Lymphatic and Immune System Quiz Flashcards
Functions of Lymphatic System
Immunity
Lipid absorption
Fluid recovery
Organs Involved in Lymphatic System
Red bone marrow Thymus Tonsils Spleen Lymph nodes
Lymph
Clear, colorless fluid, similar to plasma but much less protein
Lymphatic Capillaries
Closed at one end
Tethered to surrounding tissue by protein filaments
Endothelial cells loosely overlapped
Lymphatic Vessels
Larger ones composed on tunica interna, tunica media, and tunica externa
Route of Lymph Flow
Lymphatic Capillaries
Collecting Vessels
Lymphatic Trunks
Collecting Ducts (Right Lymphatic and Thoracic)
Mechanisms of Lymph Flow
Low pressure and low speed
Aided by pumps
Moved along by rhythmic contractions of lymphatic vessels
Lymphatic Cells (Lymphocytes)
Natural Killer Cells
T Lymphocytes
B Lymphocytes
Antigen Presenting Cells
Lymphatic Tissue
Aggregations of lymphocytes in mucus membranes and CT of many organs
Lymph Nodes
Bean-shaped organs located around lymphatic vessels
Cortex and medulla
Flow is in one direction
Filter lymph
Palatine Tonsils
Pair at the posterior margin of the oral cavity
Lingual Tonsils
Pair at the root of the tongue
Pharyngeal Tonsil
Single tonsil on the wall of the pharynx (adenoid)
Thymus Gland
Two lobed organ in the mediastinum
Spleen
Red pulp filled with erythrocytes
While pulp filled with lymphocytes and macrophages
Blood reservoir and filters blood
2nd Line of Defense
Neutrophils, Eosinophils, Basophils, Macrophages
Neutrophils
Phagocytize bacteria
Create a killing zone
Kills itself
Eosinophils
Found in mucus membranes
Phagocytizes antigen-antibody complexes, allergens, and chemicals
Basophils
Secrete chemicals to attract leukocytes
Secrete histamine, leukotrienes, heparine
Macrophages
Displays foreign antigens
Secretes cytokines
Induces fever
Form outside of the circulatory system
Interferons
Produced by virally infected cells
Diffuse to neighboring cells to induce synthesis of antiviral proteins
Complement Proteins
Inactive proteins in blood plasma
When activated enhance immune, allergic, and inflammatory reactions
Antiviral Effect
Generalized protection
Activate natural killer cells and macrophages
Destroy infected host cells
Anticancer
Stimulate destruction of cancer cells
Pathways of Complement Activation
Classical pathway
Alternate pathway
Leptin pathway
Mechanisms of Action
Enhanced inflammation
Opsonization
Cytolysis
Phagocytosis
Classical Pathway
Begins with activation of C1
Specific response
Alternate Pathway
Begins with activation of C3
Leptin Pathway
Binds carbohydrates on the pathogen surface
C3A
Leads to inflammation
C3B
Leads to immune clearance
Phagocytosis
Cytolysis
Membrane Attack Complex
Complement proteins C5B to C9 form ring in plasma membrane of enemy cell causing cytolysis
Natural Killer Cells and Phagocytes
NK cells kill a variety of microbes and tumor cells
Phagocytes are neutrophils and macrophages
Phagocytosis
Chemotaxis
Adherence
Ingestion
Digestion and Killing
Chemotaxis
Attraction to chemicals from damaged tissues, complement proteins, or microbial products
Adherence
Attachment to plasma membrane of phagocyte
Ingestion
Engulf by pseudopods to form phagosome
Digestion and Killing
Merge with lysosome containing digestive enzymes and form lethal oxidants
Exocytosis residual body
Inflammation
Defensive response to tissue injury
Limits speed of pathogens, then destroys them
Removes debris and initiates tissue repair
Cardinal Signs of Inflammation
Redness (caused by increased blood flow)
Swelling (caused by increased capillary permeability and filtration)
Heat (caused by increased blood flow)
Pain (caused by inflammatory chemicals: bradykinin and prostaglandins)
Fever
Promotes interferon activity
Accelerates metabolic rate and tissue repair
Inhibits pathogen reproduction
Course of a Fever
- Infection and pyrogen secretion
- Hypothalamic thermostat is reset to higher set point
- Onset (body temperature rises)
- Stadium (body temperature oscillates around new set point)
- Infection ends, set point returns to normal
- Defervescence (body temperature returns to normal)
Mobilization of Defenses
Bradykinin, histamine, and leukotrienes are secreted by damaged cells, basophils, and mast cells