Immunotherapy Flashcards
What is acute rejection particularly associated with?
T cell response mediating immune cell infiltration
Some methods to inhibit T cell activation to prevent rejection
cyclosporine
anti-TCR = thymoglobulin
azathioprine and mycophenolate
Adaptive - active immunity
infection or exposure
vaccines
adaptive - passive immunity
placental IgG transfer
Ig therapy or immune cells
Memory with adaptive passive immunity?
no
Ig for post exposure prophylaxis
human normal Ig = hep A, rubella, measles, polio
specific = hep B, VZV, rabies
What is IVIg?
plasma derived IgG
replacement therapy for primary and secondary immunodeficiencies and autoimmune disorders
Monoclonal or polyclonal IgG with IVIg?
polyclonal
IVIg licensed indications
primary immunodeficiency
children with HIV
multiple myeloma
idiopathic thrombocytopenia purpura
direct immunotherapy
antibodies detect antigen on tumour cell and destroy it by recruiting immune system or by a toxin
Example of direct immunotherapy
Herceptin
monoclonal ab
CAR T cells
Indirect immunotherapy
immune system activated to render it able to seek and destroy tumour
Example of indirect immunotherapy
checkpoint inhibitor therapies
tumour vaccines
cytokine therapies
Cytokine therapies
PEGylated INF alpha
used in specific cancers eg melanoma and anti-viral
What type of monoclonal antibodies are most common?
human or humanised
