

platelets
vW factor
coagulation factors

Question 2

How the clot is localised to a specific area

Answer 2

natural anticoagulants

Question 3

How does the clot vanish 1 week later?

Answer 3

fibrinolytic system

Question 4

How do platelets become activated?

Answer 4

subendothelial collagen exposed and stick to this

tissue factor released from tissues

Question 5

binding sites on platelets

Answer 5

Gp1a and 2a = collagen
Gp 1b = vW factor
Gp 2b and 3a = fibrinogen

Question 6

What induces platelet aggregation?

Answer 6

thromboxane from arachidonic acid (COX)

Question 7

vW factor binding sites

Answer 7

collagen, factor 8 and glycoprotein

Question 8

primary haemostatic plug

Answer 8

platelets, vW factor

Question 9

definitive clot

Answer 9

fibrin formation on top

Question 10

Coagulation factors

Answer 10

12,11,9,8,10, prothrombin, fibrinogen

Question 11

Haemophilia

Answer 11

A - factor 9 and B factor 8

coagulation cascade problem

Question 12

How does prothrombin –> fibrinogen occur?

Answer 12

prothrombin –> thrombin

fibrin –> fibrinogen

Question 13

3 natural anti coagulants

Answer 13

TFPI
AT
protein C+S

Question 14

Plasminogen activators

Answer 14

t-PA (alteplase)

u-PA

Question 15

Breakdown products of fibrin clot

Answer 15

D-dimer

Question 16

name antiplatelet medication

Answer 16

aspirin

clopidogrel, ticagrelor

Question 17

name anti-coagulant medications

Answer 17

warfarin
rivaroxaban
heparins

Question 18

Warfarin - what does it work on?

Answer 18

factor 10 and prothrombin